DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPK10 and ppk9

DIOPT Version :9

Sequence 1:	NP_001304998.1	Gene:	MAPK10 / 5602	HGNCID:	6872	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_593404.1	Gene:	ppk9 / 2541773	PomBaseID:	SPAC23H4.02	Length:	532	Species:	Schizosaccharomyces pombe

Alignment Length:	414	Identity:	99/414 - (23%)
Similarity:	163/414 - (39%)	Gaps:	116/414 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    89 NVAIKKLSRPFQ-NQTHA---------------KRAYRELVLMKCVNHKNIISLLNVF-TPQKTL 136
            |:|..||.:.|| |:..|               ||..||:.:::.::|.|||:|..|| .|:.|:
pombe    33 NLAKVKLGKHFQTNEKVALKMVYNDELEDKDTWKRLQREVTILRQLHHPNIITLYQVFRVPKYTV 97

Human   137 EEFQDVYLVMELMDANLCQVIQMELDHERMS-----YLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196
                   |.:|.||.:|..::   :.|.|:.     .:..|::..|.:.|...:.|||||..||:
pombe    98 -------LALEYMDTDLHSMV---VKHNRLDECTTRKIFRQIVHAIDYCHLHRVAHRDLKLENIL 152

Human   197 VKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE-NVDIWSVGCIM-----GE 255
            :..|..:|:.||||:........::....|.:|.|||||.|..|.. :||:|..|.::     ||
pombe   153 LNKDLVVKLTDFGLSNFMLDGSFLSTSCGTPHYAAPEVIQGRYYDGCDVDVWGCGILLYLMLVGE 217

Human   256 MVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGL-TFPKLFPDSLFP 319
                   ||..|.                        |:.|.:....|  |: |.|...
pombe   218 -------FPFEDV------------------------TISNVLSRVCK--GIYTIPSFV------ 243

Human   320 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYD---PAEVEAP---------- 371
                     :|.|.||:.:||::.|..||.|.:.:|||    |:.   |.....|
pombe   244 ---------SSSASDLIRQMLMVLPTSRIKVAEIMQHP----WFIADLPTHSRLPSRTSSFSSKH 295

Human   372 ------PPQ---IYDKQLDEREHTIEEWKE-LIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSES 426
                  ||.   ::|..:.....::.:..: ..:..:..|:..:.:|.....|.|:....:|.|.
pombe   296 RSVTFSPPDLAILFDPSITSPSSSVGQIPQPTDHSALSPSKPMSISGTESPNPDPASLCYSSYED 360

Human   427 LPPSSSVNDISSMSTDQTLASDTD 450
            |..::|.:  |.|:........||
pombe   361 LYSATSWH--SDMAESSGFLDPTD 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK10	NP_001304998.1	STKc_JNK	63..398	CDD:270840	87/360 (24%)
MAPK10	NP_001304998.1	S_TKc	64..359	CDD:214567	81/298 (27%)
ppk9	NP_593404.1	STKc_AMPK-like	22..273	CDD:270905	81/301 (27%)
		S_TKc	23..274	CDD:214567	81/302 (27%)
		AMPKA_C_like	426..531	CDD:302605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910