Protein Alignment MAPK9 and SLT2

DIOPT Version :10

• Sequence 1: NP_002743.3
• Gene: MAPK9 / 5601
• HGNCID: 6886
• Length: 424
• Species: Homo sapiens
• Sequence 2: NP_011895.1
• Gene: SLT2 / 856425
• SGDID: S000001072
• Length: 484
• Species: Saccharomyces cerevisiae
• Alignment Length: 457
• Identity: 160/457 - (35%)
• Similarity: 243/457 - (53%)
• Gaps: 72/457 - (15%)

Human    11 YSVQVADSTFTVLKRYQQLKPIGSGAQGIVC------AAFDTVLGINVAVKKLSRPFQNQTHAKR 69
            ::.:|.:..|:|.||:|.:|.||.||.||||      ||.||    .||:||::..|......||
Yeast     8 HTFKVFNQDFSVDKRFQLIKEIGHGAYGIVCSARFAEAAEDT----TVAIKKVTNVFSKTLLCKR 68

Human    70 AYRELVLLKCV-NHKNIISLLN---VFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERM 128
            :.|||.||:.. .||||..|.:   ||.|..::   ..:||..|||:.::.|:|.  ..|.....
Yeast    69 SLRELKLLRHFRGHKNITCLYDMDIVFYPDGSI---NGLYLYEELMECDMHQIIKSGQPLTDAHY 130

Human   129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVT 188
            ....||:|||:|::|||.::||||||.|::|.:||.|||.||||||....|     ..:|.||.|
Yeast   131 QSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVAT 195

Human   189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKL 252
            |:|||||::|. .||.:.:|:||.|||:.|.:.|..||:|.|:::|.|::::.||||..|.::::
Yeast   196 RWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRI 260

Human   253 -QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEAL 316
             ...|::|:......|.:.|..|:|:            ..|||.|||.:||..||.|||:|||||
Yeast   261 GSKNVQDYIHQLGFIPKVPFVNLYPN------------ANSQALDLLEQMLAFDPQKRITVDEAL 313

Human   317 RHPYITVWYDPAEAEAPPPQIYDAQLE---EREHAIEEWKELIYKEVMDW--------------- 363
            .|||:::|:|||:     ..:...:.|   |..:.:|:.|:::.:||.|:
Yeast   314 EHPYLSIWHDPAD-----EPVCSEKFEFSFESVNDMEDLKQMVIQEVQDFRLFVRQPLLEEQRQL 373

Human   364 ------EERSKNGVVKDQPSD-----AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417
                  :::.:....:.||||     ||.|....|.|.::.|.::.......:.|......||..
Yeast   374 QLQQQQQQQQQQQQQQQQPSDVDNGNAAASEENYPKQMATSNSVAPQQESFGIHSQNLPRHDADF 438

Human   418 GP 419
            .|
Yeast   439 PP 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK9	NP_002743.3	STKc_JNK	25..360	CDD:270840	139/356 (39%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..424		14/57 (25%)
SLT2	NP_011895.1	STKc_MPK1	22..355	CDD:173750	139/356 (39%)