Protein Alignment MAPK9 and nmo

DIOPT Version :10

• Sequence 1: NP_002743.3
• Gene: MAPK9 / 5601
• HGNCID: 6886
• Length: 424
• Species: Homo sapiens
• Sequence 2: NP_001356976.1
• Gene: nmo / 38890
• FlyBaseID: FBgn0011817
• Length: 439
• Species: Drosophila melanogaster
• Alignment Length: 400
• Identity: 148/400 - (37%)
• Similarity: 218/400 - (54%)
• Gaps: 62/400 - (15%)

Human    30 KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTP 94
            :|||.||.|:|.|..|...|..||:|||...||:...:||.:|||.:|....|:|::|.|::..|
  Fly    44 RPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQP 108

Human    95 QKTLEEFQDVYLVMELMDANLCQVI----HMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 155
            .. |:.||::|::.||:.::|.::|    |:..||  :...|||:|.|:|:||||.|:|||:||.
  Fly   109 PH-LDFFQEIYVITELLQSDLHKIIVSPQHLSADH--IKVFLYQILRGLKYLHSARILHRDIKPG 170

Human   156 NIVVKSDCTLKILDFGLARTACTNFM--MTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGE 217
            |::|.|:|.|||.||||||....:..  ||..|||:||||||:::| ..|...||:||||||.||
  Fly   171 NLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGE 235

Human   218 LVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENR-PKYPGIKFEELFPDWIFP 281
            |:...::||..:.:.|...:.|.||||:.|.|:......|.::..| ||.|  .|..|:   ...
  Fly   236 LLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPP--SFSVLY---TLS 295

Human   282 SESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI------------------------- 321
            |.:      |.:|..||.:|||.||||||||.:||.|||:
  Fly   296 SHA------THEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQY 354

Human   322 TVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVK--DQPSDAAVSSN 384
            |..::|:..     |.:|...|.:..::::.||.::|.:   .|:.:.|.|.  ..|..||..|.
  Fly   355 TADFEPSAG-----QPFDDLWERKLTSVQQVKEEMHKFI---AEQLQTGRVPLCINPQSAAFKSF 411

Human   385 AT-----PSQ 389
            |:     ||:
  Fly   412 ASSTVAHPSE 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK9	NP_002743.3	STKc_JNK	25..360	CDD:270840	138/362 (38%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..424		9/28 (32%)
nmo	NP_001356976.1	STKc_NLK	39..411	CDD:173748	144/388 (37%)