DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPK9 and ppk9

DIOPT Version :9

Sequence 1:	NP_001351537.1	Gene:	MAPK9 / 5601	HGNCID:	6886	Length:	424	Species:	Homo sapiens
Sequence 2:	NP_593404.1	Gene:	ppk9 / 2541773	PomBaseID:	SPAC23H4.02	Length:	532	Species:	Schizosaccharomyces pombe

Alignment Length:	395	Identity:	103/395 - (26%)
Similarity:	162/395 - (41%)	Gaps:	107/395 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    51 NVAVKKLSRPFQ-NQTHA---------------KRAYRELVLLKCVNHKNIISLLNVF-TPQKTL 98
            |:|..||.:.|| |:..|               ||..||:.:|:.::|.|||:|..|| .|:.|:
pombe    33 NLAKVKLGKHFQTNEKVALKMVYNDELEDKDTWKRLQREVTILRQLHHPNIITLYQVFRVPKYTV 97

Human    99 EEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS 161
                   |.:|.||.:|..::  |..||......:..|::..|.:.|...:.|||||..||::..
pombe    98 -------LALEYMDTDLHSMVVKHNRLDECTTRKIFRQIVHAIDYCHLHRVAHRDLKLENILLNK 155

Human   162 DCTLKILDFGLARTACTNFMMTPYVV-----TRYYRAPEVILGMGYKE-NVDIWSVGCIMGELVK 220
            |..:|:.||||     :|||:....:     |.:|.|||||.|..|.. :||:|..|.::..::.
pombe   156 DLVVKLTDFGL-----SNFMLDGSFLSTSCGTPHYAAPEVIQGRYYDGCDVDVWGCGILLYLMLV 215

Human   221 GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESE 285
            |...|:..                          |:.|.:....|  ||        :..||
pombe   216 GEFPFEDV--------------------------TISNVLSRVCK--GI--------YTIPS--- 241

Human   286 RDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIE 350
               ..:|.|.||:.:||::.|..||.|.|.::||    |:   .|:.|.    .::|..|..:..
pombe   242 ---FVSSSASDLIRQMLMVLPTSRIKVAEIMQHP----WF---IADLPT----HSRLPSRTSSFS 292

Human   351 EWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSN-ATPSQSSSINDISSMSTEQTLASDTDSSLD 414
                            ||:..|...|.|.|:..: :..|.|||:..|...:....|:.....|:.
pombe   293 ----------------SKHRSVTFSPPDLAILFDPSITSPSSSVGQIPQPTDHSALSPSKPMSIS 341

Human   415 ASTGP 419
            .:..|
pombe   342 GTESP 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK9	NP_001351537.1	STKc_JNK	25..360	CDD:270840	89/333 (27%)
		TXY	183..185		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..424		13/53 (25%)
ppk9	NP_593404.1	STKc_AMPK-like	22..273	CDD:270905	84/297 (28%)
		S_TKc	23..274	CDD:214567	84/298 (28%)
		AMPKA_C_like	426..531	CDD:302605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910