DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cacna1fb and para

DIOPT Version :9

Sequence 1:XP_021333942.1 Gene:cacna1fb / 559964 ZFINID:ZDB-GENE-031104-1 Length:2068 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2268 Identity:510/2268 - (22%)
Similarity:908/2268 - (40%) Gaps:701/2268 - (30%)


- Green bases have known domain annotations that are detailed below.


Zfish    15 EEEGGGEAEEEEEEGGEGGGGGDEGDKEEK-DEWDEEDRPKMNRTETLMSTTSSTATQKKKSQHV 78
            |.|...|.|.:..||.....|..:..||.: |:.||::.|:.:.|             .::...:
  Fly    34 EHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPT-------------LEQGVPI 85

Zfish    79 KKQVQGS-----------------------------NQVQR--APRALYCLKLNNPIRRAALHLV 112
            ..::|||                             ..:.|  |.:|::.|...|||||.|::::
  Fly    86 PVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYIL 150

Zfish   113 EWKPFDIFILLAIFANCVALGVSKPFPEDDSNATNHDLEQVEYVFLIIFTIETFLKILAYGLVMH 177
            ....|.:||:..|..||:.:.:          .|...:|..|.:|..|:|.|:.:|::|.|.::.
  Fly   151 VHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILC 205

Zfish   178 PSSYIRNGWNLLDFVIVIVGLFSVVLETVTHKSGETTSHTPGKPGGLD---VKALRAFRVLRPLR 239
            |.:|:|:.||.||||::.:...::                     |:|   :.|||.|||||.|:
  Fly   206 PFTYLRDAWNWLDFVVIALAYVTM---------------------GIDLGNLAALRTFRVLRALK 249

Zfish   240 LVSGVPSLQIVLNSIMKAMVPLLHISLLVLFVIIIYAIIGLELFIGRMHRTCF----FIG----- 295
            .|:.||.|:.::.::::::..|..:.:|.:|.:.::|::||::::|.:.:.|.    ..|     
  Fly   250 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNL 314

Zfish   296 TDN------------YADDD----PLPCAFAGHGRQC---YVNGSEC-RGKWEGPNGGITNFDNF 340
            ||.            |::|:    ||....:|.| ||   ||    | :|....||.|.|:||:|
  Fly   315 TDENWDYHNRNSSNWYSEDEGISFPLCGNISGAG-QCDDDYV----CLQGFGPNPNYGYTSFDSF 374

Zfish   341 FFAMLTVFQCITMEGWTDVLYWMNDAIGFELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKER 403
            .:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||:::||:|.:::..:.:.:
  Fly   375 GWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 436

Zfish   404 EKAKAR--GDFQKLREKQQ--------MEEDLCGYMDWITQAEDIDEF----------------- 441
            :||:..  .:.:.:||.::        :||...........|...:|.                 
  Fly   437 KKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISY 501

Zfish   442 ----------DEDGNRRVTLRDLADKK-------------------------------------- 458
                      |::...::::|.:..:.                                      
  Fly   502 ELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNI 566

Zfish   459 ---------------RGKFG-------------------WFSHSNETHASLPASE---------- 479
                           ||:||                   ...::::::|..|.||          
  Fly   567 RRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVY 631

Zfish   480 -------------------------------------------TASENTEN-------------- 487
                                                       ..:.||.|              
  Fly   632 YGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLD 696

Zfish   488 ----IDEEHTDCCAACCARIMKI-----PCCRALRRW---------------NRCIRRNCRTAVK 528
                :|....:....|.....||     |....::..               .:...|:.|.:.:
  Fly   697 TNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDR 761

Zfish   529 SVTFY-------------------------------------WL-----VLILVF---------- 541
            .|:.|                                     ||     |.::||          
  Fly   762 GVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITL 826

Zfish   542 ---LNTALSASEHYNQPEWLTDVQDIANKVLLSLFTVEMLLKMYSLGLQVYFVAFFNRFDCFVVC 603
               :||...|.:|::..:.:..|....|....:.|.:|..:|:.::..:.||...:|.||..:|.
  Fly   827 CIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVA 891

Zfish   604 GGILETVLVEMEIMPPLGISVLRCVRLLRIFKVTRHWTALSNLVASLLNSMKSIASLLLLLFLFL 668
            ..:||..|..::     |:||||..||||:||:.:.|..|:.|::.:..:|.::.:|..:|.:.:
  Fly   892 LSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 951

Zfish   669 IIFALLGMQLFGGKFN-----FDETQTKRSTFDSFPQALLTCFQILTGEDWNVVMYDGIMAYGGP 728
            .|||::||||||..::     |.:....|..|..|..:.:..|::|.|| |...|:|       .
  Fly   952 FIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD-------C 1008

Zfish   729 VFPGMIVCL-YFVILFICGNYILLNVFLAIAVDN------------------------------- 761
            ::.|.:.|: :|:...:.||.::||:|||:.:.|                               
  Fly  1009 MYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSW 1073

Zfish   762 ----------------------------------------------------------------- 761
                                                                             
  Fly  1074 VKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILAD 1138

Zfish   762 --------------LAGGD-------GDNKKNEEKK----------------------------E 777
                          :|.||       ||.|.|:.||                            |
  Fly  1139 GLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDE 1203

Zfish   778 GEAEPAEEENGEVKVD-------MDEEYEEEEEPEEGDDEEGKIQLNV----------ADFAP-- 823
            .....||...||.|.|       :|||.:||.|.||| ..:|.|.::.          ||..|  
  Fly  1204 SHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEG-PLDGDIIIHAHDEDILDEYPADCCPDS 1267

Zfish   824 --PKEKILPIPEGSAFFCLSKTNPIRVGCHTLIHHHIFTNLILVFIILSSISLAAED---PIRAH 883
              .|..||...:.|.|:  .....:|:....||.:..|...::..|::||::||.||   |.|  
  Fly  1268 YYKKFPILAGDDDSPFW--QGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQR-- 1328

Zfish   884 SFRNNVLGYADYAFTSIFTVEILLKMTVHGAFLH-EGSFCRNWFNLLDLLVVSVSLVSF---FLH 944
            ....::|.|.|..||.||.:|:|:|....|..:: ..::|  |   ||.::|.|||::|   .:.
  Fly  1329 PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC--W---LDFVIVMVSLINFVASLVG 1388

Zfish   945 SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFK 1009
            :..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|:::|..:...:||.:|||||.
  Fly  1389 AGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1453

Zfish  1010 GKFYRCTDEAKNTPEQCKGTFVVYKDGDVSHPMVRER--------IWLNSDFNFDNVLMGMMALF 1066
            ||:::|        |...||       .:||.::..|        .|:||..|||:|....:.||
  Fly  1454 GKYFKC--------EDMNGT-------KLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLF 1503

Zfish  1067 TVSTFEGWPALLYKAIDANGENHGPIYNYRVEISIFFIVYIIIIAFFMMNIFVGFVIITFREQ-- 1129
            .|:||:||..::..|||:...:..||....:.:.::|:.:||..:||.:|:|:|.:|..|.||  
  Fly  1504 QVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKK 1568

Zfish  1130 ---GEAEFKNCELDKNQRQCVEYALKAQPLKLYIPK---NPVQYKFWSIINSTGFEYVMFVLILL 1188
               |..|....|..|.....::.....:|||. ||:   .| |...:.|:....|:.::.:.|.|
  Fly  1569 KAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKA-IPRPRWRP-QAIVFEIVTDKKFDIIIMLFIGL 1631

Zfish  1189 NTVTLAVQHYDQSKFFSQVMDILNMVFTGLFTVEMIIKLMALRLRHYFVDAWNSFDALIVVGSVV 1253
            |..|:.:..||.|..::.|:|.||.:|..:|:.|.::|:.|||. |||::.||.||.::|:.|::
  Fly  1632 NMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPWNLFDVVVVILSIL 1695

Zfish  1254 DIVVTEFSSSEDSSRVSITFFRLFRVMRLVKLLSKGEGIRTLLWTFVKSLQALPYVALLIAMIFF 1318
            .:|:::.......|...:...|:.:|.|:::|:...:||||||:....||.||..:.||:.::.|
  Fly  1696 GLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1760

Zfish  1319 IYAVIGMQTFGKIAMQDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGKRCDAESDF 1383
            |:|:.||..|  :.:::.:.||...||:||.|:::|||:.:|...|..::.|.:..:.|| ..|.
  Fly  1761 IFAIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACD-PPDN 1822

Zfish  1384 EPGEEFSCGS-NIAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWS 1446
            :.|...:||| .:.|.:.:|:.::...::||:::|||::|:...|.| ...|.....|.:..||.
  Fly  1823 DKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQ 1887

Zfish  1447 EYDPEAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNADGTVTFNATLFALVR 1511
            ::|||....|::..:...|..::|||...|  |::.   ::::|::|:.....:.....|.||.:
  Fly  1888 QFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPICRGDLMYCVDILDALTK 1947

Zfish  1512 TALKIKTDGNPDQENEELRIIIKK------------IWKRTKPKVLDEVIPPPAEEEVTVGKFYA 1564
            .....|  |||.:|..|:..|..:            :|::              .||      |.
  Fly  1948 DFFARK--GNPIEETGEIGEIAARPDTEGYEPVSSTLWRQ--------------REE------YC 1990

Zfish  1565 TFLIQDYFRKFRKRKEKVGLEE----EGNGNPTALQLCQAGLRTLQELGPEMRLAMNEDLEEEEE 1625
            ..|||..:||.:.|.|..|..|    .|:|...     .||       .|....|.:.|.....:
  Fly  1991 ARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDP-----DAG-------DPAPDEATDGDAPAGGD 2043

Zfish  1626 G-----LDEEQEEDDAHYKNENGYAHTEPLSRSRRSSLATTPIGAPVPVPGDGILNGGLGRRSSL 1685
            |     .:...:.|:::..:....|.....:.:..::..||..|:|..        |..||::::
  Fly  2044 GSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGA--------GSAGRQTAV 2100

Zfish  1686 AKTPNGNGALENENFRRRDSMRSSIHYQ-----HKNGVIDQLPKRPSYYKYPRRDSRD 1738
                    .:|::.|..::..:..||.:     .:...:...| ||     |.:|:|:
  Fly  2101 --------LVESDGFVTKNGHKVVIHSRSPSITSRTADVXARP-RP-----PLQDARE 2144

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1fbXP_021333942.1 Ion_trans 114..407 CDD:306908 88/326 (27%)
Ion_trans 532..763 CDD:306908 72/401 (18%)
Ion_trans 856..1093 CDD:306908 84/251 (33%)
Ion_trans 1178..1431 CDD:306908 82/254 (32%)
GPHH 1432..1502 CDD:318993 16/69 (23%)
Ca_chan_IQ 1504..1575 CDD:312334 18/82 (22%)
CAC1F_C 1601..2067 CDD:318975 24/148 (16%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 83/309 (27%)
Na_trans_cytopl 515..648 CDD:288761 9/132 (7%)
Ion_trans 835..1028 CDD:278921 56/205 (27%)
Na_trans_assoc 1054..1296 CDD:284034 36/244 (15%)
Ion_trans 1318..1571 CDD:278921 93/274 (34%)
Na_channel_gate 1561..1613 CDD:240441 14/53 (26%)
Ion_trans 1636..1871 CDD:278921 77/238 (32%)
GPHH 1880..1930 CDD:293510 14/54 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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