Protein Alignment MAPK8 and mapk8a

DIOPT Version :9

• Sequence 1: NP_001265476.1
• Gene: MAPK8 / 5599
• HGNCID: 6881
• Length: 427
• Species: Homo sapiens
• Sequence 2: NP_001103859.1
• Gene: mapk8a / 562720
• ZFINID: ZDB-GENE-080218-17
• Length: 427
• Species: Danio rerio
• Alignment Length: 427
• Identity: 373/427 - (87%)
• Similarity: 402/427 - (94%)
• Gaps: 0/427 - (0%)

Human     1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 65
            |:::||:..||||::||||||||||||||:|||||||||||:|||..||||||||||||||||||
Zfish     1 MNKNKREKEFYSVDVGDSTFTVLKRYQNLRPIGSGAQGIVCSAYDNNLERNVAIKKLSRPFQNQT 65

Human    66 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSY 130
            |||||||||||||||||||||||||||||||:||||||||:|||||||||||||||||||||:||
Zfish    66 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERLSY 130

Human   131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 195
            |||||||||||||:||||||||||||||||||||||||||||||||.|..:||||||||||||||
Zfish   131 LLYQMLCGIKHLHAAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPE 195

Human   196 VILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYV 260
            |||||||:.|||:|||||||.||::|.|||||:||||||||||||||||..||:.||..:|||||
Zfish   196 VILGMGYQANVDVWSVGCIMAEMVRGSVLFPGSDHIDQWNKVIEQLGTPTQEFLLKLNQSVRTYV 260

Human   261 ENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWY 325
            ||||:|.|||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Zfish   261 ENRPRYTGYSFEKLFPDVLFPADSEHSKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWY 325

Human   326 DPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHP 390
            ||:|.|||.|.|.||||||||||:|||||||||||:|.|||.||||||||||||||||||||..|
Zfish   326 DPAEVEAPSPLITDKQLDEREHTVEEWKELIYKEVLDWEERMKNGVIRGQPSPLGAAVINGSPQP 390

Human   391 SSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR 427
            |||||:||||||||:||:||||||||||:||||.|||
Zfish   391 SSSSSINDVSSMSTEPTVASDTDSSLEASAGPLSCCR 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK8	NP_001265476.1	STKc_JNK	25..360	CDD:270840	298/334 (89%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..427		48/55 (87%)
mapk8a	NP_001103859.1	STKc_JNK	25..360	CDD:270840	298/334 (89%)
		S_TKc	26..321	CDD:214567	264/294 (90%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332219
Domainoid	1	1.000	190	1.000	Domainoid score	I13676
eggNOG	1	0.900	-	-		E1_KOG0665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56760
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D193969at7742
OrthoFinder	1	1.000	-	-		FOG0001812
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103172
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4615
SonicParanoid	1	1.000	-	-		X1172
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.280