DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPK8 and bsk

DIOPT Version :9

Sequence 1:	NP_001265476.1	Gene:	MAPK8 / 5599	HGNCID:	6881	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_001162930.1	Gene:	bsk / 44801	FlyBaseID:	FBgn0000229	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	364	Identity:	290/364 - (79%)
Similarity:	322/364 - (88%)	Gaps:	1/364 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    11 YSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELV 75
            |:||:||:.||:..||.||:|||||||||||||||.|.::|||||||||||||.|||||||||..
  Fly     9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73

Human    76 LMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 140
            |||.|||||||||||.||||::||||||||:|||||||||||||||:|||:||||||||||||||
  Fly    74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138

Human   141 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205
            ||||||||||||||||||||:|||||||||||||||||:|||||||||||||||||||||||.||
  Fly   139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTEN 203

Human   206 VDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYS 270
            ||||||||||||||:||||||||||||||||:|||||||.|.||::||||||.||||||:|.|||
  Fly   204 VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYS 268

Human   271 FEKLFPDVLFPADSEHN-KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPP 334
            |::||||.|||.|:..| :.|||.||:|||||||||..:||||||||:|.|||||||..|.:||.
  Fly   269 FDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPA 333

Human   335 PKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIR 373
            |:..|..:||||||:|:||||||:||||.|....|...|
  Fly   334 PEPYDHSVDEREHTVEQWKELIYEEVMDYEAHNTNNRTR 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK8	NP_001265476.1	STKc_JNK	25..360	CDD:270840	276/335 (82%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..427		1/3 (33%)
bsk	NP_001162930.1	STKc_JNK	23..359	CDD:270840	276/335 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	504	1.000	Domainoid score	I334
eggNOG	1	0.900	-	-		E1_KOG0665
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56760
Inparanoid	1	1.050	594	1.000	Inparanoid score	I977
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D295851at33208
OrthoFinder	1	1.000	-	-		FOG0001812
OrthoInspector	1	1.000	-	-		otm40681
orthoMCL	1	0.900	-	-		OOG6_103172
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4615
SonicParanoid	1	1.000	-	-		X1172
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860