Protein Alignment MAPK8 and nmo

DIOPT Version :10

• Sequence 1: NP_620637.1
• Gene: MAPK8 / 5599
• HGNCID: 6881
• Length: 427
• Species: Homo sapiens
• Sequence 2: NP_001356976.1
• Gene: nmo / 38890
• FlyBaseID: FBgn0011817
• Length: 439
• Species: Drosophila melanogaster
• Alignment Length: 411
• Identity: 145/411 - (35%)
• Similarity: 218/411 - (53%)
• Gaps: 62/411 - (15%)

Human    30 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTP 94
            :|||.||.|:|.|..|....|.||:|||...||:...:||.:|||.::....|:|::..|::..|
  Fly    44 RPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQP 108

Human    95 QKSLEEFQDVYIVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 155
             ..|:.||::|::.||:.::|.::|    .:..||  :...|||:|.|:|:||||.|:|||:||.
  Fly   109 -PHLDFFQEIYVITELLQSDLHKIIVSPQHLSADH--IKVFLYQILRGLKYLHSARILHRDIKPG 170

Human   156 NIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGE 217
            |::|.|:|.|||.||||||.  ...:..||..|||:||||||:::| ..|...||:||||||.||
  Fly   171 NLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGE 235

Human   218 MVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENR-PKYAGYSFEKLFPDVLFP 281
            ::..:|||..::.:.|...:.|.||||..|.|:......||::..| ||...:|       ||:.
  Fly   236 LLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFS-------VLYT 293

Human   282 ADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN------------------------ 322
            ..|.    ...:|..||.:|||.|..|||||.:||.|||::
  Fly   294 LSSH----ATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQY 354

Human   323 -VWYDPSEAEAPPPKIPDKQLDEREHT-IEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVIN 385
             ..::||..:      |...|.||:.| :::.||.::|.:   .|:.:.|.:....:|..||.
  Fly   355 TADFEPSAGQ------PFDDLWERKLTSVQQVKEEMHKFI---AEQLQTGRVPLCINPQSAAF-- 408

Human   386 GSQHPSSSSSVNDVSSMSTDP 406
               ...:||:|...|.:...|
  Fly   409 ---KSFASSTVAHPSELPPSP 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK8	NP_620637.1	STKc_JNK	25..360	CDD:270840	135/363 (37%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..427		8/36 (22%)
nmo	NP_001356976.1	STKc_NLK	39..411	CDD:173748	140/394 (36%)