DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPK8 and lkh1

DIOPT Version :9

Sequence 1:	NP_001265476.1	Gene:	MAPK8 / 5599	HGNCID:	6881	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_001018187.2	Gene:	lkh1 / 3361532	PomBaseID:	SPAC1D4.11c	Length:	690	Species:	Schizosaccharomyces pombe

Alignment Length:	370	Identity:	104/370 - (28%)
Similarity:	159/370 - (42%)	Gaps:	90/370 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     7 DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAY 71
            |:..|.| :.:|.|.  .||..::.:|.|..|.|...||....|:.|||        .|.|...|
pombe   346 DDGHYKV-VPNSKFA--NRYTVVRLLGHGTFGKVIQCYDQSTGRHCAIK--------VTRAIPKY 399

Human    72 RELVLMKC-----------VNHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDANLCQVIQMEL 123
            ||..|::.           .|....|.|.:.|..:|.:....|::  .|.:.:..|  ..|...|
pombe   400 REASLIELRVLQTIAHSDPTNENKCIQLRDYFDYRKHICIVTDLFGWSVFDFLKNN--NYIPFPL 462

Human   124 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD-------------------CTLKILD 169
            .|.:|  |..|:...:..|||.|::|.||||.|:::.|:                   |.::::|
pombe   463 KHIQM--LSQQLFKSVAFLHSLGLVHTDLKPENVLLVSNASRTIRLPYRNYSQKVLNSCEIRLID 525

Human   170 FGLARTAGTSF---MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLF---PGT 228
            ||.|     :|   ..:..|.||:|||||:|||:|:....|:||:|||:.|:..|..||   ..:
pombe   526 FGSA-----TFEDEYHSSVVSTRHYRAPEIILGLGWSYPCDVWSIGCILVELFTGQALFQTHEDS 585

Human   229 DHIDQWNKV--------IEQLGTPCPEFMKKLQPTVRTYVENRPKYA-GY-----SFEKLF---- 275
            :|:....|:        |.:.......|.|. ...||..:.|.||.: .|     :.|::|
pombe   586 EHLCMMEKILGPFDRNMISRSSRTSQRFFKS-DGKVRYPLSNTPKKSINYLQSLQTLEQIFAVSS 649

Human   276 PDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPY 320
            |:|             :...|||.|:.|.|..:||:..|||.||:
pombe   650 PEV-------------ALLLDLLKKVFVYDPKRRITAKEALWHPF 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK8	NP_001265476.1	STKc_JNK	25..360	CDD:270840	99/352 (28%)
		TXY	183..185		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..427
lkh1	NP_001018187.2	E_Pc_C	<104..198	CDD:284226
		PKc_CLK	349..682	CDD:271036	103/367 (28%)
		S_TKc	362..682	CDD:214567	98/351 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910