Protein Alignment MAPK8 and CG8565

DIOPT Version :10

• Sequence 1: NP_620637.1
• Gene: MAPK8 / 5599
• HGNCID: 6881
• Length: 427
• Species: Homo sapiens
• Sequence 2: NP_573080.1
• Gene: CG8565 / 32538
• FlyBaseID: FBgn0030697
• Length: 790
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 117/642 - (18%)
• Similarity: 194/642 - (30%)
• Gaps: 292/642 - (45%)

Human    10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL 74
            ::.|.|||   ..:.||...|.:|.|....|...||..::|..|: |:|:  ..|.:.:....|:
  Fly   190 YHPVAIGD---VFVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAV-KVSK--SAQVYKETGIDEI 248

Human    75 VLMKCVN----HK---NIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSY-- 130
            :|...::    ||   :::|..:.|  :.:....:.:.:|:|::..||.:||      ||..|
  Fly   249 MLFSQMSLHDQHKYRSHVVGFYDFF--EITGPHGRHICLVLEVLGDNLLKVI------ERCFYKG 305

Human   131 --------LLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKS------------------------- 161
                    :..|:|.|:|.|| ..||||.||||.|:::.|
  Fly   306 MPISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVSVRTEIKTAIEVYLKANEGKLS 370

Human   162 ----------------------------------------------------------------- 161
                                                                             
  Fly   371 PSSKMTKTAKRRMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAERGLIEPITAAMAVSDNLPFIP 435

Human   162 ------------DC-----------------------TLK--------ILDF------------- 170
                        ||                       .||        :||.
  Fly   436 FGFDGFMMMSDADCRTVQNSKLPEMEGMEYKCDRINLCLKSPELFLRYVLDIIKNLDEKELSTQD 500

Human   171 --------------------------GLARTAGTSFM---------------------------- 181
                                      ..|.|.||.:.
  Fly   501 KRRRFTQASGRGQTKKNARSRLRLASNAAYTTGTGWRSNRKINLNDIYPIDPANNECDVRVKIAD 565

Human   182 ----------MTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFP-----GRDYI 231
                      .|..:.|:.|||.|||||.||.|..|:|||.|::.|:.....||.     |:..:
  Fly   566 LGNACYFHHHFTDDIQTKEYRALEVILGAGYCETADIWSVACLLWELATGTYLFDTHSKRGKYNL 630

Human   232 DQWN--KVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFP----DVLFPADSEHNKLK 290
            |:.:  |::|..|. .|.::.:.....|.::.:..|..  :.|.|.|    ::|........: :
  Fly   631 DEVHIAKIVETCGR-IPWYLIRKGKHSRNFINSAGKLC--NIETLKPLKLANILIRWYGWRTR-Q 691

Human   291 ASQARDLLSKMLVIDASKRISVDEALQHPYI-NVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKE 354
            :::..:.|..||..:...|||..:||:..|: |:            .:|...:|          .
  Fly   692 STEFVNFLMPMLQTNPLSRISASKALESHYLCNI------------ALPGIDID----------S 734

Human   355 LIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASD 411
            ..|..|.::::.|.....|           |..:..||.||: |.|..|:|.....|
  Fly   735 YYYYSVREIKDCTHTKSER-----------NSDEDSSSCSSI-DSSEFSSDEVCYED 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK8	NP_620637.1	STKc_JNK	25..360	CDD:270840	100/574 (17%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..427		11/41 (27%)
CG8565	NP_573080.1	Protein Kinases, catalytic domain	192..722	CDD:473864	99/547 (18%)