DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPK8 and spk1

DIOPT Version :9

Sequence 1:	NP_001265476.1	Gene:	MAPK8 / 5599	HGNCID:	6881	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_594009.1	Gene:	spk1 / 2542474	PomBaseID:	SPAC31G5.09c	Length:	372	Species:	Schizosaccharomyces pombe

Alignment Length:	354	Identity:	136/354 - (38%)
Similarity:	204/354 - (57%)	Gaps:	24/354 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    17 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 81
            |..|.:.:.|:.:..||.||.|:||||........||:||: .||.:.....|..||:.|::...
pombe    30 DLNFELPEEYEMINLIGQGAYGVVCAALHKPSGLKVAVKKI-HPFNHPVFCLRTLREIKLLRHFR 93

Human    82 HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSA 145
            |:|||.:|::. |..|.:|.:|||||.|||:.:|.:||:.: |..:...|..||:|..:|.:|||
pombe    94 HENIISILDIL-PPPSYQELEDVYIVQELMETDLYRVIRSQPLSDDHCQYFTYQILRALKAMHSA 157

Human   146 GIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMTPYVVTRYYRAPEVILGM-GYKEN 205
            |::||||||||:::.::|.||:.||||||:    .|....||.||.||:|||||::|.. .|.:.
pombe   158 GVVHRDLKPSNLLLNANCDLKVADFGLARSTTAQGGNPGFMTEYVATRWYRAPEIMLSFREYSKA 222

Human   206 VDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP-CPEFMKKLQPTVRTYVENRPKYAGY 269
            :|:||.|||:.||:....||||.|:..|...::..|||| ..:|.:......|.|:::.|.....
pombe   223 IDLWSTGCILAEMLSARPLFPGKDYHSQITLILNILGTPTMDDFSRIKSARARKYIKSLPFTPKV 287

Human   270 SFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSE---AE 331
            ||:.|||..            :..|.|||.|:|..:..|||:.:|||:|||:..::|.|:   |.
pombe   288 SFKALFPQA------------SPDAIDLLEKLLTFNPDKRITAEEALKHPYVAAYHDASDEPTAS 340

Human   332 APPPKIPDKQLDEREHTIEEWKELIYKEV 360
            ..||.:.|...::.:..|...|.||::||
pombe   341 PMPPNLVDLYCNKEDLEIPVLKALIFREV 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK8	NP_001265476.1	STKc_JNK	25..360	CDD:270840	132/344 (38%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..427
spk1	NP_594009.1	STKc_ERK1_2_like	33..371	CDD:270839	135/351 (38%)
spk1	NP_594009.1	S_TKc	39..327	CDD:214567	121/301 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910