DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAPK7 and mapk7

DIOPT Version :9

Sequence 1:	XP_006721620.1	Gene:	MAPK7 / 5598	HGNCID:	6880	Length:	822	Species:	Homo sapiens
Sequence 2:	XP_005156059.1	Gene:	mapk7 / 541323	ZFINID:	ZDB-GENE-050320-10	Length:	1080	Species:	Danio rerio

Alignment Length:	1091	Identity:	484/1091 - (44%)
Similarity:	584/1091 - (53%)	Gaps:	316/1091 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     3 EPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYG 67
            |.:::....:|.|:|..........|  :||.||||||||.|.||.|:|||||:||||||.||||
Zfish    30 EKVQQRGVTEGPAQPSNDTSTVTDDT--TVADKNLALLKAHSLDVKFEVGDEYDIIETIGTGAYG 92

Human    68 VVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKS 132
            ||||||||..|||||||||||||:||||||||||||||||||||||||||||||:|.||:..|||
Zfish    93 VVSSARRRDNGQQVAIKKIPNAFEVVTNAKRTLRELKILKHFKHDNIIAIKDILQPVVPHSAFKS 157

Human   133 VPYGVPGYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN 197
            |      |||||||||||||||||.||||.||.|||||||||||||:|||.||||||||||||||
Zfish   158 V------YVVLDLMESDLHQIIHSRQPLTPEHTRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVN 216

Human   198 ENCELKIGDFGMARGL-CTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEM 261
            |||||||||||||||| .....|.:.|||||||||||||||||||||.|:.||||||||||||||
Zfish   217 ENCELKIGDFGMARGLSAVYSEESRSFMTEYVATRWYRAPELMLSLHHYSLAIDLWSVGCIFGEM 281

Human   262 LARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQA 326
            |.|||:|||||||||||||:.|||||..:::.::|::|||:|::|||.:.|.|...:||.|:..|
Zfish   282 LGRRQMFPGKNYVHQLQLILSVLGTPPESIVGSIGSDRVRSYVRSLPSKAPEPLAALYPQAEPSA 346

Human   327 LSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEI 391
            |:||..||||:|..||||..||.||:|:|||||||||.|.|.|:|.|||:.:.:|:|||||:.||
Zfish   347 LNLLAAMLRFDPRERISACQALEHPYLSKYHDPDDEPVCVPAFNFEFDRQPMGKEQIKEAILTEI 411

Human   392 EDFHARREGIRQQIRFQP------SLQPVASEP-------------------------------- 418
            :|||.:::|:|::|:|:|      :|..|:|..
Zfish   412 QDFHKKKQGVRKKIQFKPLHSSGSALVGVSSNSHCTAQQSQHLKEMSQTHQQHSLNFKPADTTQM 476

Human   419 ----------------------GCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTL-- 459
                                  .|.||:|||..:..                  .|:|||||.
Zfish   477 NVNSFQTPHLIGQILPHLEQSVSCQDVDMPSANSDG------------------QPETIDLTTPT 523

Human   460 -------------------------------QPPP---PVSEPA--------------------- 469
                                           |.||   |.|.|:
Zfish   524 DKDTSFTEPAIDCRKDKSVLSNYTAPSRSVSQTPPTSLPQSVPSLSLSQSQVQSLSQNLSRSLGK 588

Human   470 --------PPKKDGAISDNTKAALKAALLKS-LRSRLRDGPSAPL-------------------- 505
                    ..||:||||::|||||||||.|| ||.:.||..:|.|
Zfish   589 GGKPTAAEGTKKEGAISEDTKAALKAALQKSALRQKARDEGTAALGIDLVRGASVGLSSSISSSN 653

Human   506 EAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDN 570
            ..||.|:|:|||||||||||||::|||||.||:::.:|:|:||       |...:.|.|::||||
Zfish   654 SCPEQRRPITAQERQREREEKRKKRQERAMERKRKLKEKEKKE-------GKHGESLGGVLLSDN 711

Human   571 DRSLLERWTRMA-RPA--------APALTSVPAPAPAPTPTPT--------------PVQPTS-- 610
            |:.||:||.||. :||        :.|.||....|.....|..              |.||..
Zfish   712 DKMLLQRWVRMMDKPADKSQGIETSNAKTSDSNMAQIQPATGNNIIKTNSNGGESVLPKQPNKAQ 776

Human   611 --PPPGPVAQ-----------PTGPQPQS------------------------------------ 626
              .||..|:|           ||.....|
Zfish   777 VFKPPQLVSQMGQCVTAGLFYPTSTHDASVPLGQAQNGDVGIVAGVGSVGGLGMVTAPCAFAKNN 841

Human   627 -----------------AGSTSGPVPQPACPP----PGPAPHPTGPPGPIPV---PAPP----QI 663
                             .|::|....||  ||    ||.|..||.......|   |..|    |.
Zfish   842 ILKSQFVGTVFTGLENWTGTSSHKTHQP--PPELNNPGFAHMPTHSKPNTHVQLLPLEPFMNKQS 904

Human   664 ATSTSLLA------AQSLVPPPGLP----------GSSTPGVLPYFPPGLPPPDAGGAPQSSMSE 712
            |.:|.:..      |:|...|..|.          ||.:.|      ....||.|...|..|:::
Zfish   905 ALNTGIRVSDTSTNAESRDGPQALEKLCFLGERQNGSHSQG------SSRQPPGAAVQPCLSLTD 963

Human   713 S-------PDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQ 770
            :       ||::.||||||||||||.||||||.|||||||||||||||::.|.||.........:
Zfish   964 TGQSSNSIPDIHTVTQQLSKSQVEDILPPVFSVTPKGSGAGYGVGFDLDDLLTQSLTELQHSDLR 1028

Human   771 DGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLAD---LPD 818
            :...|.|.||||||:||||.|.|.|||:||||:|:|:.|||:|:|   |||
Zfish  1029 ESHNDLAPLSASLLSDWLEVHRMTPADMESLQQELQLGSPMILSDNSTLPD 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK7	XP_006721620.1	STKc_ERK5	49..390	CDD:270842	255/341 (75%)
MAPK7	XP_006721620.1	S_TKc	55..353	CDD:214567	227/298 (76%)
mapk7	XP_005156059.1	STKc_ERK5	74..410	CDD:270842	255/341 (75%)
mapk7	XP_005156059.1	S_TKc	80..373	CDD:214567	227/298 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337226
Domainoid	1	1.000	458	1.000	Domainoid score	I3417
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2060
Inparanoid	1	1.050	820	1.000	Inparanoid score	I3350
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45174
OrthoDB	1	1.010	-	-		D139811at7742
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	1	1.000	-	-		oto48451
orthoMCL	1	0.900	-	-		OOG6_100339
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X259
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.270