Protein Alignment MAPK7 and mapk7

DIOPT Version :10

• Sequence 1: XP_006721620.1
• Gene: MAPK7 / 5598
• HGNCID: 6880
• Length: 822
• Species: Homo sapiens
• Sequence 2: XP_073773710.1
• Gene: mapk7 / 541323
• ZFINID: ZDB-GENE-050320-10
• Length: 1088
• Species: Danio rerio
• Alignment Length: 1091
• Identity: 484/1091 - (44%)
• Similarity: 584/1091 - (53%)
• Gaps: 316/1091 - (28%)

Human     3 EPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYG 67
            |.:::....:|.|:|..........|  :||.||||||||.|.||.|:|||||:||||||.||||
Zfish    38 EKVQQRGVTEGPAQPSNDTSTVTDDT--TVADKNLALLKAHSLDVKFEVGDEYDIIETIGTGAYG 100

Human    68 VVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKS 132
            ||||||||..|||||||||||||:||||||||||||||||||||||||||||||:|.||:..|||
Zfish   101 VVSSARRRDNGQQVAIKKIPNAFEVVTNAKRTLRELKILKHFKHDNIIAIKDILQPVVPHSAFKS 165

Human   133 VPYGVPGYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN 197
            |      |||||||||||||||||.||||.||.|||||||||||||:|||.||||||||||||||
Zfish   166 V------YVVLDLMESDLHQIIHSRQPLTPEHTRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVN 224

Human   198 ENCELKIGDFGMARGL-CTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEM 261
            |||||||||||||||| .....|.:.|||||||||||||||||||||.|:.||||||||||||||
Zfish   225 ENCELKIGDFGMARGLSAVYSEESRSFMTEYVATRWYRAPELMLSLHHYSLAIDLWSVGCIFGEM 289

Human   262 LARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQA 326
            |.|||:|||||||||||||:.|||||..:::.::|::|||:|::|||.:.|.|...:||.|:..|
Zfish   290 LGRRQMFPGKNYVHQLQLILSVLGTPPESIVGSIGSDRVRSYVRSLPSKAPEPLAALYPQAEPSA 354

Human   327 LSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEI 391
            |:||..||||:|..||||..||.||:|:|||||||||.|.|.|:|.|||:.:.:|:|||||:.||
Zfish   355 LNLLAAMLRFDPRERISACQALEHPYLSKYHDPDDEPVCVPAFNFEFDRQPMGKEQIKEAILTEI 419

Human   392 EDFHARREGIRQQIRFQP------SLQPVASEP-------------------------------- 418
            :|||.:::|:|::|:|:|      :|..|:|..
Zfish   420 QDFHKKKQGVRKKIQFKPLHSSGSALVGVSSNSHCTAQQSQHLKEMSQTHQQHSLNFKPADTTQM 484

Human   419 ----------------------GCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTL-- 459
                                  .|.||:|||..:..                  .|:|||||.
Zfish   485 NVNSFQTPHLIGQILPHLEQSVSCQDVDMPSANSDG------------------QPETIDLTTPT 531

Human   460 -------------------------------QPPP---PVSEPA--------------------- 469
                                           |.||   |.|.|:
Zfish   532 DKDTSFTEPAIDCRKDKSVLSNYTAPSRSVSQTPPTSLPQSVPSLSLSQSQVQSLSQNLSRSLGK 596

Human   470 --------PPKKDGAISDNTKAALKAALLKS-LRSRLRDGPSAPL-------------------- 505
                    ..||:||||::|||||||||.|| ||.:.||..:|.|
Zfish   597 GGKPTAAEGTKKEGAISEDTKAALKAALQKSALRQKARDEGTAALGIDLVRGASVGLSSSISSSN 661

Human   506 EAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDN 570
            ..||.|:|:|||||||||||||::|||||.||:::.:|:|:||       |...:.|.|::||||
Zfish   662 SCPEQRRPITAQERQREREEKRKKRQERAMERKRKLKEKEKKE-------GKHGESLGGVLLSDN 719

Human   571 DRSLLERWTRMA-RPA--------APALTSVPAPAPAPTPTPT--------------PVQPTS-- 610
            |:.||:||.||. :||        :.|.||....|.....|..              |.||..
Zfish   720 DKMLLQRWVRMMDKPADKSQGIETSNAKTSDSNMAQIQPATGNNIIKTNSNGGESVLPKQPNKAQ 784

Human   611 --PPPGPVAQ-----------PTGPQPQS------------------------------------ 626
              .||..|:|           ||.....|
Zfish   785 VFKPPQLVSQMGQCVTAGLFYPTSTHDASVPLGQAQNGDVGIVAGVGSVGGLGMVTAPCAFAKNN 849

Human   627 -----------------AGSTSGPVPQPACPP----PGPAPHPTGPPGPIPV---PAPP----QI 663
                             .|::|....||  ||    ||.|..||.......|   |..|    |.
Zfish   850 ILKSQFVGTVFTGLENWTGTSSHKTHQP--PPELNNPGFAHMPTHSKPNTHVQLLPLEPFMNKQS 912

Human   664 ATSTSLLA------AQSLVPPPGLP----------GSSTPGVLPYFPPGLPPPDAGGAPQSSMSE 712
            |.:|.:..      |:|...|..|.          ||.:.|      ....||.|...|..|:::
Zfish   913 ALNTGIRVSDTSTNAESRDGPQALEKLCFLGERQNGSHSQG------SSRQPPGAAVQPCLSLTD 971

Human   713 S-------PDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQ 770
            :       ||::.||||||||||||.||||||.|||||||||||||||::.|.||.........:
Zfish   972 TGQSSNSIPDIHTVTQQLSKSQVEDILPPVFSVTPKGSGAGYGVGFDLDDLLTQSLTELQHSDLR 1036

Human   771 DGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLAD---LPD 818
            :...|.|.||||||:||||.|.|.|||:||||:|:|:.|||:|:|   |||
Zfish  1037 ESHNDLAPLSASLLSDWLEVHRMTPADMESLQQELQLGSPMILSDNSTLPD 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK7	XP_006721620.1	STKc_ERK5	49..390	CDD:270842	255/341 (75%)
mapk7	XP_073773710.1	None