Protein Alignment BAIAP2L1 and IRSp53

DIOPT Version :10

• Sequence 1: NP_061330.2
• Gene: BAIAP2L1 / 55971
• HGNCID: 21649
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Alignment Length: 676
• Identity: 149/676 - (22%)
• Similarity: 251/676 - (37%)
• Gaps: 217/676 - (32%)

Human     6 EEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTE 70
            |||.:|.:..|||::::||||.|.||..||:|.||::....|.:.:.:.:|||...|..|... :
  Fly     4 EEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQSGTG-D 67

Human    71 LGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEK 135
            :|..|:.:.:.:|::.:......|.|:.:::..||..:|.|.|.:....|::..:||.::||.:|
  Fly    68 IGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQK 132

Human   136 SQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKH 200
            :.:.:||.|:|.....|.    .||:..::.:..::.::..|.....|.|:.:|:||:.|::::.
  Fly   133 AVSTMKKQRKKKATPENT----EKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQ 193

Human   201 CGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPA--------------- 250
            |..|.|...||.....::::....|||....            .||..||
  Fly   194 CSIAKHWMVYHTTGKTVIDNNFENWQEIAAS------------REIIPPAAYESGYSTSNGHNNN 246

Human   251 ---STPVSGTPQASPMIERSNVVRK-DYDTLSKCSPKMPPAPSGRAYTSPLIDM----------- 300
               |:..||....|..:.|...::. |.|.|.....::   ...|:..:|..||
  Fly   247 NISSSSSSGNNNTSGNMRRLERIKDGDDDHLQGHGAQL---KKSRSIDAPYGDMRTLHERENLSG 308

Human   301 --FNNPATAAPNSQRVNNSTGTSEDPSLQRSVS------VATGLNMMKKQK-------------- 343
              ...||..|.|              ||.|:.|      |.||.:...|.|
  Fly   309 LGGTGPAHYAQN--------------SLPRAKSDFNLALVGTGQSSANKHKIIEEQLATLGDDQR 359

Human   344 ------VKTIFPH-TAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYT---- 397
                  ||.::.: .:|.|:  |||.:||.|.|:..:.| ||.:||:..::..||||.:||
  Fly   360 GDQRPLVKALYAYMPSGENQ--LSFEEGDRIALVGGKAK-GWQFGENLRTQHFGWFPVAYTNAEV 421

Human   398 -----------------------------------------------KLLEENET---------- 405
                                                           :|:|.:|.
  Fly   422 AEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQQQDYEAQLELMESHEATYRRRRNHSA 486

Human   406 ------------------------------EAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYL 440
                                          ...|:|.|.|...:|.|:..|:.:.|.
  Fly   487 EDSSPTRMFGDTIKQQKKYRPGSGANPRPGPPPTLPAPVPNGPQSQSSRMLNSSQSF-------- 543

Human   441 ECLSMG----AAADRR-------ADSARTTSTFKA-PASKPETAAPNDANGTAKPP-----FLSG 488
             |.|.|    ||.:||       ..|::...:.|: .|:|....:.||:....:||     ..|.
  Fly   544 -CASNGGGVNAAVERRKQKLLNGVQSSKNHPSGKSGVAAKTSLHSSNDSGFANEPPPQPEVDYSD 607

Human   489 ENPFATVKL---RPTVTNDRSAPIIR 511
            |.| ||.::   |...||..:..:.|
  Fly   608 EEP-ATQRVAIRRRADTNSHTNTVPR 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BAIAP2L1	NP_061330.2	I-BAR_IMD_BAIAP2L1	6..231	CDD:153329	63/224 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..328		6/25 (24%)
		SH3_BAIAP2L1	342..399	CDD:212846	23/128 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..511		18/75 (24%)
		Binds F-actin	483..511		10/35 (29%)
		WH2	<495..510	CDD:425359	3/17 (18%)
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	63/222 (28%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	22/57 (39%)