DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MAPK6 and rl

DIOPT Version :9

Sequence 1:NP_002739.1 Gene:MAPK6 / 5597 HGNCID:6879 Length:721 Species:Homo sapiens
Sequence 2:NP_001015122.1 Gene:rl / 3354888 FlyBaseID:FBgn0003256 Length:376 Species:Drosophila melanogaster


Alignment Length:347 Identity:156/347 - (44%)
Similarity:214/347 - (61%) Gaps:27/347 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS-VKHALREIKIIRRLDHDNI 77
            |::|.||:.|..:|.|..|:|.||.|...::|||||||...:.|: .:..||||.|:.|..|:||
  Fly    32 FEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENI 96

Human    78 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKY 142
            :.:.:||         .|.|:.::..|||||..|||||..:|:...|..:|...|:||:||||||
  Fly    97 IDIRDIL---------RVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKY 152

Human   143 IHSANVLHRDLKPANLFIN-TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSP 206
            |||||||||||||:||.:| |.|  |||.|||||||.||.:.|.|.|:|.:.|:|||:|.::|:.
  Fly   153 IHSANVLHRDLKPSNLLLNKTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 215

Human   207 NNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDM 271
            ..|||:||:|:.|||.||||:.:.:|.|.|.|:|:..||   .|:....|.:|..:|....||.:
  Fly   216 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL---GVLGSPSRDDLECIINEKARNYL 277

Human   272 T----EPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPF 332
            .    :|:.|..:|.|.....|||.|.::|||:|..|:..||||:|||:..|..|.|||::..||
  Fly   278 ESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPF 342

Human   333 HIEDEVDDI-------LLMDET 347
            .|..|.|||       |:.:||
  Fly   343 RINMENDDISRDALKSLIFEET 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAPK6NP_002739.1 STKc_MAPK4_6 14..355 CDD:143359 156/347 (45%)
SEG motif 189..191 0/1 (0%)
FRIEDE motif 332..337 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..721
rlNP_001015122.1 STKc_ERK1_2_like 32..366 CDD:270839 156/347 (45%)
S_TKc 38..326 CDD:214567 137/301 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0660
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D741207at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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