DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPK4 and p38a

DIOPT Version :9

Sequence 1:	NP_002738.2	Gene:	MAPK4 / 5596	HGNCID:	6878	Length:	587	Species:	Homo sapiens
Sequence 2:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster

Alignment Length:	327	Identity:	120/327 - (36%)
Similarity:	184/327 - (56%)	Gaps:	30/327 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    20 FVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDNIVKVYE 82
            :.|.||:|.|..|.|..||.......||:||:|  ...|...|...||:::::.:||:|::.:.:
  Fly    25 YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLD 89

Human    83 VLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLH 147
            :..|...:  |.|..|...|:|...|:.||..::....|:::|.:..:||:||||||||||.|:|
  Fly    90 IFHPHPAN--GSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQILRGLKYIHSAGVIH 152

Human   148 RDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDM 212
            |||||:||.:: ||..|:|.||||||..:...:  ||::    |:|||:|.::|:..:|.:.:|:
  Fly   153 RDLKPSNIAVN-EDCELRILDFGLARPTENEMT--GYVA----TRWYRAPEIMLNWMHYDQTVDI 210

Human   213 WAAGCILAEMLTGRMLFAGAHELEQMQLILE---TIPVIREEDKDELLRVMP-----SFVSSTWE 269
            |:.|||:||::|.|.||.|...:.|:.||:|   |.|.       |.|:.:.     |::.|...
  Fly   211 WSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPA-------EFLKKISSESARSYIQSLPP 268

Human   270 VK-RPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTS---QHPFRI 330
            :| |..:.:....|..|||.|||:|..:...|:|||..|.|||:..|:.|..|.||   .|.|..
  Fly   269 MKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSPPYDHSFED 333

Human   331 ED 332
            .|
  Fly   334 MD 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK4	NP_002738.2	STKc_MAPK4_6	14..351	CDD:143359	120/327 (37%)
		SEG motif	186..188		0/1 (0%)
		FRIEDE motif	328..333		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..534
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	120/327 (37%)
p38a	NP_001163711.1	S_TKc	25..312	CDD:214567	111/302 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810