DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPK4 and p38b

DIOPT Version :9

Sequence 1:	NP_002738.2	Gene:	MAPK4 / 5596	HGNCID:	6878	Length:	587	Species:	Homo sapiens
Sequence 2:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	120/325 - (36%)
Similarity:	183/325 - (56%)	Gaps:	33/325 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
            :::...:.:.||:|.|..|.|..||......|||:||:|  ...|...|...||:::::.:||:|
  Fly    18 WEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHEN 82

Human    77 IVKVYEVLGP-KGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYI 140
            ::.:.:|..| :..|   .|.:|...|:|...|:.||..::....|:::|.:..:||:|||||||
  Fly    83 VIGLLDVFHPGQPAD---SLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQILRGLKYI 144

Human   141 HSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNN 205
            |||.|:||||||:||.:: ||..|:|.||||||..:...:  ||::    |:|||:|.::|:..:
  Fly   145 HSAGVIHRDLKPSNIAVN-EDCELRILDFGLARPAESEMT--GYVA----TRWYRAPEIMLNWMH 202

Human   206 YTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL-----------LRV 259
            |.:..|:|:.|||:||:||||.||.|...:.|:.||:|.:....:|....:           |.|
  Fly   203 YNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPV 267

Human   260 MPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTS 324
            ||         :|..|.:....|..|||.|||:|..:...|:|||..|.||||..|..|.||.|:
  Fly   268 MP---------RRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTA 323

Human 325 324
Fly 324 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK4	NP_002738.2	STKc_MAPK4_6	14..351	CDD:143359	120/325 (37%)
		SEG motif	186..188		0/1 (0%)
		FRIEDE motif	328..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..534
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	120/325 (37%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	113/305 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810