Protein Alignment MAPK4 and p38b

DIOPT Version :10

• Sequence 1: NP_002738.2
• Gene: MAPK4 / 5596
• HGNCID: 6878
• Length: 587
• Species: Homo sapiens
• Sequence 2: NP_477361.1
• Gene: p38b / 34780
• FlyBaseID: FBgn0024846
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 325
• Identity: 120/325 - (36%)
• Similarity: 183/325 - (56%)
• Gaps: 33/325 - (10%)

Human    14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
            :::...:.:.||:|.|..|.|..||......|||:||:|  ...|...|...||:::::.:||:|
  Fly    18 WEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHEN 82

Human    77 IVKVYEVLGP-KGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYI 140
            ::.:.:|..| :..|   .|.:|...|:|...|:.||..::....|:::|.:..:||:|||||||
  Fly    83 VIGLLDVFHPGQPAD---SLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQILRGLKYI 144

Human   141 HSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNN 205
            |||.|:||||||:||.:: ||..|:|.||||||..:...:  ||::    |:|||:|.::|:..:
  Fly   145 HSAGVIHRDLKPSNIAVN-EDCELRILDFGLARPAESEMT--GYVA----TRWYRAPEIMLNWMH 202

Human   206 YTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL-----------LRV 259
            |.:..|:|:.|||:||:||||.||.|...:.|:.||:|.:....:|....:           |.|
  Fly   203 YNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPV 267

Human   260 MPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTS 324
            ||         :|..|.:....|..|||.|||:|..:...|:|||..|.||||..|..|.||.|:
  Fly   268 MP---------RRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTA 323

Human   325  324
              Fly   324  323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK4	NP_002738.2	STKc_MAPK4_6	14..351	CDD:143359	120/325 (37%)
		SEG motif	186..188		0/1 (0%)
		FRIEDE motif	328..333
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..413
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	499..534
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	120/325 (37%)