Protein Alignment SULF2 and Sulf1

DIOPT Version :10

• Sequence 1: NP_001373981.1
• Gene: SULF2 / 55959
• HGNCID: 20392
• Length: 871
• Species: Homo sapiens
• Sequence 2: NP_524987.1
• Gene: Sulf1 / 53437
• FlyBaseID: FBgn0040271
• Length: 1114
• Species: Drosophila melanogaster
• Alignment Length: 1079
• Identity: 388/1079 - (35%)
• Similarity: 522/1079 - (48%)
• Gaps: 284/1079 - (26%)

Human     6 LVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRD---RRNIRPNIILVLTDDQDVELGSMQVMNKT 67
            |:|.|....|||...||.:....|..| ||.||   .|..||||||:|||||||||||:..|.:|
  Fly    14 LILLLFVLNVFSKEQGSHSHKRSHSAK-RFSRDSNSARERRPNIILILTDDQDVELGSLNFMPRT 77

Human    68 RRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLN 132
            .|::..|||.|.:|:.|||||||:|||:|||.|||||..:|||:|||||.|||.||:|::|.||:
  Fly    78 LRLLRDGGAEFRHAYTTTPMCCPARSSLLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLS 142

Human   133 STGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLIT 197
            :.||||.:||||||:|||||:||||:||.||:.||::|||::..||.|.|||.||:|||..|||.
  Fly   143 NAGYRTGYFGKYLNKYNGSYIPPGWREWGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIA 207

Human   198 NDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIM 262
            |||::|.|:||:....:|||:.:|..|||||||||||||.||.|.:.|.||||::||||||.||:
  Fly   208 NDSIAFLRSSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWIL 272

Human   263 RYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGL 327
            |.|.||:|:|..|||:|..||||||.|||.::|.:||.|.|.|||||||||||:|||||:|||||
  Fly   273 RVTEPMQPVHKRFTNLLMTKRLQTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGL 337

Human   328 VKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDT 392
            :||||.|:|||:||||.:|||.::|..:...||||:|||||.||:.|:..|..|||:|||.||
  Fly   338 IKGKSFPFEFDVRVPFLIRGPGIQASKVVNEIVLNVDLAPTFLDMGGVPTPQHMDGRSILPLL-- 400

Human   393 ERPVNRFHLKKKMRV---WRDSFLVE--------------RGKLLHKRDN--------------- 425
                    |.:...|   |.||||:|              |.:|..:|.|
  Fly   401 --------LSRNRAVRDNWPDSFLIESSGRRETAEQIAESRARLQIERRNMKLANSSLLEDFLEG 457

Human   426 --------------------------------------DKVDA---------------------- 430
                                                  |.||.
  Fly   458 AGESTTIVSSSSTAATLMSSTAQQPEDGEEEVETDNEEDDVDGDGAMDSSAAALEEDDLDDAAFE 522

Human   431 ----------QEENFLP------KYQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLHKCKG 479
                      |:.|.||      |..|:...|........|.. ||||:||.: .|:.:.||||.
  Fly   523 EGDEELDQEFQQNNDLPLAPYITKMMRLNSECSDPALLKNCLP-GQKWKCVNE-EGRWRKHKCKF 585

Human   480 PMRLGGSRALSNLVPKYYGQGSEACTCDSGD------YKLSLAGRRKKLFKKKYKASYVRSRSIR 538
            .::|  ...|:.:..|.|.:.   |.|.:.|      .:...||..:  ..|:......|.|:.|
  Fly   586 HLQL--EHQLAAMPRKQYQRN---CACFTPDGVVYTKIRAPSAGLHR--VNKRTHNGPGRRRNKR 643

Human   539 SVAIEVDGRVYHVGLGDAAQP--------------RNLTKRHWPGAPED---------------- 573
                    .|:|..|.|..:.              .:.:||..|.:..:
  Fly   644 --------EVFHTELPDEMEELLDLHQVVDQLVDHTHRSKRDLPASSNETIAQVIQQIQSTLEIL 700

Human   574 ----------------QDDKDGGDFSGTGGLPDYSAANPIKVTHRRCYI-LENDTVQCDLDLYKS 621
                            ...:.|..::.:||              .||:: .....|.|...:|..
  Fly   701 ELKFNEHELHASNSSGNSYERGEKYTKSGG--------------HRCFVDATTAKVNCSNVIYDD 751

Human   622 LQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKR--------------------------PEE 660
            .:.|:..:..||..|:.|::||..|:|::..|::..                          ||
  Fly   752 EKTWRTSRTQIDMLIKLLKDKIGKLKEMKKQLRESNKQALAAGRRNDNRRRNDQSVLDSGAGPE- 815

Human   661 CDCHKISYHTQHKGRLKHR-----------GSS----------LHPFRK----------GLQEKD 694
               ..:||.|:.....:..           ||:          .|.|..          |....|
  Fly   816 ---FNMSYFTEISSTPRSNVVGQTEVFQGYGSASAFDSLEQTQSHRFTPRAECYCEPDVGENHAD 877

Human   695 KVWLLREQKRK-------KKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTS 752
            ...:.||.:||       ||.||.:|:.:....|....:.||:||||||:|||.|...|||.|.:
  Fly   878 SKEMAREARRKLKEERQRKKERKRIKKARLEKECLSEKMNCFSHDNQHWRTAPLWNDSPFCFCMN 942

Human   753 ANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSC 817
            ||||||.|:||||.|||||:|||.||.:.:::|..|.::.:|....|.....:.:|..|.:|:||
  Fly   943 ANNNTYSCLRTINGTHNFLYCEFTTGLITFYNLTIDRFETINRAAGLTPGERSHMHDALDQLKSC 1007

Human   818 KGYKQCNPRTRNMDLGLKDGGS------YEQYRQFQRRK 850
            :| :.|:.|.....|   :|||      ..|..:..:||
  Fly  1008 RG-RSCSIRRHQNHL---EGGSSAPLLPINQVHRNNKRK 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SULF2	NP_001373981.1	Catalytic domain, necessary for arylsulfatase activity. /evidence=ECO:0000269|PubMed:30788513	1..415		246/414 (59%)
		G6S	43..385	CDD:293766	219/341 (64%)
		DUF3740	529..665	CDD:463628	30/208 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..588		5/59 (8%)
		ALP_like	<750..799	CDD:474031	25/48 (52%)
Sulf1	NP_524987.1	G6S	53..408	CDD:293766	225/364 (62%)
		DUF3740	637..793	CDD:463628	28/177 (16%)
		ALP_like	<940..989	CDD:474031	25/48 (52%)