Protein Alignment SULF2 and CG7408

DIOPT Version :10

• Sequence 1: NP_001373981.1
• Gene: SULF2 / 55959
• HGNCID: 20392
• Length: 871
• Species: Homo sapiens
• Sequence 2: NP_649020.1
• Gene: CG7408 / 39991
• FlyBaseID: FBgn0036765
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 625
• Identity: 136/625 - (21%)
• Similarity: 229/625 - (36%)
• Gaps: 170/625 - (27%)

Human    43 RPNIILVLTDD---QDVEL-GSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHN 103
            :||||:::.||   .||.. ||...:......:...|....|.:| .|||.|||:::|||||..|
  Fly    34 KPNIIIIMADDLGFDDVSFRGSNNFLTPNIDALAYSGVILNNLYV-APMCTPSRAALLTGKYPIN 97

Human   104 ----HNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY---LNEYNGSYVPPGWKEWV 161
                |....|::     .|.......|.|......||||:..||:   |::.|.:....|:...:
  Fly    98 TGMQHYVIVNDQ-----PWGLPLNETTMAEIFRENGYRTSLLGKWHLGLSQRNFTPTERGFDRHL 157

Human   162 GLL------------KNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHR 214
            |.|            :.::.||....|:.:|..|  |:...|:|||:|:.:|............:
  Fly   158 GYLGAYVDYYTQSYEQQNKGYNGHDFRDSLKSTH--DHVGHYVTDLLTDAAVKEIEDHGSKNSSQ 220

Human   215 PVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNML 279
            |:.::::|.|||...|..|.                 .||..:   :.|:.......|..:..|:
  Fly   221 PLFLLLNHLAPHAANDDDPM-----------------QAPAEE---VSRFEYISNKTHRYYAAMV 265

Human   280 QRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADH-----GYH---IGQFGLVKGKSMPYE 336
            .|        :|.|:.::.:.|.....|.|:.|::.:|:     |.|   ...:.|...|:.|:|
  Fly   266 SR--------LDKSVGSVIDALARQEMLQNSIILFLSDNGGPTQGQHSTTASNYPLRGQKNSPWE 322

Human   337 FDIRVPFYVRGPNVE-AGCLNPHIVLNIDLAPTILDIAGL--DIPADMDG--------------- 383
            ..:|....:.....| .|.:....:...||.||:...||:  |....:||
  Fly   323 GALRSSAAIWSTEFERLGSVWKQQIYIGDLLPTLAAAAGISPDPALHLDGLNLWSALKYGYESVE 387

Human   384 KSILKLLDTERPVNRFHLKKKMRVWR------DSFLVERGKLLHKRDNDKVDAQEENFLPKYQRV 442
            :.|:.::|.:  |...||......|:      :..|.: |.|.| |:..:||       |:....
  Fly   388 REIVHVIDED--VAEPHLSYTRGKWKVISGTTNQGLYD-GWLGH-RETSEVD-------PRAVEY 441

Human   443 KDLCQRAEYQTACEQLG------------QKWQCVEDATGKLKLHKCKGPMRLGGSRALSNLVPK 495
            ::|.:........:|:.            .:.:|.:.|||.......:||       .|.::
  Fly   442 EELVRNTSVWLQLQQVSFGERNISELRDQSRIECPDPATGVKPCLPLEGP-------CLFDI--- 496

Human   496 YYGQGSEACTCDSGDYKLSLAGRRKKLFKKKYKASYVRSRSIRSVAIEVDGRVYHVGLGDAAQPR 560
                  ||..|:           |..|:     |.|..|    ::.:::..|:..  ....|.|.
  Fly   497 ------EADPCE-----------RSNLY-----AEYQNS----TIFLDLWSRIQQ--FAKQAHPP 533

Human   561 NLTKRHWPGAPED------------QDDKDGGDFSGTGGL 588
            |    :.||.|..            ||:|  ...|||.|:
  Fly   534 N----NKPGDPNCDPRFYHNEWTWWQDEK--ASSSGTIGV 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SULF2	NP_001373981.1	Catalytic domain, necessary for arylsulfatase activity. /evidence=ECO:0000269|PubMed:30788513	1..415		98/426 (23%)
		G6S	43..385	CDD:293766	91/390 (23%)
		DUF3740	529..665	CDD:463628	17/72 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..588		10/39 (26%)
		ALP_like	<750..799	CDD:474031
CG7408	NP_649020.1	4-S	35..423	CDD:293753	98/425 (23%)