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Protein Alignment MAPK1 and p38a

DIOPT Version :9

Sequence 1:	NP_002736.3	Gene:	MAPK1 / 5594	HGNCID:	6871	Length:	360	Species:	Homo sapiens
Sequence 2:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster

Alignment Length:	337	Identity:	159/337 - (47%)
Similarity:	223/337 - (66%)	Gaps:	12/337 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGIND 88
            |.:|..:|.||||.|..|......:.|||||:: ||:...:.:||.||:::|....|||:||:.|
  Fly    25 YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLD 89

Human    89 IIRA----PTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRD 149
            |...    .::|..:.||:|..||:.||..:::.||||:||:.:.:|||||||||||||.|:|||
  Fly    90 IFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQILRGLKYIHSAGVIHRD 154

Human   150 LKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV 214
            |||||:.:|..|:|:|.||||||..:.:      :|.|||||||||||||||...|.:::|||||
  Fly   155 LKPSNIAVNEDCELRILDFGLARPTENE------MTGYVATRWYRAPEIMLNWMHYDQTVDIWSV 213

Human   215 GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLF 279
            |||:||:::.|.:|||..::.|||.|:.:||:|..|.|..|.:..||:|:.|||......:..:|
  Fly   214 GCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVF 278

Human   280 PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLK 344
            .||:..|:|||:|||..:..|||..|:||:|||||:|.:||.|. ...|:....|..|||.:|.|
  Fly   279 KNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQ-TSPPYDHSFEDMDLPVDKWK 342

Human   345 ELIFEETARFQP 356
            |||::|...|:|
  Fly   343 ELIYKEVTNFKP 354

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.