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Protein Alignment MAPK1 and p38b

DIOPT Version :9

Sequence 1:	NP_002736.3	Gene:	MAPK1 / 5594	HGNCID:	6871	Length:	360	Species:	Homo sapiens
Sequence 2:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster

Alignment Length:	343	Identity:	163/343 - (47%)
Similarity:	235/343 - (68%)	Gaps:	12/343 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHEN 82
            :::...|.||..:|:||||.||.|.......:|||||:: ||:...:.:||.||:::|....|||
  Fly    18 WEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHEN 82

Human    83 IIGINDIIR----APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSA 143
            :||:.|:..    |.:::|.:.||:|..||:.||..:::||.||:||:.:.:|||||||||||||
  Fly    83 VIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQILRGLKYIHSA 147

Human   144 NVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 208
            .|:||||||||:.:|..|:|:|.||||||.|:.:      :|.|||||||||||||||...|.::
  Fly   148 GVIHRDLKPSNIAVNEDCELRILDFGLARPAESE------MTGYVATRWYRAPEIMLNWMHYNQT 206

Human   209 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKV 273
            .||||||||:||:|:.|.:|||..::.|||.|:.:||:|:.|.::.|.:..||||:.|||...:.
  Fly   207 ADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPRR 271

Human   274 PWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDL 338
            .:..:|..|:..|:|||:|||..:..|||..||||||||:|:|:||:||..| |.:....|.::|
  Fly   272 NFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTA-ALYDQSFEENEL 335

Human   339 PKEKLKELIFEETARFQP 356
            |.||.:|::|.|...|:|
  Fly   336 PVEKWREMVFSEVTAFKP 353

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.