DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO5C and zip

DIOPT Version :9

Sequence 1:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster


Alignment Length:1885 Identity:516/1885 - (27%)
Similarity:874/1885 - (46%) Gaps:304/1885 - (16%)


- Green bases have known domain annotations that are detailed below.


Human     7 YTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNPESLPPLRNPDILVGEND 71
            :||...||:|...:.:.:|.|.:::  ||:|...|.|.|..:  .:..:.:..: ||.......|
  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRV--MILRDDIQKM-NPPKFDKVED 135

Human    72 LTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPH 136
            :..|:.|:|.:||||::.|: .|.|||||||:..|.:||||:||||.:.|:..|.|....::.||
  Fly   136 MAELTCLNEASVLHNIKDRY-YSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPH 199

Human   137 IFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS---GSNA---------- 188
            :||:.:.||:.|..:..:|||:.:||||||||.:.:..:::.|.|:.|   ||.|          
  Fly   200 VFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINF 264

Human   189 ---------------------------------------HVEDKVLASNPITEAVGNAKTTRNDN 214
                                                   .:|.::|.:|||.||.|||||.:|||
  Fly   265 SVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDN 329

Human   215 SSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGS 279
            ||||||:..|:||....|.|||:.||||||||.:.|:::||.:||||||.|.|...:.:...|..
  Fly   330 SSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDD 394

Human   280 AEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGF-KEDFQMDVFKILAAILHLGNVQITAVGN 343
            .:.:.:. ..|:..:.||:|.||...|.|:..::|. .|||. .:|:|::|:|..|:::.....|
  Fly   395 VKSYAFL-SNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFN-SIFRIVSAVLLFGSMKFRQERN 457

Human   344 ERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAH 408
            ...:...|::..:....||||....:.:.....:|....:.|.|..|:.|...|.:|:||..|..
  Fly   458 NDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYER 522

Human   409 LFDFIVERINQALQFSGKQ-HTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQ 472
            :|.::|.|||::|..:.:| .:|||:||:.|||.|::|||||.||||.||||||.||..:|.|||
  Fly   523 MFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQ 587

Human   473 EEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVNRNPLF 536
            |||.:|.|.|..||| .|.||.||||:...||:.||||||..|..||:.::.||.:.. :.:|.|
  Fly   588 EEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKF 651

Human   537 EKPRMSNTS-FVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPF 600
            .|......: |.|.|:|.:|:|....:|.||.|.:.:.:|.:|:.|:.....|.:::..      
  Fly   652 MKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAE------ 710

Human   601 GSMITVKSAKQVIKPNSKHFRT------TVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPF 659
                .|..|:|.:.......||      ||...::..|..||:||..|.|::||||.||.||...
  Fly   711 ----IVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAG 771

Human   660 EFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQEL--SFSDKKEVCKVVLH 722
            :.|:..::.|||..||||.|||..|.:|:|..:.||..||. |:|...:  .|.|.|:.|:.::.
  Fly   772 KIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE-LLTPNVIPKGFMDGKKACEKMIQ 835

Human   723 RLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKF---LRERRAAL 784
            .|..|||.|:.|::|||||||.:|:||:.|..|:....|..|...||:|.|:.:   |::..|..
  Fly   836 ALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIR 900

Human   785 IIQ------------QYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQLIRMATITM 837
            |||            |::|....|:..:.....:|.    ::||......||.....:...|   
  Fly   901 IIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEK----LVQKEDELKQVREKLDTLAKNT--- 958

Human   838 QAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIRRFVLNIQ-LTYRVQRLQKKLEDQ 901
            |.|      .|:|::.|.|...:..|..|...|.....:|..|.:...| |...:|.|:.::|::
  Fly   959 QEY------ERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEE 1017

Human   902 NKENHGLVEKLTSLAALRAGDVEK----IQKLEAEL--EKAATHRRNYEE-----KGKRYRDAVE 955
            .       |::.:|    .|:.:|    ||.||.:|  |:||..:...|:     |.|:|    |
  Fly  1018 E-------ERVLAL----GGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKY----E 1067

Human   956 EKLA-------KLQKHNSELETQKEQIQLKLQEKTE------ELKEKMDNLTKQLFDDVQKEERQ 1007
            |.||       ||.|....||.:...:...|.|:.|      :||.|.:....:|.:.:.|:::|
  Fly  1068 EDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQ 1132

Human  1008 RMLLEKSFELKTQDYEKQIQSLKEEI--KALKDEKMQLQHLVEGEHVTSDGLKAEVARLSKQVKT 1070
            |...::|    .:..|.::..|||::  :.::.::||.|.....|.:|...|:.:....:|....
  Fly  1133 RQESDRS----KRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1193

Human  1071 ISEFEKEIELLQAQK-IDVEKHVQSQ----KREMREKMSEITKQLLESYDI----EDVRSRLSVE 1126
            .::.|.|.:|.:.|: ::.||..:::    :|::.|::..:..:||:|.|.    :::||:    
  Fly  1194 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSK---- 1254

Human  1127 DLEHLNEDGELWFAYEGLKKATRVLESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQK------ 1185
                  .:.||....:.|::.|...|......:..:.:|:.::|.::.:|.:....|:|      
  Fly  1255 ------REQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLE 1313

Human  1186 -----LFREENDINESIRHEVTRLTSENMMIPDFKQQISELEKQKQDLEIRLNEQAEKMKGKLEE 1245
                 |..|...:|.|.:....|.......|.:.:.:::|:|:.:.:|:    |:..|::.:.|.
  Fly  1314 AENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQ----EKCTKLQQEAEN 1374

Human  1246 LSNQLHRSQ--------EEEGTQRKALEAQN--EIHTKEKEKLIDKIQEMQEASDHLKKQFETES 1300
            ::|||..::        .....:.:..|||.  |..|::|..|..|:::::...:.|::|.|.:.
  Fly  1375 ITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDD 1439

Human  1301 EVKCNFRQEASRLTLENRDLEEELDMKDRVIKKLQDQVKTLSKTIG----------KANDVHSSS 1355
            |.|.|:.::.:.:|.:.::::::.:....:.|:|::..|.|:|.|.          ..||....|
  Fly  1440 EAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKS 1504

Human  1356 GPKEYLGMLQYKRED---EAKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANMLK 1417
            ..|     :|.:.||   |.:..:..:|:|:.:....:.|......|.....:..|:.......|
  Fly  1505 KKK-----IQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREK 1564

Human  1418 SLMNSTINGIKQVVKEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCL----- 1477
            .....:::.......:.:||.|.....|.|.   |:.|....|..:...|.. ::.|..|     
  Fly  1565 ETKVLSVSRELDEAFDKIEDLENKRKTLQNE---LDDLANTQGTADKNVHEL-EKAKRALESQLA 1625

Human  1478 ----NNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSS 1538
                .|.:|.:..|:..|..:|        :|.|:|.:  ....|.:.|....|.:    .||  
  Fly  1626 ELKAQNEELEDDLQLTEDAKLR--------LEVNMQAL--RSQFERDLLAKEEGAE----EKR-- 1674

Human  1539 SIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKG 1603
                      ..:::||         ..|:.||..:..::.     |...:...|..|:......
  Fly  1675 ----------RGLVKQL---------RDLETELDEERKQRT-----AAVASKKKLEGDLKEIETT 1715

Human  1604 MQIRCNISYLEEWLKD-KNLQNSL------------AKETLEPLSQ---------AAWLLQVKKT 1646
            |::...:.  |:.||. |.||..:            |||.|:.||:         .|.:||:  |
  Fly  1716 MEMHNKVK--EDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQL--T 1776

Human  1647 TDSDAKEIYERCTSLS----AVQIIKILNSYTPIDDFEKRVTPSFVRKVQALLNSREDSSQLMLD 1707
            .|..:.|...|.....    |.:|....|..:.:.| |||...:.:..::..|...:.:|:::||
  Fly  1777 EDLASSERARRAAETERDELAEEIANNANKGSLMID-EKRRLEARIATLEEELEEEQSNSEVLLD 1840

Human  1708  1707
              Fly  1841  1840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832 11/35 (31%)
MYSc 62..752 CDD:214580 281/753 (37%)
MYSc_Myo5 81..741 CDD:276831 268/723 (37%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654 12/21 (57%)
IQ 810..828 CDD:197470 4/17 (24%)
COG1340 890..1150 CDD:224259 68/294 (23%)
P-loop_NTPase <910..>1163 CDD:304359 66/287 (23%)
GBP_C <927..1030 CDD:303769 32/122 (26%)
coiled coil 997..1010 CDD:293879 4/12 (33%)
coiled coil 1019..1030 CDD:293879 1/10 (10%)
Rab5-bind 1020..1345 CDD:286404 70/356 (20%)
DUF3585 1160..1326 CDD:304905 35/186 (19%)
Myo5c_CBD 1369..1736 CDD:271260 72/377 (19%)
zipNP_523860.2 Myosin_N 80..117 CDD:280832 11/40 (28%)
Myosin_head 133..854 CDD:278492 272/735 (37%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 268/723 (37%)
Myosin_tail_1 931..2011 CDD:279860 206/1010 (20%)
Prefoldin 1431..1515 CDD:298833 19/88 (22%)
FAM76 <1847..1926 CDD:292665
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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