DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYO5C and Mhc

DIOPT Version :9

Sequence 1:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1511 Identity:449/1511 - (29%)
Similarity:731/1511 - (48%) Gaps:224/1511 - (14%)


- Green bases have known domain annotations that are detailed below.


Human     7 YTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNPESLPPLRNPDILVGEND 71
            |......||||.:|.:...||..  ..|| ::.:.|:.|...|  :..|.:..: ||.......|
  Fly    32 YDSKKSCWIPDEKEGYLLGEIKA--TKGD-IVSVGLQGGEVRD--IKSEKVEKV-NPPKFEKIED 90

Human    72 LTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPH 136
            :..::.|:.|.||||||.|: .:||||||||:..||:||||:.|:|.:.....|.|:...::.||
  Fly    91 MADMTVLNTPCVLHNLRQRY-YAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPH 154

Human   137 IFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS-------GSNAHVEDKV 194
            |||:::.||..|..|:.|||::::||||||||.:.:..:.|||||..|       .|...:||:|
  Fly   155 IFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQV 219

Human   195 LASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHI 259
            :.:||:.||.|||||.||||||||||:..|.|....::.||::.||||||:||:.|...||:|||
  Fly   220 VQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHI 284

Human   260 FYQLCASAQQSEFKHLKLGSAEEFNYTRMG-GNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDV 323
            |||: .|......|.:.|.:...::|..:. |...:..::|..|...|.:.|.:|||.:..:.||
  Fly   285 FYQI-MSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDV 348

Human   324 FKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKP 388
            ::|.||::|:|.::....|.|..:..:.:.......:|.|.::..:.:.|...:|...:|.|.:.
  Fly   349 YRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQG 413

Human   389 MTRPQAVNARDALAKKIYAHLFDFIVERINQALQFSGKQHTFIGVLDIYGFETFDVNSFEQFCIN 453
            ....|..|:..||.|.::..||.::|::.|:.|....|:..|||||||.|||.|:.|.|||.|||
  Fly   414 RNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCIN 478

Human   454 YANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILELLDEECLLPHGT 517
            :.||||||.||.|:|.||||||.:|.|.|..||| .|....|||||..||||.:|:||.:.|..|
  Fly   479 FTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKAT 543

Human   518 DENWLQKLYNNFVNRNPLFEKPR-----MSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEI 577
            |:.:.:||.|..:.::..|:||:     .....|.|.|:|..|.|...|:||||:|.:.|.:|:.
  Fly   544 DQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQ 608

Human   578 LRASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNAT 642
            .:.|:..|....|.::.      |.....:.||.........| .||.|.::..|..||.||.:|
  Fly   609 FKKSQNKLLIEIFADHA------GQSGGGEQAKGGRGKKGGGF-ATVSSAYKEQLNSLMTTLRST 666

Human   643 TPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQE 707
            .||:||||.||:.|.|...|:..::.||...||||.|||..:.:|:|..|.:|..||.|:..|..
  Fly   667 QPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL 731

Human   708 LSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQ 772
            ......|:..::::..:....:||:.|.||:|||||.:..:|:.|.::|.:....:|...||:|.
  Fly   732 QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLS 796

Human   773 RKKF--LRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYL------------- 822
            ||.|  |:|:|                     ||||      ::|::.|.||             
  Fly   797 RKGFKKLQEQR---------------------VALK------VVQRNLRKYLQLRTWPWYKLWQK 834

Human   823 VRSLYQLIR----MATITMQAYSRGFL--ARRRYRKMLE-------EHKAVILQKYARAWLARRR 874
            |:.|..:.|    :|.:..:|.....|  |..:.||.||       ..|..:|...:....|.:.
  Fly   835 VKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQD 899

Human   875 FQSIRRFVLNIQLTYRVQRLQKKLEDQNKENHGLVEKLTSLAALR--------------AGDVEK 925
            :|.     .|.:||.:...|:.:|.|       :.|:||.....|              :|..:.
  Fly   900 YQE-----RNAKLTAQKNDLENQLRD-------IQERLTQEEDARNQLFQQKKKADQEISGLKKD 952

Human   926 IQKLEAELEKAATHRRNYEEKGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKM 990
            |:.||..::||...:...:.:.:...|.:..:...:.|.|.|.:.|.|..| |..|:.:..::|:
  Fly   953 IEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQ-KTGEELQAAEDKI 1016

Human   991 DNLTK----------QLFDDVQKEERQRMLLEKS-----FELK-TQ----DYEKQIQSLKEEIKA 1035
            ::|.|          :|.|.:::|::.|..:|||     .:|| ||    |.|:..:.|::.|:.
  Fly  1017 NHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQR 1081

Human  1036 LKDEKMQLQHLVEGEHVTSDGLKAEVARLSKQVK----TISEFEKEIELLQAQKIDVEKHVQSQK 1096
            ...|...:...:|.|.|.       |.:..:|:|    .|.|.|:|:|..:..:...||    |:
  Fly  1082 KDKELSSITAKLEDEQVV-------VLKHQRQIKELQARIEELEEEVEAERQARAKAEK----QR 1135

Human  1097 REMREKMSEITKQLLE-----SYDIEDVRSR---LSV--EDLEHLNEDGELWFAYEGLKK----- 1146
            .::..::.|:.::|.|     |..||..:.|   ||.  .|||..|...|...|  .|:|     
  Fly  1136 ADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLA--NLRKKHNDA 1198

Human  1147 ----ATRV-----LESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQKLFREENDINESIRHEVT 1202
                |.:|     |::..:.:|:.|..::..|...|.|::.|....:|:.::   :..::....:
  Fly  1199 VAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQ---LQHTLNEVQS 1260

Human  1203 RLTSENMMIPDFKQQISELEKQKQDLEIRLNEQAEKMKGKLEELSNQLHRSQEEEGTQRKALEAQ 1267
            :|...|..:.||.....:|..:..|| :|..|:||....:|.::...|  :.:.|.|:|.|.|  
  Fly  1261 KLDETNRTLNDFDASKKKLSIENSDL-LRQLEEAESQVSQLSKIKISL--TTQLEDTKRLADE-- 1320

Human  1268 NEIHTKEKEKLIDKIQEMQEASDHLKKQFETESEVKCNFRQEASRLTLE---------------N 1317
               .::|:..|:.|.:.::...|:|::|.|.|:|.|.:.:::.|:...|               :
  Fly  1321 ---ESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARS 1382

Human  1318 RDLE-----------------EELDMK----DRVIKKLQDQVKTLSKTIGKANDVHSSSGPKE-- 1359
            .:||                 |.|:.|    ::..::|..:|:.|...:.:||.:.:::..|:  
  Fly  1383 EELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKA 1447

Human  1360 ---YLGMLQYKREDEA 1372
               .:|..:.|.:|.|
  Fly  1448 FDKIIGEWKLKVDDLA 1463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832 11/35 (31%)
MYSc 62..752 CDD:214580 270/703 (38%)
MYSc_Myo5 81..741 CDD:276831 261/673 (39%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654 13/21 (62%)
IQ 810..828 CDD:197470 6/30 (20%)
COG1340 890..1150 CDD:224259 73/316 (23%)
P-loop_NTPase <910..>1163 CDD:304359 73/314 (23%)
GBP_C <927..1030 CDD:303769 29/122 (24%)
coiled coil 997..1010 CDD:293879 4/12 (33%)
coiled coil 1019..1030 CDD:293879 4/14 (29%)
Rab5-bind 1020..1345 CDD:286404 85/392 (22%)
DUF3585 1160..1326 CDD:304905 40/197 (20%)
Myo5c_CBD 1369..1736 CDD:271260 2/4 (50%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 12/41 (29%)
MYSc 81..777 CDD:214580 270/704 (38%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 261/673 (39%)
Myosin_tail_1 842..1897 CDD:279860 143/659 (22%)
V_Alix_like 1557..1877 CDD:187408
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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