DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO5C and hum-2

DIOPT Version :9

Sequence 1:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens
Sequence 2:NP_001317742.1 Gene:hum-2 / 179321 WormBaseID:WBGene00002036 Length:1811 Species:Caenorhabditis elegans


Alignment Length:1904 Identity:663/1904 - (34%)
Similarity:981/1904 - (51%) Gaps:289/1904 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    12 RVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNP-ESLPPLRNPDILVGENDLTAL 75
            |:|...|..||..|.:.:|.....:.:|:.|||.||::|::.. :.||.||||..|||::|||.|
 Worm    23 RIWHRHPTLVWIGATLEEDITFQTRNVRIRLEDDTEVEYAIKSLDQLPFLRNPAFLVGKDDLTLL 87

Human    76 SYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLP-IYGDAIIHAY--SGQNMGDMDPHI 137
            ||||||||||||::||.:...||||.||:|||:|||.... |||:.||..|  :|::..:|||||
 Worm    88 SYLHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEEIIQVYRGAGKSAREMDPHI 152

Human   138 FAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATV----SKSGSNAHVEDKVLASN 198
            |||||||:..|....::|||||||||||||||||::.|||.|:|    :::|....:|.:|||||
 Worm   153 FAVAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRYLASVAASKTRNGGTTSIEARVLASN 217

Human   199 PITEAVGNAKTTRNDNSSRFGKYTEISFDEQ-NQIIGANMSTYLLEKSRVVFQSENERNYHIFYQ 262
            ||.|::|||||.||||||||||:.:|:|.|: .:|:||.|.||||||||:|||:..|||||||||
 Worm   218 PIMESIGNAKTIRNDNSSRFGKFIQINFCERGRRIVGAEMKTYLLEKSRLVFQAPGERNYHIFYQ 282

Human   263 LCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVFKIL 327
            |||:......|.|.||..|.::|...||::.|.||:|:|:.....|...||||.|....|||::|
 Worm   283 LCAARNHQVLKDLHLGPCESYSYLTQGGDSRIPGVDDKADFEALLKALQLLGFDEKQMSDVFRLL 347

Human   328 AAILHLGNVQI-TAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTR 391
            |.:|.||||.. ...|:...|.|......::..|...:....:..||..|:|...:|.|.||:|:
 Worm   348 AGLLLLGNVHFENGEGSSAVSASSCQEISRLCREFWKISESDLRIWLTRREIRAVNEIVTKPLTK 412

Human   392 PQAVNARDALAKKIYAHLFDFIVERINQALQFSGK---------QHTFIGVLDIYGFETFDVNSF 447
            .:||.:||||.|.:|:|||.::|::||:||....|         ...||||||||||||||||||
 Worm   413 NEAVRSRDALTKMLYSHLFGWLVDKINEALNEKDKLDGTNQKKRPDRFIGVLDIYGFETFDVNSF 477

Human   448 EQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEECL 512
            |||.|||||||||||||.||||||||||::|:|.|..:||:||||.|||||..:|::.||||:|.
 Worm   478 EQFSINYANEKLQQQFNQHVFKLEQEEYIREEIEWVRVDFHDNQPAIDLIEGPVGMINLLDEQCK 542

Human   513 LPHGTDENWLQKLYNNF-VNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVE 576
            ..:|:|.:||.:|.|:. :.|||....|::.:..|:::|||..|.|..:||:|||||.:.:.|::
 Worm   543 RLNGSDADWLSQLQNSTELKRNPQLAFPKVRSNDFIVRHFAADVTYSTDGFVEKNRDAIGEQLLD 607

Human   577 ILRASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNA 641
            ::.||||.......  ..|.|:      :|.|:.....|..:..:.||.|:||.||..||..|.:
 Worm   608 VVVASKFPFIRTVI--GSTAPT------SVSSSSSSSTPGKRTIKKTVASQFRDSLKELMSVLCS 664

Human   642 TTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQ 706
            |.|||||||||||.|:.|:|:.||.:|||||||||||:||||..:|||:.|.||..||.::.||:
 Worm   665 TRPHYVRCIKPNDSKISFDFEPKRAIQQLRACGVLETVRISAAGFPSRYPYEEFARRYRVIYTKE 729

Human   707 ELSFSDK-KEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGW 770
            ...:.|| |:..::...:.::: .:|..||||||.|.||||.||::|||.|..:..::||..:|:
 Worm   730 AALWRDKPKQFAELACQQCLEE-GKYAVGKTKIFLRTGQVAVLERVRLDTLAAAATVIQKMWKGF 793

Human   771 LQRKKFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQLIR---- 831
            |.|:|:...||:.||:|...:.....|:   ...|:...|.|::|...||||.|..|:.||    
 Worm   794 LARRKYETMRRSLLIVQASLKAFLAFRR---IKYLQMHRAVIVMQSAVRGYLERRKYEQIRDSII 855

Human   832 ---------------------MATITMQAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRF 875
                                 .:.||:||..||:||||  .::....|.|::|...|.|||:||.
 Worm   856 GIQAMFKANRVRRYVEKLRYEKSAITIQAAWRGYLARR--EQIANRKKVVMVQCAVRKWLAKRRL 918

Human   876 QSIR---RFV-----LNIQLTYRVQRLQKKLEDQNKENHGLVEKLTSL--------AALRAGDVE 924
            :.::   |.|     ||..|..::..||.:|:..|.......||..:.        |.|...:.|
 Worm   919 RELKIEARSVGHLQKLNTGLENKIIELQMRLDIANARTKEEAEKFATASKNLQKTKADLAMMEAE 983

Human   925 KIQKLEA---------ELEKAATHRRNYEEKGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQ 980
            ::..|||         |:|:..|.....|.:    |..:|.|:.:||....:.:.|.|..| .:.
 Worm   984 RLTLLEARNRVEVLQEEVERLETECDLKEAQ----RGGMETKMVELQSRLDQFQMQSESGQ-TIV 1043

Human   981 EKTEEL-KEKMDNLTKQLFDDVQKEERQRMLLEKSFELKTQDYEKQIQSLKEEIKALKDEKMQLQ 1044
            |.||:| |.|.|.:   |:|    ||||||....:.|...::      :|..|:.|::::.|:..
 Worm  1044 ELTEQLEKAKADRV---LWD----EERQRMEAALNTERSARN------ALDAEMAAMREQLMKNV 1095

Human  1045 HLVE---------------------------------------GEHVTSDG----LKAEVARLSK 1066
            .|.|                                       |.|.||.|    |...:|...:
 Worm  1096 DLFESSTFQKRPSQKKNRDDDSCSRTTSNLSQLTGSFTAETINGVHSTSRGSPEVLLDNMASTFE 1160

Human  1067 QVKTISEFEKEIELLQAQKIDVEKHVQSQKREMREKMSEITKQLLESYDIEDVRSRLSVEDLEHL 1131
            |::.|::..:..|           |.|.:...|:..:...|  |:|:.|     .:.|::..|.:
 Worm  1161 QLRMINDLRQRNE-----------HCQRETERMKAIIEAST--LIETLD-----KKTSLKAFESI 1207

Human  1132 NEDGELWFAYEGLKKATRVLESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQKLFREENDINES 1196
            .. |||..||..||                  .::|.|      :|.|......:|....:.||.
 Worm  1208 RV-GELEGAYNRLK------------------NDMERL------VSGENGATHSVFERIMEENER 1247

Human  1197 IRHEVTRLTSENMMIPDFKQQI----------------------SELEKQKQDLE--IRLNEQAE 1237
            :|.|...|.|  |:...|::|.                      ||......|||  :.:..|..
 Worm  1248 LREEAVELRS--MLSSHFEKQSVAGSSGYRRSPRPDSGHCSGADSEDGSSGADLEEDLCIERQCR 1310

Human  1238 KMKGKLEELSNQL-HRSQEEEGTQRKALEAQNEIHTKEKEKLIDK------------IQEMQEAS 1289
            .:|...|.|:..| :::.|.|..|::...::::...:..:..:|:            .|:..:.:
 Worm  1311 HLKNLAENLTKMLTNQNLEIERLQQQLRFSESQTVFRPSDCSLDEAVRGAHKQTQLLAQQNMDLN 1375

Human  1290 DHLKKQFETESEVKCNFRQEASRLTLENRDLEEELDMKDRVIKKLQDQVKTLSKTIGKANDVHSS 1354
            |.|.:|.|..:|.:...|..:..|.|||...||.:.:                :...|.:..|| 
 Worm  1376 DKLTRQSEELAEARAQLRGYSGPLGLENASDEEIIRL----------------EAFEKGSIKHS- 1423

Human  1355 SGPKEYLGMLQ-YKREDEAKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANMLKS 1418
                   |.|: |...:.|::|   :.:|||. :...:...|||::|....|..|...|...|..
 Worm  1424 -------GFLEVYNVPEFARII---VCELKPT-LARLLTKNLPAYLLVAAFRNHDEKRDETALTG 1477

Human  1419 LMNSTINGIKQVV-KEHLEDFEMLSFWLSNTCHFLNCLKQYSGEE---EFMKHNSPQQNKNCLNN 1479
            |.:|....:|..: :.|  |.::||.||.|.....|.|:|||||:   |:...|:..||......
 Worm  1478 LFSSVHLVLKDTISRSH--DLDLLSLWLVNLWRLFNLLRQYSGEDSQPEWHVANTETQNSYRFKA 1540

Human  1480 FDLSEYRQILSDVAIRIYHQFIIIMEKNIQ----PIIVPGMLEYESLQGISGLKPTG--FRKRSS 1538
            :|::..|..|.   :||...:..:|:|.|:    |.||||:|::||   .|.|...|  .|.|:|
 Worm  1541 YDVAPIRDQLK---LRIEECYTSLMKKAIEHVLSPKIVPGILQHES---SSDLMTAGQERRDRNS 1599

Human  1539 SIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKG 1603
            ...::...::..:||.:...:|.:...|.|..:|:|.:.|:...:.|:.||.:..|:::|:..|.
 Worm  1600 GSVESQRKSLDDLLQFMEIVHTKLTTYGGDDIVVKQVIGQMARWMCALALNYMMFRRELCNFEKA 1664

Human  1604 MQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIK 1668
            :||:.|::.::.||..|.|.:  .::..|||.||..|||.:|...:......|..:.|...|::.
 Worm  1665 IQIKHNVTQIQNWLNAKGLSD--CRDHFEPLVQACHLLQSRKDPSNLDTLCGEMTSRLKPRQVVA 1727

Human  1669 ILNSYTPIDDFEKRVTPSFVRKVQALLNSR--------EDSSQLMLDTKYL--FQVTFPFTPSPH 1723
            ||..|.|.|:.|..::|.|:.::|..||.|        ||..:|::...||  |. |.||:.|..
 Worm  1728 ILQHYDPSDEMEDGLSPEFLVQIQKKLNERAIANNDPIEDKDKLIMLGTYLPPFD-TQPFSYSDF 1791

Human  1724 ALEMIQIPSSFKLGFLNRL 1742
            .||.:.:||...:..:.||
 Worm  1792 PLETLSLPSCLHMQSVCRL 1810

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832 12/35 (34%)
MYSc 62..752 CDD:214580 357/709 (50%)
MYSc_Myo5 81..741 CDD:276831 336/679 (49%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654 14/21 (67%)
IQ 810..828 CDD:197470 8/17 (47%)
COG1340 890..1150 CDD:224259 72/320 (23%)
P-loop_NTPase <910..>1163 CDD:304359 68/313 (22%)
GBP_C <927..1030 CDD:303769 31/112 (28%)
coiled coil 997..1010 CDD:293879 7/12 (58%)
coiled coil 1019..1030 CDD:293879 0/10 (0%)
Rab5-bind 1020..1345 CDD:286404 73/404 (18%)
DUF3585 1160..1326 CDD:304905 41/202 (20%)
Myo5c_CBD 1369..1736 CDD:271260 115/386 (30%)
hum-2NP_001317742.1 MYSc_Myo5 93..764 CDD:276831 336/679 (49%)
IQ 779..799 CDD:197470 6/19 (32%)
IQ 826..847 CDD:197470 8/20 (40%)
CCDC158 <864..1473 CDD:318193 155/701 (22%)
Myo5_CBD 1429..1803 CDD:271254 116/388 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 661 1.000 Domainoid score I76
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1036 1.000 Inparanoid score I140
Isobase 1 0.950 - 0 Normalized mean entropy S1278
OMA 1 1.010 - - QHG52542
OrthoDB 1 1.010 - - D311886at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X244
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.930

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