Protein Alignment PRKG2 and for

DIOPT Version :10

• Sequence 1: NP_006250.1
• Gene: PRKG2 / 5593
• HGNCID: 9416
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 754
• Identity: 348/754 - (46%)
• Similarity: 477/754 - (63%)
• Gaps: 86/754 - (11%)

Human    29 KVTELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSP 93
            |:.|::|.|:.||.||.|.:.|                            |:|.|.|.....||.
  Fly   401 KIQEMQRALQFKDNEIAELKSH----------------------------LDKFQSVFPFSRGSA 437

Human    94 L----------------QASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEF 142
            .                ..|.........||:    ..:.:|....|:||||.:.:..|.:  ..
  Fly   438 AGCAGTGGASGSGAGGSGGSGPGTATGATRKS----GQNFQRQRALGISAEPQSESSLLLE--HV 496

Human   143 SFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFV 207
            ||.|  ..||...::||..|:..|.|:|.||..||:::|:|||...|...:.|||:|:.|:.::|
  Fly   497 SFPK--YDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYV 559

Human   208 LAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQA 272
            :.:||:||.:..|.||::......|||||||||.|||::.|||....||::|:.||.||.||...
  Fly   560 MEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLI 624

Human   273 RDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQST 337
            |..:|.:||:||.:.|:|.||.|.||.|.||..:|.:||||:|:|..|.||||::||||:||...
  Fly   625 RQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQ 689

Human   338 EGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEEND-VACLVIDRETFNQTVGTFEELQ-KY 400
            :...:.:.|:.|.||::||||||..||:|:||||.|..| |:|||||||||||.:...:|:: :|
  Fly   690 QDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRY 754

Human   401 LEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFG 465
                      |||....:|.::.       ....|.|.:             |.:||||||||||
  Fly   755 ----------DDEGAMERRKINE-------EFRDINLTD-------------LRVIATLGVGGFG 789

Human   466 RVELVKVKNENV-AFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYML 529
            |||||:...::. :||:|.::|..||:|:||:|:.|||.|:.|....|||||::||||.||:|||
  Fly   790 RVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYML 854

Human   530 LEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVD 594
            :|:|||||||:||||:|:||:.|::|..|||.|||||||...|||||||||||:|:..||:||||
  Fly   855 MESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVD 919

Human   595 FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTY 659
            ||||||:.:|:|||||||||||||||||||:|||.|.|:||||:|::|||||.|||:|.|.|.||
  Fly   920 FGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTY 984

Human   660 NLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSL 724
            |:|||||:.::|||.|||...:||::|||.||.||||..:.||::|:||:|.:||.|.||:..:|
  Fly   985 NIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTL 1049

Human   725 PSPLQRELKGPIDHSYFDKYPPE-KGMPPDELSGWDKDF 762
            ..|::..:|..:|.:.||.|||: :|.|||:::||||||
  Fly  1050 EPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG2	NP_006250.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..138		7/20 (35%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000305|PubMed:26769964	168..283		52/114 (46%)
		CAP_ED	168..277	CDD:237999	49/108 (45%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000305|PubMed:26769964	286..416		64/131 (49%)
		CAP_ED	286..401	CDD:237999	60/116 (52%)
		STKc_cGK	459..718	CDD:270724	167/259 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	740..762		13/22 (59%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	14/58 (24%)
		CAP_ED	520..629	CDD:237999	49/108 (45%)
		CAP_ED	638..754	CDD:237999	60/115 (52%)
		STKc_cGK	783..1043	CDD:270724	167/259 (64%)