DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRKG2 and wts

DIOPT Version :10

Sequence 1:NP_006250.1 Gene:PRKG2 / 5593 HGNCID:9416 Length:762 Species:Homo sapiens
Sequence 2:NP_733403.1 Gene:wts / 43651 FlyBaseID:FBgn0011739 Length:1105 Species:Drosophila melanogaster


Alignment Length:418 Identity:127/418 - (30%)
Similarity:208/418 - (49%) Gaps:68/418 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   393 TFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIA 457
            |:.:.|  ||..:..:...|:.:...|.|.|.|.|..:.|:..::        ..|.|..|:   
  Fly   672 TYRKNQ--LEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKM--------DKSMFVKLK--- 723

Human   458 TLGVGGFGRVELV-KVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFK 521
            .:|||.||.|.|| |:...|..:|||.:||..::...|..||.:|:.||.|..:.::||||.:|:
  Fly   724 PIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQ 788

Human   522 DNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDA 586
            |...:|.:::...||:|.|:|...|.|:|..::|.:|.||.|.|.:|::|.|:||:||:|:::|.
  Fly   789 DKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDR 853

Human   587 EGYLKLVDFG------------FAKKIGS-----GQKTW-------------------------- 608
            :|::||.|||            :.::.|:     ..:.|                          
  Fly   854 DGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLA 918

Human   609 -TFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFP 672
             :..|||.|:||||:...|:....|:||:|:::||:|.|.|||.....:.|...::...:.:..|
  Fly   919 HSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIP 983

Human   673 --RKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGP 735
              .:::|...||||||| .:..:|||   ..::::|.|.:..|.::..:  |...:|...|:|.|
  Fly   984 PQAELSREATDLIRRLC-ASADKRLG---KSVDEVKSHDFFKGIDFADM--RKQKAPYIPEIKHP 1042

Human   736 IDHSYFDKYPPEKGMPPDEL--SGWDKD 761
            .|.|.||...|||....|..  ||.|.|
  Fly  1043 TDTSNFDPVDPEKLRSNDSTMSSGDDVD 1070

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRKG2NP_006250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..138
cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000305|PubMed:26769964 168..283
CAP_ED 168..277 CDD:237999
cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000305|PubMed:26769964 286..416 5/22 (23%)
CAP_ED 286..401 CDD:237999 2/7 (29%)
STKc_cGK 459..718 CDD:270724 96/305 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 740..762 10/24 (42%)
wtsNP_733403.1 MobB_LATS1 644..718 CDD:439273 11/55 (20%)
STKc_LATS 717..1078 CDD:270749 116/363 (32%)
Blue background indicates that the domain is not in the aligned region.

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