DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PRKG2 and Akt

DIOPT Version :10

Sequence 1:NP_006250.1 Gene:PRKG2 / 5593 HGNCID:9416 Length:762 Species:Homo sapiens
Sequence 2:NP_732113.3 Gene:Akt / 41957 FlyBaseID:FBgn0010379 Length:611 Species:Drosophila melanogaster


Alignment Length:694 Identity:174/694 - (25%)
Similarity:301/694 - (43%) Gaps:170/694 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   101 VPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDL-----------NKPP------EFSFEKAR 148
            :|..:.|: |.:|:.....|:.:.:...|||...::           |..|      :||::::.
  Fly     4 LPFVLQRR-STVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSGSAEKFSWQQSW 67

Human   149 VRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQG---EPGNHI----- 205
            ..:.|:.....:..::.|.......|....       |....:.:.::|:|   :.|.||     
  Fly    68 PSRTSAAPTHDSGTMSINTTFDLSSPSVTS-------GHALTEQTQVVKEGWLMKRGEHIKNWRQ 125

Human   206 --FVL-AEGRLEVFQGEKLLS-SIPMWTTFGELAILYNCT-RTASVKAITNVK--TWALDREVFQ 263
              ||| ::|||..::.:...| |.|  :.|    :|.|.| |...:..:...|  |:.:....:.
  Fly   126 RYFVLHSDGRLMGYRSKPADSASTP--SDF----LLNNFTVRGCQIMTVDRPKPFTFIIRGLQWT 184

Human   264 NIMRRT----AQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFF 324
            .::.||    ::...:|:...:|:||          :::||.                       
  Fly   185 TVIERTFAVESELERQQWTEAIRNVS----------SRLIDV----------------------- 216

Human   325 ILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQ 389
                |:|.:|.|    :|..:                 .||..|.|..:|..        |.|: 
  Fly   217 ----GEVAMTPS----EQTDM-----------------TDVDMATIAEDELS--------EQFS- 247

Human   390 TVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLE 454
                       ::|...|.:.                .|.::||                  |.|
  Fly   248 -----------VQGTTCNSSG----------------VKKVTLE------------------NFE 267

Human   455 IIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRT 519
            .:..||.|.||:|.|.:.|.....:|:|.::|:.|:...:..|..:|.|:|:....||::.|..:
  Fly   268 FLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYS 332

Human   520 FKDNKYVYMLLEACLGGEL-WSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLI 583
            |:.|..:..:::...|||| |.:..:| .|.|..::|..|.:..|..|||..||||||||.|||:
  Fly   333 FQTNDRLCFVMQYVNGGELFWHLSHER-IFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLL 396

Human   584 LDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGN 647
            ||.:|::|:.|||..|: |..|:.|.||||||||:||||:.:..:..:||:|..|:::||::.|.
  Fly   397 LDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGR 461

Human   648 PPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLN 712
            .||...|..:.:.|||  :|::.|||.||...::|:..|..::|.:|||..|:.:.:|:.|.:..
  Fly   462 LPFYNRDHDVLFTLIL--VEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFA 524

Human   713 GFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGM---PPD 753
            ..||..|..:.:|.|.:.::....|..||||....:.:   |||
  Fly   525 SINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPD 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRKG2NP_006250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..138 4/31 (13%)
cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000305|PubMed:26769964 168..283 26/133 (20%)
CAP_ED 168..277 CDD:237999 25/127 (20%)
cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000305|PubMed:26769964 286..416 16/129 (12%)
CAP_ED 286..401 CDD:237999 14/114 (12%)
STKc_cGK 459..718 CDD:270724 99/260 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 740..762 7/17 (41%)
AktNP_732113.3 PH_PKB 105..214 CDD:269947 27/124 (22%)
STKc_PKB 270..590 CDD:270723 110/302 (36%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.