DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRKG2 and S6k

DIOPT Version :10

Sequence 1:NP_006250.1 Gene:PRKG2 / 5593 HGNCID:9416 Length:762 Species:Homo sapiens
Sequence 2:NP_523941.2 Gene:S6k / 38654 FlyBaseID:FBgn0283472 Length:490 Species:Drosophila melanogaster


Alignment Length:392 Identity:142/392 - (36%)
Similarity:211/392 - (53%) Gaps:51/392 - (13%)


- Green bases have known domain annotations that are detailed below.


Human   357 EKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSM 421
            :||..|||.|     .|.:||                  :|:..|   ..||::|.|.:      
  Fly    23 DKARDSDDDR-----IELDDV------------------DLEPEL---CINLHQDTEGQ------ 55

Human   422 SNWKLSKALSLEMIQL-KEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKV---KNENVAFAMK 482
                       |.||| :|.|.........::.|:...||.||:|:|..|:.   ::.|..||||
  Fly    56 -----------ETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMK 109

Human   483 CIRKKHIV-DTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRG 546
            .::|..|| :.|...|..:|:.|||.:..||||:|...|:.:..:|::||...||||:..|...|
  Fly   110 VLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREG 174

Human   547 SFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTF 610
            .|.|.|:.|.::.:..|..:||:||||||||||||::|||:|::||.|||..|: |..|..|.||
  Fly   175 IFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTF 239

Human   611 CGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKI 675
            |||.||:|||::...||..:||:||||.|::::|||.|||:..::..|...|||.  |::.|..:
  Fly   240 CGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKA--KLNLPAYL 302

Human   676 TRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY 740
            |....||:|||.::...:|||:.......::.|.:....||:.:.||.|..|::..|:...|.|.
  Fly   303 TPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQ 367

Human   741 FD 742
            ||
  Fly   368 FD 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRKG2NP_006250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..138
cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000305|PubMed:26769964 168..283
CAP_ED 168..277 CDD:237999
cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000305|PubMed:26769964 286..416 15/58 (26%)
CAP_ED 286..401 CDD:237999 10/43 (23%)
STKc_cGK 459..718 CDD:270724 111/263 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 740..762 2/3 (67%)
S6kNP_523941.2 STKc_p70S6K 81..402 CDD:270736 120/291 (41%)
Blue background indicates that the domain is not in the aligned region.

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