Protein Alignment PRKG2 and CG4839

DIOPT Version :10

• Sequence 1: NP_006250.1
• Gene: PRKG2 / 5593
• HGNCID: 9416
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Alignment Length: 770
• Identity: 300/770 - (38%)
• Similarity: 436/770 - (56%)
• Gaps: 79/770 - (10%)

Human    18 SGNLTTDALRNKVTELERELRRKDAEIQE-----------------REYHLKEL----REQLSKQ 61
            |.|::.:.|....|:.:|  ||:.:.:.:                 ...||::.    |:|..||
  Fly   288 SSNVSLNYLAKSQTDSQR--RRRVSTMPDINIPPAPPLPPELLVPGTPLHLRKKRSMERQQQQKQ 350

Human    62 TVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVS 126
                   .|:.|.:.||.:.......|.|......|.|....:.||...||:.:..
  Fly   351 -------QEQQQQQEIQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRP--------- 399

Human   127 AEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMV-ECMYGRNYQ 190
                      |.|.:...|...:.||...:.||..|:.:|.||..|..::.|:|| ..|...:|:
  Fly   400 ----------NFPIQSDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYR 454

Human   191 QGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTW 255
            :.|.||::.|.|:.|:|.|||:.:|.:|.:|::|....|.|||||||||..|.||::|.|:.:.|
  Fly   455 KHSLIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVW 519

Human   256 ALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEG 320
            .:.||.|:.||:.:.....|:...||||...|:...:..|.|::|.|:.::|:....|:||||.|
  Fly   520 KIARETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELG 584

Human   321 STFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRE 385
            :.|:|:..|.|.:.:..| ..|.|::...::|:||||:||::.|||.|::.|:......|::|||
  Fly   585 NEFYIIRCGTVTIKKLDE-QQQEQIVANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDRE 648

Human   386 TFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPF 450
            .|...:||.::|:              ||..::|:.::.: |...|||......:||       .
  Fly   649 AFISYLGTIKQLR--------------EKPSSQRNDTSGR-SSTKSLEFDNEYSQVA-------I 691

Human   451 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELC--SPFI 513
            ..|:.|||||.|.||||:||....:  |.|:|.|:|..:|...|.||||:||.::.: |  ||||
  Fly   692 SELKKIATLGCGAFGRVDLVAYNQQ--ALALKIIKKIEVVKQDQIEHVYNEKNVMIK-CRQSPFI 753

Human   514 VKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLK 578
            |:||||::::||||.|:|||:||::|:::..|..|||.|:||...||.|||||||....||||||
  Fly   754 VQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLK 818

Human   579 PENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYEL 643
            ||||:|..:||.|||||||||.:...:||.||.|||||||||:||::|||.:||:|:||||||||
  Fly   819 PENLMLGTDGYCKLVDFGFAKFVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYEL 883

Human   644 LTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKH 708
            |.|..||.||:|:..|..||.||:.:..|.:|.:..:.|:|.||:|.|.||||..:.||.|||:|
  Fly   884 LVGKTPFRGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRH 948

Human   709 RWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGM-PPDELSGWDKDF 762
            .|....:|:.||.:.||||::|.||...|..||.....|... ||:|||||||||
  Fly   949 SWFESLDWQRLKLKQLPSPIKRPLKSWTDLQYFGPSGVENDYEPPEELSGWDKDF 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG2	NP_006250.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		2/6 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..138		0/20 (0%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000305|PubMed:26769964	168..283		46/115 (40%)
		CAP_ED	168..277	CDD:237999	44/109 (40%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000305|PubMed:26769964	286..416		41/129 (32%)
		CAP_ED	286..401	CDD:237999	39/114 (34%)
		STKc_cGK	459..718	CDD:270724	142/260 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	740..762		12/22 (55%)
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999	43/107 (40%)
		CAP_ED	550..663	CDD:237999	39/127 (31%)
		STKc_cGK	700..957	CDD:270724	141/259 (54%)