DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRKG2 and Pka-C1

DIOPT Version :10

Sequence 1:NP_006250.1 Gene:PRKG2 / 5593 HGNCID:9416 Length:762 Species:Homo sapiens
Sequence 2:NP_476977.1 Gene:Pka-C1 / 34284 FlyBaseID:FBgn0000273 Length:353 Species:Drosophila melanogaster


Alignment Length:363 Identity:149/363 - (41%)
Similarity:213/363 - (58%) Gaps:34/363 - (9%)


- Green bases have known domain annotations that are detailed below.


Human   386 TFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSN-WKLSKALSLEMIQLKEKVARFSSSSP 449
            |.|:.|...|.::::||             .||....: |:.:.                ::::.
  Fly     7 TSNKKVDAAETVKEFLE-------------QAKEEFEDKWRRNP----------------TNTAA 42

Human   450 FQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIV 514
            ..:.|.|.|||.|.||||.:|:.|.....:|||.:.|:.:|..||.||..:|||||:.:..||:|
  Fly    43 LDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLV 107

Human   515 KLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKP 579
            .|...||||..:||:||...|||::|.||..|.|.||.|:|..|.:..||:|||.|.:|||||||
  Fly   108 SLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKP 172

Human   580 ENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELL 644
            |||::|::||||:.||||||::..  :|||.||||||:|||:||:||::.:||:|:||:||||:.
  Fly   173 ENLLIDSQGYLKVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMA 235

Human   645 TGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHR 709
            .|.|||.....:..|..|:.|  |:.||.......:||:|.|.:.:.|:|.||||.|:||||..:
  Fly   236 AGYPPFFADQPIQIYEKIVSG--KVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQK 298

Human   710 WLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPE 747
            |....:|..:..:.:.:|.....|||.|.|.||.|..|
  Fly   299 WFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEEE 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRKG2NP_006250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..138
cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000305|PubMed:26769964 168..283
CAP_ED 168..277 CDD:237999
cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000305|PubMed:26769964 286..416 6/29 (21%)
CAP_ED 286..401 CDD:237999 4/14 (29%)
STKc_cGK 459..718 CDD:270724 127/258 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 740..762 4/8 (50%)
Pka-C1NP_476977.1 STKc_PKA 44..333 CDD:271111 138/292 (47%)
Blue background indicates that the domain is not in the aligned region.

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