DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKG2 and Pkg21D

DIOPT Version :9

Sequence 1:	XP_016863902.1	Gene:	PRKG2 / 5593	HGNCID:	9416	Length:	774	Species:	Homo sapiens
Sequence 2:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	336/752 - (44%)
Similarity:	468/752 - (62%)	Gaps:	65/752 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    20 NLTTD--ALR-------NKVTELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNK 75
            |||.|  |||       :::.:|.||:.:..:.:|:...:|...|.:.:|:.:      ..|..:
  Fly    17 NLTKDVQALREMVRSRESELVKLHREIHKLKSVLQQTTNNLNVTRNEKAKKKL------YSLPEQ 75

Human    76 CIQLNKLQDVVHM--QGGSPLQASPDKV-------PLEVHRKTSGLVSLHSRRGA---------- 121
            |.:........|:  ..|..|..||:..       ||.....||. .|...|..|
  Fly    76 CGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSS-ASPSGRTSADEVRPKAMPA 139

Human   122 ---KAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVEC 183
               |.|||||...::..    ..:|....:..||.|:|:.|.||:..|.|||.:|..|::::|:.
  Fly   140 AIKKQGVSAESCVQSMQ----QSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDS 200

Human   184 MYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKA 248
            ||.::...|.::|::||.|.|::|.|.|...|.|..|:|..:.....|||||||||||||||::.
  Fly   201 MYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRV 265

Human   249 ITN-VKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDY 312
            ::. .:.|.|||.|||.||..|...|.|...||||||.||.||.|:.|.||.|.||:|:|..|.|
  Fly   266 LSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTY 330

Human   313 IIREGEEGSTFFILAKGKVKVTQS-TEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEEND 376
            |||:|..|.:||::::|.|:|||. |....:...::||.:|:||||:|||::|.|:|||||....
  Fly   331 IIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPG 395

Human   377 VACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMI--QLKE 439
            |.||.:||::|.:.:|...||::...|        ||.|         ||:...:.|..  :.||
  Fly   396 VECLTLDRDSFKRLIGDLCELKEKDYG--------DESR---------KLAMKQAQESCRDEPKE 443

Human   440 KVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVA--FAMKCIRKKHIVDTKQQEHVYSEK 502
            ::.:........:||:::|||:||||||||||..:::..  ||:||::|:|||||||:||::||:
  Fly   444 QLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSER 508

Human   503 RILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYL 567
            .|:....||||.:|||||:|.||||||||||:|||:|::|||||||::..::|.:.||.:||:||
  Fly   509 HIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYL 573

Human   568 HRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVD 632
            |..||||||||||||:||..||:|:|||||||:||:..|||||||||||||||:|||||||.:||
  Fly   574 HARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVD 638

Human   633 FWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGN 697
            :|:||||::|||.|.||||..|.|.|||||||||:.:.||:.|:|....||:||||..|:||||.
  Fly   639 YWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGY 703

Human   698 LKNGINDIKKHRWLNGFNWEGLKARSLPSPLQREVLY 734
            ...||.|||||:|..||:|:||.::.|..|..|.:.:
  Fly   704 QTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAH 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKG2	XP_016863902.1	None
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	94/202 (47%)
		CAP_ED	185..285	CDD:237999	44/99 (44%)
		CAP_ED	304..419	CDD:237999	54/114 (47%)
		Pkinase	457..717	CDD:278497	167/259 (64%)
		STKc_cGK	463..724	CDD:270724	168/260 (65%)
		S_TK_X	719..>760	CDD:214529	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8772
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4556
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1264
OMA	1	1.010	-	-		QHG57714
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.680