DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atp8b4 and CG33298

DIOPT Version :9

Sequence 1:	XP_687715.4	Gene:	atp8b4 / 559291	ZFINID:	ZDB-GENE-121116-7	Length:	1214	Species:	Danio rerio
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1377	Identity:	430/1377 - (31%)
Similarity:	658/1377 - (47%)	Gaps:	275/1377 - (19%)

- Green bases have known domain annotations that are detailed below.

Zfish     8 ETLRTRRR-----WPGVMAIWKKDVHIE-------EERHVR-----------ANDRDY-NERFSY 48
            |::.|.||     |      ||:.....       |||..|           ...||: |.:|
  Fly   194 ESIYTLRRTEAPPW------WKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQF-- 250

Zfish    49 ADNRIKTAKYNVFTFLPINLFEQFQRFANAYFLVLLILQLIPEISSLSWFTTIVPLVLVLAITAV 113
            ..|:|:|.||.:.:|:|.||.|||.|.||.||:.:::|..:||||:......::|::.||.:|||
  Fly   251 VGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAV 315

Zfish   114 KDATDDYFRHKSDQQVNTRQSQVLIKG---KLQNEKWMNVRVGDVIKLENNQFVAADLLLLSSSE 175
            ||..:|..|..||:::|....:| ..|   :.:..||..:||||::.|.||:.|.||:|||.:|:
  Fly   316 KDLFEDRRRRASDKRINNTTCRV-YDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSD 379

Zfish   176 PYGLCYIETAELDGETNLKVRQALTVTSDLGDDVAKLADFNGEVICEPPNNKLDKFIGTL-YWKD 239
            |.|:|||:|.:||||||||.|:.:....:: ..:...:.|...|..:.|..||.:|.|.| :...
  Fly   380 PQGVCYIDTCDLDGETNLKRREVVRGFEEM-QSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTG 443

Zfish   240 NKYPLDNEKMLLRGCVLRNTEWCFGLVIFAGLQTKLMQNCGRTKFKRTSIDKLMNTLVLWIFGFL 304
            .:.|:..|.:|||...|:||::..|:|::||.:||.|.|....::||:.:::.||..|:|....|
  Fly   444 ERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIIL 508

Zfish   305 ICMGIILAIGNTIWEQSVGSDFWAYLQWKELTVNAVFSGFLTFWSYIIILNTVVPISLYVSVEVL 369
            :.:.::.|||..:|..|.......||...:||.|  ......||:||:||..::|:||||::|:.
  Fly   509 LILCVVGAIGCRMWLSSFTHFPVPYLPPNKLTAN--MESMWIFWTYIVILQVMIPLSLYVTIELC 571

Zfish   370 RLGHSYFINWDRRMYYSRKDTPAEARTTTLNEELGQVEFIFSDKTGTLTQNIMVFNKCSINGKTY 434
            ::...:.|:.:..::.:..:...|.|...:.|||||::.||:|||||||:|.|:|.:|.:||..|
  Fly   572 KILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDY 636

Zfish   435 GDVFDEFGHKVDITEKTPCVDFSFNPLMDRKFRFHD-SSLVEAIKL--EEPLVQEFFRLLALCHT 496
            .....|. .|:......|.     .||:.......| :.|.:...|  ....:|||..:||:|:|
  Fly   637 NHPPSEL-EKIYSKPGAPA-----PPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNT 695

Zfish   497 VM--------------------------------------------------------------- 498
            |:
  Fly   696 VIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSI 760

Zfish   499 ------------------------------------------------------PEERN------ 503
                                                                  |..:|
  Fly   761 PADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNS 825

Zfish   504 ---------------------------------------------EGELVYQAQSPDEGALVTAA 523
                                                         :|..:|:|:||||.|||.||
  Fly   826 ISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAA 890

Zfish   524 RNFGFVFRSRTPETITLYEM---GQAVTYQLLAILDFNNVRKRMSVIVRNPKGQ-LKLYSKGADT 584
            .::.....:|:|..| |..|   |....|::|.:|.|::.||.||::||....| :.||:||||:
  Fly   891 YSYDCCLLNRSPNQI-LVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADS 954

Zfish   585 ILFDRLDPSNEE-----LMFTTSEHLNEFAGEGLRTLALAYKDLDEDVFDEWTKKLLFASTALDN 644
            .:...|.|.:..     |...|.:.|:.:|.||||.|.:|.:.|:...:.:|..:......:|:|
  Fly   955 SIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLEN 1019

Zfish   645 REEKLGALYEEIEQGMMLLGATAIEDKLQEGVPETIACLTLANIKIWVLTGDKLETAMNIGYSCN 709
            ||.:|...:.::|..:.|||||.|||:||:|||||||.|..|.|.:|||||||.|||:||.||..
  Fly  1020 RERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAK 1084

Zfish   710 MLRDDMNEVFIISGHTMLEVQQELRTAKERIMGPSKDKFSSGL-----DMEKTELYSVDSVFEET 769
            :....|..:                    |:...|:|...:.:     |||..:..|.....:..
  Fly  1085 LFTQQMELI--------------------RLTARSRDAAETAINFYLTDMENDKTTSTLGYGQSL 1129

Zfish   770 IIAEYALIINGHSLAHALEAELEQIL--VDVACLCKSVICCRVTPLQKALVVELIKRHKRAVTLA 832
            ...:.||:::|.:|...|:.:.:.||  :.::..|.||:|||.||||||.:|:::|......|||
  Fly  1130 RKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLA 1194

Zfish   833 IGDGANDVSMIKTAHIGVGISGQEGMQAVLASDYSFAQFRYLQRLLLVHGRWSYHRMCNFLCYFF 897
            |||||||||||:.|.:|||||||||||||:|:|::..:||||:||||.||.|.|.|:...:.|||
  Fly  1195 IGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFF 1259

Zfish   898 YKNFAFTLVHFWYGFLCGFSAQTVYDQWFITLFNIVYTSLPVLAMGLFDQDVNEQYSLRYPNLYR 962
            |||.||..:.|||...||||.|.:.||.::.|:|:::||||.||:|::|:.|.|...|:.|.||:
  Fly  1260 YKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYK 1324

Zfish   963 PGQLNQLFNKRKFFTCTLQGVYTSFILFFIPYGAFMPAVRDDGAQISDQQAFAVTIATSLVIVVS 1027
            .|:|...:....|:...|..:|.|.::||:...|:  |..|.|.     ..|..||..|.:....
  Fly  1325 NGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAY--AESDVGI-----WEFGTTITASCLFANL 1382

Zfish  1028 VQIGLDTNYWTAVNHFFIWGSLAVY--FAILF---AMNSNGIFTIFPNQFPFIGSARNSLNQKIV 1087
            |...::...||.::...|..||..:  |||::   .||..|:.:.:...|....||       :.
  Fly  1383 VHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASA-------VH 1440

Zfish  1088 WLVILLNTVVCIMPMLAVRFIKTDLYPTHTDKVRLLQQATRRQRPQEQNLRRVRRTSSRRSAYAF 1152
            ||||:|:|||.::|.|.:..::..|.|..:.|| :||....|.| .|..|....|::|..|.|..
  Fly  1441 WLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKV-ILQSKRERSR-GEALLVTWSRSTSASSIYRI 1503

Zfish  1153 SHQQGYGELITS 1164
            :......::||:
  Fly  1504 TDYGSKNQIITT 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atp8b4	XP_687715.4	PhoLip_ATPase_N	34..99	CDD:292826	27/76 (36%)
		ATPase-Plipid	48..1121	CDD:273734	402/1268 (32%)
		Cation_ATPase	493..591	CDD:289987	40/269 (15%)
		HAD_like	<830..861	CDD:304363	26/30 (87%)
		PhoLip_ATPase_C	861..1115	CDD:292829	92/258 (36%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	23/51 (45%)
		ATPase-Plipid	250..1473	CDD:273734	402/1269 (32%)
		E1-E2_ATPase	302..>394	CDD:278548	39/92 (42%)
		Cation_ATPase	<880..965	CDD:289987	34/85 (40%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	92/258 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830