Protein Alignment PRKG1 and TPK2

DIOPT Version :10

• Sequence 1: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_015121.1
• Gene: TPK2 / 855898
• SGDID: S000006124
• Length: 380
• Species: Saccharomyces cerevisiae
• Alignment Length: 327
• Identity: 132/327 - (40%)
• Similarity: 198/327 - (60%)
• Gaps: 23/327 - (7%)

Human   356 AKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEH 420
            :|.||          .|.||.|:.|||.|.||||.||: .....:.:|:|:|||:.:|..:|.||
Yeast    61 SKGKY----------TLHDFQIMRTLGTGSFGRVHLVR-SVHNGRYYAIKVLKKQQVVKMKQVEH 114

Human   421 IRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE 485
            ...|:::::.....|::|::.||:|::.::|:|:...||||:::||....|.:...:||.|.|:.
Yeast   115 TNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVIL 179

Human   486 AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGH 550
            |..|||:..||||||||||::||..|:.|:.||||||::  ...|||.||||:|:|||:|..|.:
Yeast   180 ALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEV--QTVTWTLCGTPDYIAPEVITTKPY 242

Human   551 DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS 615
            :.|.|:||||:|:||:|.|..||....|||||..||:|  .:.:|.....:..:|:.||...:.:
Yeast   243 NKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQG--KVVYPPYFHPDVVDLLSKLITADLT 305

Human   616 ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPT-DTSNFDSFPED-------ND 672
            .|:|||::|.:||:.|.||....||.|....:..|..|.:.|.. |||.||.:||:       .|
Yeast   306 RRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQYPEEQLDYGIQGD 370

Human   673 EP 674
            :|
Yeast   371 DP 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999
		CAP_ED	237..341	CDD:237999
		STKc_cGK	381..641	CDD:270724	110/259 (42%)
		S_TK_X	636..>679	CDD:214529	15/47 (32%)
TPK2	NP_015121.1	STKc_PKA_like	69..358	CDD:270732	124/293 (42%)