Protein Alignment PRKG1 and aPKC

DIOPT Version :10

• Sequence 1: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 144/505 - (28%)
• Similarity: 235/505 - (46%)
• Gaps: 106/505 - (20%)

Human   203 KLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQG 267
            ::|.:.||.|:.|..:  |:.|.:..:.::...|.|  ||.::.:.|
  Fly   517 RIWGLGRQGFKCIQCK--LLVHKKCHKLVQKHCTDQ--PEPLVKERA------------------ 559

Human   268 ARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVID 332
                              |:|....||.|..|      ..:|:.|         .|||  |...|
  Fly   560 ------------------EESSDPIPVPLPPL------PYEAMSG---------GAEA--CETHD 589

Human   333 RDSFKHLIG------GLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVEL 391
            .   .|::.      .|:..:.:.|                   .|:||.:|..:|.|.:.:|.:
  Fly   590 H---AHIVAPPPPEDPLEPGTQRQY-------------------SLNDFELIRVIGRGSYAKVLM 632

Human   392 VQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA-HSDFIVRLYRTFKDSKYLYMLMEA 455
            |:|: ...:.:|||::||..:.|....:.:::||.:.:.| :..|:|.|:..|:....|:.::|.
  Fly   633 VELR-RTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEF 696

Human   456 CLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF 520
            ..||:|...::.:....:...|||.|.:..|..:||.|||||||||.:|::|||.|:.||.|:|.
  Fly   697 VRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGM 761

Human   521 AKK-IGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPF------SGPDP 578
            .|: |..|..|.||||||.|:||||:..:.:..|.|:|:||:|:||:|.|..||      ..||.
  Fly   762 CKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQ 826

Human   579 MK---TYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLG-NLKNGVKDIQKHKWFEGFNW 639
            ..   .:.:||.  ..|..|:.::..||:::|.....||::||| :.::...||..|.:|:..:|
  Fly   827 NTEDYLFQVILE--KTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDW 889

Human   640 EGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDE----PPPDDNSGWDID 685
            |.|.:..:|||..|.:.|..|.:||.  ||...|    .|.||:...:||
  Fly   890 ELLERKQVTPPFKPRLDSDRDLANFP--PEFTGEAVQLTPDDDHVIDNID 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999	7/23 (30%)
		CAP_ED	237..341	CDD:237999	18/103 (17%)
		STKc_cGK	381..641	CDD:270724	94/271 (35%)
		S_TK_X	636..>679	CDD:214529	16/46 (35%)
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	8/34 (24%)
		STKc_aPKC	620..947	CDD:270740	112/323 (35%)