Protein Alignment PRKG1 and wts

DIOPT Version :10

• Sequence 1: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Alignment Length: 726
• Identity: 171/726 - (23%)
• Similarity: 279/726 - (38%)
• Gaps: 207/726 - (28%)

Human    38 LIQKLQNELDKYRSVIRPATQQAQKQSASTLQG---------EPRTKRQAISAEPTAFDIQDLSH 93
            ::|:.|.:..:.:.|.:...||.|:|....||.         ..|.:|:....|... |.|.|::
  Fly   474 VVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERER-DQQKLAN 537

Human    94 -------VTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQ-EIVDCMYPVEYGKDSCIIKEGD 150
                   :..|.|..:..:...||....:|:   |:::|... .....:.|.:|..:|.......
  Fly   538 GNPGRQMLPPPPYQSNNNNNSEIKPPSCNNN---NIQISNSNLATTPPIPPAKYNNNSSNTGANS 599

Human   151 VGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTI 215
            .|.     .:|....|......|..
  Fly   600 SGG-----SNGSTGTTASSSTSCKK---------------------------------------- 619

Human   216 MMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGT 280
                  |||.            ..:||.  .|::...||   |..|:.|||.:.....|.:.:..
  Fly   620 ------IKHA------------SPIPER--KKISKEKEE---ERKEFRIRQYSPQAFKFFMEQHI 661

Human   281 VNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDD 345
            .||.:....       ||..|...  ||.:                           |.:|..|.
  Fly   662 ENVIKSYRQ-------RTYRKNQL--EKEM---------------------------HKVGLPDQ 690

Human   346 VS---NKAYEDAEAK----AKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFA 403
            ..   .|.....|:.    .:.:.:.:.|..||        .:|||.||.|.||......:..:|
  Fly   691 TQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLK--------PIGVGAFGEVTLVSKIDTSNHLYA 747

Human   404 MKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDR 468
            ||.|:|..::...|..|:::|:.|:..|.::::|:||.:|:|...||.:|:...||:|.::|...
  Fly   748 MKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKL 812

Human   469 GSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWT- 532
            |.||:...|||.|.|..|...:|..|.|:||:||:|:::|..|:.||.|||..  .||   .||
  Fly   813 GIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC--TGF---RWTH 872

Human   533 ------------------------------------------------FCGTPEYVAPEIILNKG 549
                                                            ..|||.|:|||::...|
  Fly   873 NSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSG 937

Human   550 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP--KKIAKNAANLIKKLCRD 612
            :....||||:|:::||:|.|.|||....|::|...::.....:..|  .::::.|.:||::||.
  Fly   938 YTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCA- 1001

Human   613 NPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPD 677
            :..:|||   ..|.:::.|.:|:|.::..:||  ...|.||.:..||||||||  |.|.::...:
  Fly  1002 SADKRLG---KSVDEVKSHDFFKGIDFADMRK--QKAPYIPEIKHPTDTSNFD--PVDPEKLRSN 1059

Human   678 D---NSGWDID 685
            |   :||.|:|
  Fly  1060 DSTMSSGDDVD 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	3/16 (19%)
		CAP_ED	118..227	CDD:237999	12/109 (11%)
		CAP_ED	237..341	CDD:237999	19/103 (18%)
		STKc_cGK	381..641	CDD:270724	93/310 (30%)
		S_TK_X	636..>679	CDD:214529	17/45 (38%)
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	16/109 (15%)
		STKc_LATS	717..1078	CDD:270749	116/375 (31%)