DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKG1 and CG12069

DIOPT Version :9

Sequence 1:	NP_006249.1	Gene:	PRKG1 / 5592	HGNCID:	9414	Length:	686	Species:	Homo sapiens
Sequence 2:	NP_651819.1	Gene:	CG12069 / 43643	FlyBaseID:	FBgn0039796	Length:	356	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	123/307 - (40%)
Similarity:	178/307 - (57%)	Gaps:	10/307 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   372 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFI 436
            |.|:.|..|||.|.||:|:||: :.|....:|.|.|.|..||.|:|..|:.|||.:::.......
  Fly    44 LDDYEIKATLGSGSFGKVQLVR-ERESGVYYASKQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNT 107

Human   437 VRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLK 501
            |.|..::||...||:::....||||:|..|....|.:...|||.|.|..|..|||...::|||||
  Fly   108 VNLIASYKDFDSLYLVLPLIGGGELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLK 172

Human   502 PENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYEL 566
            |||:::|..||.|:.|||||||:  ..:|.|.||||||:.||||.:|.:..|.|:|:.|:|::|.
  Fly   173 PENIMMDKNGYLKVTDFGFAKKV--ETRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEF 235

Human   567 LTGSPPFS--GPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQ 629
            :.|..|||  ..|.|..||.|...  ..:.|...:....:|:..|.:.:.|:|.|||.||.:||:
  Fly   236 VAGHSPFSAHNRDVMSMYNKICEA--DYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIK 298

Human   630 KHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPP 676
            :|:||:...|..|...|:..|.:|::::|.|.||||..   :|:|.|
  Fly   299 EHEWFKDVEWIPLLNQTVNAPYVPNISNPEDISNFDKV---SDKPRP 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999
		CAP_ED	237..341	CDD:237999
		STKc_cGK	381..641	CDD:270724	106/261 (41%)
		S_TK_X	636..>679	CDD:214529	14/41 (34%)
CG12069	NP_651819.1	PTZ00263	44..356	CDD:140289	123/307 (40%)
CG12069	NP_651819.1	PKc_like	45..335	CDD:304357	118/294 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840