Protein Alignment PRKG1 and prkg1a

DIOPT Version :10

• Sequence 1: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Sequence 2: XP_073775545.1
• Gene: prkg1a / 394005
• ZFINID: ZDB-GENE-040426-1308
• Length: 700
• Species: Danio rerio
• Alignment Length: 689
• Identity: 564/689 - (81%)
• Similarity: 609/689 - (88%)
• Gaps: 22/689 - (3%)

Human     1 MGTLRDL--QYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQ 63
            :.|:.||  .:|....::|.|.||     ||..|.::::.|.:|:.:|.|.:||: |:.|..
Zfish    31 VNTMSDLDEDFAKILMLKEERIRD-----LERRLLEREDEISELKRKLHKCQSVL-PSAQIG--- 86

Human    64 SASTLQGEPRTKR-QAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQI 127
                    |||.| |.|||||...  ||||:.:.....||.:||||||.||||||||||||:|||
Zfish    87 --------PRTHRAQGISAEPQTH--QDLSNQSFRRVAKSDRSKDLIKSAILDNDFMKNLEMSQI 141

Human   128 QEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTR 192
            ||||||||||:|.|:|||||||||||||||||||||||||||:||||||||||||||||||||||
Zfish   142 QEIVDCMYPVDYDKNSCIIKEGDVGSLVYVMEDGKVEVTKEGLKLCTMGPGKVFGELAILYNCTR 206

Human   193 TATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHY 257
            ||||:|:.:|||||||||||||||||||||||.||||.||||.||:.||||||||||||||||||
Zfish   207 TATVRTVSSVKLWAIDRQCFQTIMMRTGLIKHAEYMELLKSVLTFRGLPEEILSKLADVLEETHY 271

Human   258 ENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA 322
            |:|.||||||||||||||||||.|.:||||.|.::||:||::|:||.||||||||||:|||||||
Zfish   272 EDGNYIIRQGARGDTFFIISKGKVTMTREDCPGQEPVYLRSMGRGDSFGEKALQGEDIRTANVIA 336

Human   323 AEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFG 387
            ||.||||||||||:|||||||:|||||..||||||||||||.|||:||.||||||||||||||||
Zfish   337 AETVTCLVIDRDSYKHLIGGLEDVSNKGCEDAEAKAKYEAENAFFSNLNLSDFNIIDTLGVGGFG 401

Human   388 RVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYML 452
            |||||||||:|.||||||||||||||||||||||||||.|||.||||||||||||||||||||||
Zfish   402 RVELVQLKSDEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYML 466

Human   453 MEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD 517
            |||||||||||||||||:|:|||||||||||||||||||||||||||||||||||||||||||||
Zfish   467 MEACLGGELWTILRDRGNFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD 531

Human   518 FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTY 582
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   532 FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTY 596

Human   583 NIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTL 647
            ||||||||||||||||.|||||||||||||.||||||||||||||||||||||||||:|||||||
Zfish   597 NIILRGIDMIEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTL 661

Human   648 TPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 686
            .|||||:|.|.|||||||||||||::|||||||||||||
Zfish   662 MPPIIPNVTSSTDTSNFDSFPEDNEDPPPDDNSGWDIDF 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	16/52 (31%)
		CAP_ED	118..227	CDD:237999	98/108 (91%)
		CAP_ED	237..341	CDD:237999	84/103 (82%)
		STKc_cGK	381..641	CDD:270724	251/259 (97%)
		S_TK_X	636..>679	CDD:214529	35/42 (83%)
prkg1a	XP_073775545.1	None