DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKG1 and CG4839

DIOPT Version :9

Sequence 1:	NP_006249.1	Gene:	PRKG1 / 5592	HGNCID:	9414	Length:	686	Species:	Homo sapiens
Sequence 2:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster

Alignment Length:	684	Identity:	272/684 - (39%)
Similarity:	406/684 - (59%)	Gaps:	24/684 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    11 LQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEPRTK 75
            |::|....||:    .:.:.|..|:.|:.|...|..|:     ....:::.|.|.|:.....|.:
  Fly   336 LRKKRSMERQQ----QQKQQEQQQQQEIQQDATNSQDQ-----MAGAEESHKSSDSSTPKTHRVE 391

Human    76 RQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQE-IVDCMYPVEY 139
            ...|...|. |.||  |.:.:....|...:::||:.||..|||:.||...:.:| :::.|.|..|
  Fly   392 GGLIYVRPN-FPIQ--SDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASY 453

Human   140 GKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKL 204
            .|.|.||:|.:.||.:||..:|:.:|.:.|..:.:.||..||||||||||..|.|:::...:.::
  Fly   454 RKHSLIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARV 518

Human   205 WAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGAR 269
            |.|.|:.|:.||..:|..:..|.::||:|.|..|...:.:|.|:.|:|:...||....|:|:|..
  Fly   519 WKIARETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGEL 583

Human   270 GDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA-AEAVTCLVIDR 333
            |:.|:||..|||.:.:.|...::.: :....:||:|||:||...|||.|:|.| |.....|::||
  Fly   584 GNEFYIIRCGTVTIKKLDEQQQEQI-VANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDR 647

Human   334 DSFKHLIGGLDDVSNK-AYEDAEAKAKYEAEAAFFAN----LKLSDFNIIDTLGVGGFGRVELVQ 393
            ::|...:|.:..:..| :.:..:...:...::..|.|    :.:|:...|.|||.|.||||:||
  Fly   648 EAFISYLGTIKQLREKPSSQRNDTSGRSSTKSLEFDNEYSQVAISELKKIATLGCGAFGRVDLV- 711

Human   394 LKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM-QGAHSDFIVRLYRTFKDSKYLYMLMEACL 457
              :...:..|:||:||..:|...|.||:.:||.:| :...|.|||:||||:::.||:|.|||||:
  Fly   712 --AYNQQALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACM 774

Human   458 GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK 522
            ||::||::..|..|::.|.:|...||||||.||||...||||||||||:|...||.|||||||||
  Fly   775 GGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAK 839

Human   523 KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR 587
            .:...:||.||.||||||||||||::|||.:.|||:||||:||||.|..||.|.:.:|.|..||.
  Fly   840 FVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILS 904

Human   588 GIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPII 652
            |||:|..|.:|.|:|.:|::.||:..|:||||..:.|:.||::|.|||..:|:.|:...|..||.
  Fly   905 GIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIK 969

Human   653 PSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 686
            ..:.|.||...|.....:||..||::.||||.||
  Fly   970 RPLKSWTDLQYFGPSGVENDYEPPEELSGWDKDF 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	10/43 (23%)
		CAP_ED	118..227	CDD:237999	40/109 (37%)
		CAP_ED	237..341	CDD:237999	36/104 (35%)
		STKc_cGK	381..641	CDD:270724	139/260 (53%)
		S_TK_X	636..>679	CDD:214529	13/42 (31%)
CG4839	NP_609349.1	Crp	428..577	CDD:223736	54/148 (36%)
		CAP_ED	431..539	CDD:237999	40/107 (37%)
		Crp	544..>650	CDD:223736	39/106 (37%)
		CAP_ED	550..663	CDD:237999	37/113 (33%)
		S_TKc	695..951	CDD:214567	137/258 (53%)
		STKc_cGK	700..957	CDD:270724	138/259 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1041
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.670