DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PRKG1 and Pkg21D

DIOPT Version :9

Sequence 1:NP_006249.1 Gene:PRKG1 / 5592 HGNCID:9414 Length:686 Species:Homo sapiens
Sequence 2:NP_477213.1 Gene:Pkg21D / 33253 FlyBaseID:FBgn0000442 Length:768 Species:Drosophila melanogaster


Alignment Length:762 Identity:372/762 - (48%)
Similarity:489/762 - (64%) Gaps:96/762 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    19 RQRDALIDEL--------ELELDQKDELIQKLQNELDKYRSVIRPAT------------------ 57
            |:|:|::..|        |:...::.||: ||..|:.|.:||::..|                  
  Fly     9 REREAIVSNLTKDVQALREMVRSRESELV-KLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSL 72

Human    58 ------QQAQKQS------------------------------ASTLQGEP--RT---------- 74
                  |:::.|:                              |||....|  ||          
  Fly    73 PEQCGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAM 137

Human    75 ----KRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMY 135
                |:|.:|||.....:|....:.:|.|.|....|..||:||:||||:||::.||::|:||.||
  Fly   138 PAAIKKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMY 202

Human   136 PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLV 200
            .........:|:||:||:.:||...|:..|.::|..|..||.||.||||||||||||||:::.|.
  Fly   203 SKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLS 267

Human   201 N-VKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYII 264
            . .::|.:||:.||.|||.|||.:....:.||:|||...:|.||:|:|:|||||...|..|.|||
  Fly   268 EAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYII 332

Human   265 RQGARGDTFFIISKGTVNVTREDSP-SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA-AEAVT 327
            |||..||:||:||:|.|.||::.:| |.:...||||.:||:|||:||..||.||||:|| :..|.
  Fly   333 RQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVE 397

Human   328 CLVIDRDSFKHLIGGLDDVSNKAYEDAEAK-AKYEAEAAF-----------FANLKLSDFNIIDT 380
            ||.:||||||.|||.|.::..|.|.|...| |..:|:.:.           |.:|||:|..::.|
  Fly   398 CLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVST 462

Human   381 LGVGGFGRVELVQLKSEES-KTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFK 444
            ||:|||||||||:...::. ..||:|.|||||||||:|:|||.||:.||..:.|.||.||||||:
  Fly   463 LGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFR 527

Human   445 DSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDH 509
            |.||:|||:|||:|||:||:|||||||||:..:|...||::||.|||::||||||||||||:||.
  Fly   528 DEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDE 592

Human   510 RGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFS 574
            |||.|:|||||||:||...|||||||||||||||||||||||.:.|||:||||::|||.|:||||
  Fly   593 RGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFS 657

Human   575 GPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNW 639
            .||||:|||:||:|||||.|||.|::.|..|||:||||.||||||....|::||:|||||.||:|
  Fly   658 APDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDW 722

Human   640 EGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 686
            :||....|.||.:..:|.|||...||.||.|.:| |||:.||||.||
  Fly   723 DGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNE-PPDELSGWDADF 768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRKG1NP_006249.1 DD_cGKI-beta 4..55 CDD:213375 13/43 (30%)
CAP_ED 118..227 CDD:237999 51/109 (47%)
CAP_ED 237..341 CDD:237999 59/105 (56%)
STKc_cGK 381..641 CDD:270724 179/260 (69%)
S_TK_X 636..>679 CDD:214529 21/42 (50%)
Pkg21DNP_477213.1 Crp 183..386 CDD:223736 101/202 (50%)
CAP_ED 185..285 CDD:237999 46/99 (46%)
CAP_ED 304..419 CDD:237999 62/114 (54%)
Pkinase 457..717 CDD:278497 175/259 (68%)
STKc_cGK 463..724 CDD:270724 179/260 (69%)
S_TK_X 719..>760 CDD:214529 20/41 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0664
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57714
OrthoDB 1 1.010 - - D123183at33208
OrthoFinder 1 1.000 - - FOG0001832
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100630
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2508
SonicParanoid 1 1.000 - - X815
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.760

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