Protein Alignment PRKG1 and pka1

DIOPT Version :10

• Sequence 1: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_595159.1
• Gene: pka1 / 2539781
• PomBaseID: SPBC106.10
• Length: 512
• Species: Schizosaccharomyces pombe
• Alignment Length: 463
• Identity: 158/463 - (34%)
• Similarity: 236/463 - (50%)
• Gaps: 60/463 - (12%)

Human   224 HTEYMEFLKSVPTFQSLPEEILSKLADVLEETH-----------YENGEYIIRQGARGDTFFIIS 277
            |.|...:...:|  ::|.|...||..|.|..|.           |:|.:.:|.           |
pombe    73 HNESSLWTSGIP--KALEEATKSKKPDSLVSTSTSGCASAHSVGYQNIDNLIP-----------S 124

Human   278 KGTVNVTREDSPSEDPVFLRTLGKGDW---FGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 339
            ....:.:|..|.|......|. |:|:.   .||:....:.:|               ||...|..
pombe   125 PLPESASRSSSQSSHQRHSRD-GRGELGSEHGERRSAMDGLR---------------DRHIRKVR 173

Human   340 IGGLDDVSNKAYEDAE--AKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTF 402
            :..|.|:..:....|:  .|.:|          .:.|||.:.|||.|.||||.||| .:.....:
pombe   174 VSQLLDLQRRRIRPADHTTKDRY----------GIQDFNFLQTLGTGSFGRVHLVQ-SNHNRLYY 227

Human   403 AMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRD 467
            |:|:|:|:.|||.:|.||...|:.|:......||..|:.||:|:|.|:|:|:...||||:::||.
pombe   228 AIKVLEKKKIVDMKQIEHTCDERYILSRVQHPFITILWGTFQDAKNLFMVMDFAEGGELFSLLRK 292

Human   468 RGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWT 532
            ...|.:...:||.|.|:.|..|||...|:|||||||||:||..|:.|:|||||||::. .....|
pombe   293 CHRFPEKVAKFYAAEVILALDYLHHNQIVYRDLKPENLLLDRFGHLKIVDFGFAKRVS-TSNCCT 356

Human   533 FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK 597
            .||||:|:|||||..|.::.:||:||||||::|:|.|.|||...:|||.|..||.|  .:.:|..
pombe   357 LCGTPDYLAPEIISLKPYNKAADWWSLGILIFEMLAGYPPFYSENPMKLYENILEG--KVNYPSY 419

Human   598 IAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSV-ASPTDT 661
            .:..:.:|:..|.:.:.:.|.||||:|..||..|.||...:|:.:....:..|.:|.: |...|:
pombe   420 FSPASIDLLSHLLQRDITCRYGNLKDGSMDIIMHPWFRDISWDKILTRKIEVPYVPPIQAGMGDS 484

Human   662 SNFDSFPE 669
            |.||::.:
pombe   485 SQFDAYAD 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999	1/2 (50%)
		CAP_ED	237..341	CDD:237999	23/117 (20%)
		STKc_cGK	381..641	CDD:270724	116/259 (45%)
		S_TK_X	636..>679	CDD:214529	8/35 (23%)
pka1	NP_595159.1	STKc_PKA_like	199..490	CDD:270732	127/294 (43%)