Protein Alignment PRKG1 and ppk33

DIOPT Version :10

• Sequence 1: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_588234.1
• Gene: ppk33 / 2539202
• PomBaseID: SPCC162.10
• Length: 338
• Species: Schizosaccharomyces pombe
• Alignment Length: 340
• Identity: 102/340 - (30%)
• Similarity: 166/340 - (48%)
• Gaps: 59/340 - (17%)

Human   344 DDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMK-IL 407
            :|..|  :||..| ..:|:         :|.|.|.:.:|.|.:..|.:|:.:..:.: ||:| |.
pombe    11 NDKEN--FEDPNA-TNFES---------VSQFKIRNVIGKGSWSTVFVVKHRQTKQR-FALKCIN 62

Human   408 KKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFE 472
            ||:|  |..:.:.:|:|..::|..:...:.:.|..|:|...:|::.:..|||:|...:..| .|.
pombe    63 KKKH--DEHKIKKLRNEVLLLQSLNHPLLCKFYSEFEDETKIYLVTDLMLGGDLRYHISQR-KFN 124

Human   473 DSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKI----GFGKKTWTF 533
            :|..|.:...:|.|..|:||||:::||:||:|::||.:|:.||.||..|.|:    ...|...|.
pombe   125 ESVIRIWMVELVSALIYIHSKGVLHRDVKPDNILLDEKGHCKLADFNVAAKVHTSSSPSKSNMTV 189

Human   534 --CGTPEYVAPEIILNKGHDIS---ADYWSLGILMYELLTGSPPF-----------------SGP 576
              .|||.|:|||.::   |.:|   :|:|||||..||.|....||                 |..
pombe   190 GRVGTPVYMAPETLI---HAVSYKESDWWSLGITFYECLFQVRPFPNHLLINWIRASEEEKASSA 251

Human   577 DPMKTYNIILRGIDMIEFPKK---IAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFN 638
            |.:.:...|.|       .||   |:|:|.:.:......:..:|||   :..|.:|.|.:|...:
pombe   252 DRLSSALHISR-------DKKLTTISKDARSAVMAFLEMDIKKRLG---HSSKKLQTHPFFCSIS 306

Human   639 WEGLRKGTLTPPIIP 653
            .|.:.||.|||...|
pombe   307 LETVSKGNLTPIFRP 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999
		CAP_ED	237..341	CDD:237999
		STKc_cGK	381..641	CDD:270724	86/289 (30%)
		S_TK_X	636..>679	CDD:214529	7/18 (39%)
ppk33	NP_588234.1	Protein Kinases, catalytic domain	29..302	CDD:473864	87/289 (30%)