Protein Alignment PRKG1 and egl-4

DIOPT Version :10

• Sequence 1: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_001294450.1
• Gene: egl-4 / 176991
• WormBaseID: WBGene00001173
• Length: 783
• Species: Caenorhabditis elegans
• Alignment Length: 717
• Identity: 354/717 - (49%)
• Similarity: 479/717 - (66%)
• Gaps: 42/717 - (5%)

Human     7 LQYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQA----------- 60
            |:.|:..|..:|||:..:::.....:.:.:..:..||.|.||.|||:....|.|
 Worm    72 LEEAISRKDAQLRQQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPS 136

Human    61 ----------QKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILD 115
                      |:::.....|..|.|:.|:|||||.|:.:.   .||..|.|:..:|.:|::|:..
 Worm   137 PRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKP---ATLQHYNKTVGAKQMIRDAVQK 198

Human   116 NDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKV 180
            |||:|.|...||.|:|:|||.:.......:|:||:.|..::|:.:|:::|::||..|..|..|.|
 Worm   199 NDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTV 263

Human   181 FGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIL 245
            .|||||||||||||:|:.|.:|:||.:||..||.|..|.|:.:|::.|.||..|..||:|.|:.:
 Worm   264 MGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRI 328

Human   246 SKLADVLEETHYENGEYIIRQGAR---GDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGE 307
            ||:|||:::.:|:.|.||||||.:   ||.||:|:.|.|.||::.....:|..:|.|.:||:|||
 Worm   329 SKMADVMDQDYYDGGHYIIRQGEKCLQGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGE 393

Human   308 KALQGEDVRTANVIA-AEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF----- 366
            :||.||:|||||:|| |..|..|.:||:||..|||.|:.: .|.|.|.|..|:...|...
 Worm   394 RALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESL-KKDYGDKERLAQVVREPPSPVKIV 457

Human   367 ------FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEK 425
                  ||.:.|.:...:.|||||||||||||.:..:::||||:|.|||:|||||||||||.:|:
 Worm   458 DDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAER 522

Human   426 QIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 490
            .||....:|:||:||:||:|.|::|||:|.||||||||.|||||.|:|.|.|||.|||:|...||
 Worm   523 NIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYL 587

Human   491 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD 555
            |.|.|:||||||||.:|.:.||.||||||||||:..|:||||||||||||:||||||||||.:||
 Worm   588 HRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAAD 652

Human   556 YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKIAKNAANLIKKLCRDNPSERLG 619
            ||:|||.:.||:.|.|||...||||||.:||:|:|.:|.| ::|.|.|..|:||||||||.||||
 Worm   653 YWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLG 717

Human   620 NLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDI 684
            :...||.||:||:||.||:|||||..||.|||:|.|::|.|.:|||::|.||| .|||:.||||.
 Worm   718 SGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDND-VPPDEFSGWDE 781

Human   685 DF 686
            .|
 Worm   782 GF 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	14/47 (30%)
		CAP_ED	118..227	CDD:237999	49/108 (45%)
		CAP_ED	237..341	CDD:237999	53/107 (50%)
		STKc_cGK	381..641	CDD:270724	171/260 (66%)
		S_TK_X	636..>679	CDD:214529	26/42 (62%)
egl-4	NP_001294450.1	CAP_ED	201..314	CDD:237999	50/112 (45%)
		CAP_ED	319..437	CDD:237999	57/118 (48%)
		STKc_cGK	478..739	CDD:270724	171/260 (66%)
		S_TK_X	734..783	CDD:214529	30/49 (61%)