DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PRKDC and TOR1

DIOPT Version :9

Sequence 1:NP_008835.5 Gene:PRKDC / 5591 HGNCID:9413 Length:4128 Species:Homo sapiens
Sequence 2:NP_012600.1 Gene:TOR1 / 853529 SGDID:S000003827 Length:2470 Species:Saccharomyces cerevisiae


Alignment Length:2975 Identity:589/2975 - (19%)
Similarity:1034/2975 - (34%) Gaps:946/2975 - (31%)


- Green bases have known domain annotations that are detailed below.


Human  1568 NTELLKNLDLAVLELMQSS--VDNTKMVSAVLNG-------------MLDQSFRERANQKHQGLK 1617
            |..|..||::.:...|.:|  .|...:.|:..:|             :|::.|||..:...:..|
Yeast    26 NVPLAPNLNVNMNMKMNASRNGDEFGLTSSRFDGVVIGSNGDVNFKPILEKIFRELTSDYKEERK 90

Human  1618 LAT-------TILQHWKKCDSWWAKDSPLETKMAVLALLAK-------ILQIDSSVSFNTSHGSF 1668
            ||:       ..|:|....:.:.|..:.:..|:..|....|       :|.||:.:||.    ::
Yeast    91 LASISLFDLLVSLEHELSIEEFQAVSNDINNKILELVHTKKTSTRVGAVLSIDTLISFY----AY 151

Human  1669 PEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELR---RVLEQLIVAHFPMQSREFP 1730
            .|......|.||.     :|:|    |:|      ...:|.:|   :.|.:|.|           
Yeast   152 TERLPNETSRLAG-----YLRG----LIP------SNDVEVMRLAAKTLGKLAV----------- 190

Human  1731 PGTPRFNNYVDC-MKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQ 1794
            ||....:::|:. :|..|:.|..|         ||          :..|.||....|:..:.:..
Yeast   191 PGGTYTSDFVEFEIKSCLEWLTAS---------TE----------KNSFSSSKPDHAKHAALLII 236

Human  1795 VGLLES----VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDA-IDVLKSR 1854
            ..|.|:    :|:..                .|:|..:|.    |||:....|.:|| |.:.|..
Yeast   237 TALAENCPYLLYQYL----------------NSILDNIWR----ALRDPHLVIRIDASITLAKCL 281

Human  1855 FTKLNESTFDTQITK----------KMGY-YKILDVMYSRL--PKDDVHAKESKINQVFHGSCIT 1906
            .|..|.   |.|:|.          :.|: ...|:.:::.|  .|:.:..|:..:||||...|:.
Yeast   282 STLRNR---DPQLTSQWVQRLATSCEYGFQVNTLECIHASLLVYKEILFLKDPFLNQVFDQMCLN 343

Human  1907 EGNELTKTLIKLCYDAFTENMAGENQLLE--RRRLYHCAAYNCAISVICCVFNELKFYQGFLFSE 1969
                        |       :|.||...:  |.::|.       |..:...||...|...:|.. 
Yeast   344 ------------C-------IAYENHKAKMIREKIYQ-------IVPLLASFNPQLFAGKYLHQ- 381

Human  1970 KPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKK---YIEIRKEAREAANGDSDGPSYMSSLSYL 2031
                   |.:|.:::..  |.|.. ::|..:..|   .|.|...|.|.      ||.....:..:
Yeast   382 -------IMDNYLEILT--NAPAN-KIPHLKDDKPQILISIGDIAYEV------GPDIAPYVKQI 430

Human  2032 ADSTLSEEMSQFDFSTGVQSYSY-----SSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRH 2091
            .|....:..::|.|....::..:     .:....|..|:...|         ::|:| |.:....
Yeast   431 LDYIEHDLQTKFKFRKKFENEIFYCIGRLAVPLGPVLGKLLNR---------NILDL-MFKCPLS 485

Human  2092 ECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKL-GNPIV----PLNIRLFLAKLVI 2151
            :.|.....::.....||||...:|         .:..:...| |.|.:    |:.|..|      
Yeast   486 DYMQETFQILTERIPSLGPKINDE---------LLNLVCSTLSGTPFIQPGSPMEIPSF------ 535

Human  2152 NTEEVFRPYAKHWLSP-LLQLAASENNGGEGI---------------HYMVVEIVATI-LSWTGL 2199
                 .|..|:.|.:. :||.....|:....|               .:.:||.|..: ||:...
Yeast   536 -----SRERAREWRNKNILQKTGESNDDNNDIKIIIQAFRMLKNIKSRFSLVEFVRIVALSYIEH 595

Human  2200 ATP----------------------TGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLV 2242
            ..|                      |.:.....::..|...|...:..|.:.:   .||::|.|.
Yeast   596 TDPRVRKLAALTSCEIYVKDNICKQTSLHSLNTVSEVLSKLLAITIADPLQDI---RLEVLKNLN 657

Human  2243 ECWKDCLSIP--YRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVN 2305
            .|:...|:.|  .||:|...       .|.|..||.:.:.:...|...:|...|.|..  :.|:.
Yeast   658 PCFDPQLAQPDNLRLLFTAL-------HDESFNIQSVAMELVGRLSSVNPAYVIPSIR--KILLE 713

Human  2306 NMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKS 2370
            .::.:::........|...|:...:...|:         |||                       
Yeast   714 LLTKLKFSTSSREKEETASLLCTLIRSSKD---------VAK----------------------- 746

Human  2371 FPPLADRFMNAVFFLLPKFHGVLKTLC---------LEVVLCRVEGMTELYFQLKSKDFVQVMRH 2426
              |..:..:|.   |||||.....|:.         |.||     |..::...||.. |..:::.
Yeast   747 --PYIEPLLNV---LLPKFQDTSSTVASTALRTIGELSVV-----GGEDMKIYLKDL-FPLIIKT 800

Human  2427 RDDERQKVCLDIIYKMMPKLKP---------VELRELLNPVVEFV-SHPSTTCREQMYNI--LMW 2479
            ..|:......:...|.:.:|..         ::..|||..:|..: :..|...|.|...:  ::.
Yeast   801 FQDQSNSFKREAALKALGQLAASSGYVIDPLLDYPELLGILVNILKTENSQNIRRQTVTLIGILG 865

Human  2480 IHDNYRDPESE----TD-NDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRL 2539
            ..|.||..|.|    || :..|....:...:|:||:...|.          .:.|.:..:.|.::
Yeast   866 AIDPYRQKEREVTSTTDISTEQNAPPIDIALLMQGMSPSND----------EYYTTVVIHCLLKI 920

Human  2540 L---ALNSLYSPKIE--VH-FLSLATNFLLEMTSMSPDYPNPM--FEHPLSECEFQEYT------ 2590
            |   :|:|.::..|:  :| |.:|....:..:..:.|...:.|  ....|.|..||:..      
Yeast   921 LKDPSLSSYHTAVIQAIMHIFQTLGLKCVSFLDQIIPTILDVMRTCSQSLLEFYFQQLCSLIIIV 985

Human  2591 -------IDSDWRFRSTVLTPMFVETQASQGTLQ----------TRTQEGSLSARWPVAGQIRAT 2638
                   :||.::         .::..:|...||          ::..||......|:       
Yeast   986 RQHIRPHVDSIFQ---------AIKDFSSVAKLQITLVSVIEAISKALEGEFKRLVPL------- 1034

Human  2639 QQQHDFTLT---QTADGRSSFDWLTGSSTDPLVDHTSPSSDS---------LLFAHKRSERLQRA 2691
                  |||   ...:...|.|.:.......|::...|:.:.         :..|...|..|||:
Yeast  1035 ------TLTLFLVILENDKSSDKVLSRRVLRLLESFGPNLEGYSHLITPKIVQMAEFTSGNLQRS 1093

Human  2692 PLKSVGPDFGKKRLGLPGD--EVDNKVKGAAGRTDLLRLRRRFMRDQ------EKLSLMYARKGV 2748
            .:.::|      :|....|  |:.:::..:     |||:......|:      ..|||:..:.|.
Yeast  1094 AIITIG------KLAKDVDLFEMSSRIVHS-----LLRVLSSTTSDELSKVIMNTLSLLLIQMGT 1147

Human  2749 AEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLF 2813
            :.......| :|:.||:..|..:|     .||.:..:.:..|.|.:......|...|:|: .:..
Yeast  1148 SFAIFIPVI-NEVLMKKHIQHTIY-----DDLTNRILNNDVLPTKILEANTTDYKPAEQM-EAAD 1205

Human  2814 SGILK-EMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVS 2877
            :|:.| .:::....|..|:..|:..:|:..:              .:.:|.|   ||...|:...
Yeast  1206 AGVAKLPINQSVLKSAWNSSQQRTKEDWQEW--------------SKRLSIQ---LLKESPSHAL 1253

Human  2878 AGC--LASLQQPVGIRLL---------------EEALLRLLPAEL--PAKRVRGKARLPPDV--- 2920
            ..|  |||:..|:...|.               :|.|:..|...|  |..        ||::   
Yeast  1254 RACSNLASMYYPLAKELFNTAFACVWTELYSQYQEDLIGSLCIALSSPLN--------PPEIHQT 1310

Human  2921 -LRWVE--------LAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEAL 2976
             |..||        |....:|:|||......:...:..|:|   ..:.|..:...|:....:..|
Yeast  1311 LLNLVEFMEHDDKALPIPTQSLGEYAERCHAYAKALHYKEI---KFIKEPENSTIESLISINNQL 1372

Human  2977 NKQDWVDG-------------EPTEAEK-DFWELASLDCYNH---------------------LA 3006
            |:.|...|             :.|..|| :.||.| |..||.                     |.
Yeast  1373 NQTDAAIGILKHAQQHHSLQLKETWFEKLERWEDA-LHAYNEREKAGDTSVSVTLGKMRSLHALG 1436

Human  3007 EWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEA---------DQSLL 3062
            ||:.|...:.            :.|.....|...|       :..|..|.|         :|.:.
Yeast  1437 EWEQLSQLAA------------RKWKVSKLQTKKL-------IAPLAAGAAWGLGEWDMLEQYIS 1482

Human  3063 TFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLT 3127
            ....|:...|...|||.||           ::|.|.|..:|.|.....:   :.|..|:::| ..
Yeast  1483 VMKPKSPDKEFFDAILYLH-----------KNDYDNASKHILNARDLLV---TEISALINES-YN 1532

Human  3128 KLQSV----QALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCF 3188
            :..||    |.:||.:|.|.:  ||...:|:..| ...|.||.|....:.: :::|..::..|..
Yeast  1533 RAYSVIVRTQIITEFEEIIKY--KQLPPNSEKKL-HYQNLWTKRLLGCQKN-VDLWQRVLRVRSL 1593

Human  3189 FLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFS 3253
            .:.                      |...:::.                  :|..:..||.....
Yeast  1594 VIK----------------------PKQDLQIW------------------IKFANLCRKSGRMR 1618

Human  3254 LAMKLLKELHKESKTRDDWLVSWVQS-----YCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVS 3313
            ||.|.|..|.:..  .|..|.:..::     |.:|.:.  .:.|..::.|               
Yeast  1619 LANKALNMLLEGG--NDPSLPNTFKAPPPVVYAQLKYI--WATGAYKEAL--------------- 1664

Human  3314 SYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSS----EDSEKVI 3374
                         |.|:|.|.| :|:.|..:|       .:...:.::||.:|:    |:..|::
Yeast  1665 -------------NHLIGFTSR-LAHDLGLDP-------NNMIAQSVKLSSASTAPYVEEYTKLL 1708

Human  3375 AGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAEL 3439
            |..:.:         |.....|..|:|.......::.:|: ||...|:...|...|.::   |..
Yeast  1709 ARCFLK---------QGEWRIATQPNWRNTNPDAILGSYL-LATHFDKNWYKAWHNWAL---ANF 1760

Human  3440 QAYPALVVEKMLKALK--------LNSNEARL---------------KFPRLLQIIERYP----- 3476
            :....:..|..|...|        :|::..|:               ::|  |::|:|:.     
Yeast  1761 EVISMVQEETKLNGGKNDDDDDTAVNNDNVRIDGSILGSGSLTINGNRYP--LELIQRHVVPAIK 1823

Human  3477 --------------EETLSLMT--------KEISSV-----PCWQFISWISHMVALLDK----DQ 3510
                          ::||.|:|        ||:|..     ...:..:|:..:..|:.:    |.
Yeast  1824 GFFHSISLLETSCLQDTLRLLTLLFNFGGIKEVSQAMYEGFNLMKIENWLEVLPQLISRIHQPDP 1888

Human  3511 AV--AVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQD--- 3570
            .|  ::...:.::...:|||:|||..::.:|             |.|:|.|:.|   .:|:.   
Yeast  1889 TVSNSLLSLLSDLGKAHPQALVYPLTVAIKS-------------ESVSRQKAAL---SIIEKIRI 1937

Human  3571 ----FINALDQLSNPELL-------------FKDWSNDVRAELAKTPVNKKNIEKMY---ERMYA 3615
                .:|..:.:|: ||:             .:|.|.....|        .|||||:   |.::.
Yeast  1938 HSPVLVNQAELVSH-ELIRVAVLWHELWYEGLEDASRQFFVE--------HNIEKMFSTLEPLHK 1993

Human  3616 ALGDPKAPGLGAFRRKFIQTFGK-EFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGN 3679
            .||:..            ||..: .|.|.||:           |.||....  |...|.||...|
Yeast  1994 HLGNEP------------QTLSEVSFQKSFGR-----------DLNDAYEW--LNNYKKSKDINN 2033

Human  3680 LKECSPWMSDFKVEFLRN--------------------------ELEIPGQYDGRGKPLPEYHVR 3718
            |.:.  |  |......|.                          ||.:||.| ..|||.    :|
Yeast  2034 LNQA--W--DIYYNVFRKITRQIPQLQTLDLQHVSPQLLATHDLELAVPGTY-FPGKPT----IR 2089

Human  3719 IAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQ 3783
            ||.|:...:|::|.:||::..|:|.|.:::.:::||.||:|||..|.|||.::|.:|..||.|.:
Yeast  2090 IAKFEPLFSVISSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFK 2154

Human  3784 RALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSG 3848
            |.|.::.|..:|::.:.||:.|:.|:.|...|:     :|.:     |.:..|...:.|      
Yeast  2155 RHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLI-----REHR-----DAKKIPLNIEHW------ 2203

Human  3849 KHDVGAYMLMYKGANRTETVTSFRKRESKVPA-------DLLKRAFVRMSTSPEAFLALRSHFAS 3906
                    :|.:.|...|.:|..:|.|....|       ||.|..::: |.|.|.:|..|:.:..
Yeast  2204 --------VMLQMAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLK-SRSSETWLERRTTYTR 2259

Human  3907 SHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM 3971
            |.|::.::.:|||:||||.:|.|:...||.||.||||..|.:|......||.:||||||.   |.
Yeast  2260 SLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLTRM---LT 2321

Human  3972 LPMKETGLMYSIMV---HALRAFRSDPGLLTNTMDVFVKEPSFDW-------KNFEQ-------- 4018
            ..|:.:|:..|..:   :.:|..|.:...|...::.|..:|...|       |..||        
Yeast  2322 YAMEVSGIEGSFRITCENVMRVLRDNKESLMAILEAFALDPLIHWGFDLPPQKLTEQTGIPLPLI 2386

Human  4019 ---KMLKKGGSWIQE---INVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDY 4077
               ::|:||...::|   :...::|.....:.....|::.          :.|.|::        
Yeast  2387 NPSELLRKGAITVEEAANMEAEQQNETKNARAMLVLRRIT----------DKLTGND-------- 2433

Human  4078 VAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPW 4127
              :.|.::            |....||..|:.|||....|.:.:.||.|:
Yeast  2434 --IKRFNE------------LDVPEQVDKLIQQATSIERLCQHYIGWCPF 2469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRKDCNP_008835.5 HEAT 1 288..323
HEAT 2 1004..1040
Interaction with C1D. /evidence=ECO:0000269|PubMed:9679063 1503..1538
Leucine-zipper 1503..1538
TPR 1 1723..1756 7/33 (21%)
NUC194 1816..2202 CDD:400469 82/431 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2050..2073 3/27 (11%)
KIP-binding 2436..3212 173/923 (19%)
FAT 3023..3470 CDD:396714 85/491 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3200..3222 1/21 (5%)
PIKKc_DNA-PK 3719..4015 CDD:270716 94/312 (30%)
FATC 4097..4128 CDD:396715 11/31 (35%)
TOR1NP_012600.1 TEL1 279..2470 CDD:227365 523/2653 (20%)
HEAT repeat 588..620 CDD:293787 3/31 (10%)
HEAT repeat 632..658 CDD:293787 7/28 (25%)
HEAT repeat 668..698 CDD:293787 8/36 (22%)
HEAT repeat 706..736 CDD:293787 4/31 (13%)
HEAT repeat 749..778 CDD:293787 7/31 (23%)
HEAT_EZ 771..820 CDD:290247 9/54 (17%)
HEAT repeat 792..827 CDD:293787 4/35 (11%)
DUF3385 827..986 CDD:288698 34/168 (20%)
Rapamycin_bind 1952..2049 CDD:285924 31/133 (23%)
PIKKc_TOR 2090..2366 CDD:270713 93/303 (31%)
FATC 2439..2470 CDD:280430 11/43 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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