Protein Alignment myo18ab and zip

DIOPT Version :9

• Sequence 1: XP_021322097.1
• Gene: myo18ab / 559005
• ZFINID: ZDB-GENE-080423-1
• Length: 2267
• Species: Danio rerio
• Sequence 2: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0265434
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1979
• Identity: 526/1979 - (26%)
• Similarity: 918/1979 - (46%)
• Gaps: 443/1979 - (22%)

Zfish   513 VCARMTCWSEQVE-EDP-VAILKADHAAAAHPKVKTEEQIAAEQAWYGSEKVWLVHKDGFSLATV 575
            :.|:|   ||:|: .|| :..|..:......|..:.|        |.....||:.|::...:|..
  Fly    42 IAAKM---SEEVDRNDPELKYLSVERNQFNDPATQAE--------WTQKRLVWVPHENQGFVAAS 95

Zfish   576 VKTEAGSLPEGKVKIKLEHDGTVLDVDEDDVEKANPPSFDRCEDLAALLYLNESSVMHSLRQRYG 640
            :|.|.|.    :|:::|...|..:.:..||::|.|||.||:.||:|.|..|||:||:|:::.||.
  Fly    96 IKREHGD----EVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYY 156

Zfish   641 GNLIHTHAGPNMVIVNPISAPSMYSEKVMHMFKGCRREDTAPHIYAVAQSAYRNLLTTRQDQSIV 705
            ..||:|::|...|:|||.....:|:||:|..:||.:|.:..||::|:..|||||:|..|:||||:
  Fly   157 SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSIL 221

Zfish   706 LLGKSGSGKTTNCQHLVQYLVSIAGS----TG---------------------KIFTAEKWQAVY 745
            ..|:||:|||.|.:.::|:|..:|.|    :|                     ||....:.|.:.
  Fly   222 CTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIE 286

Zfish   746 T---------------------------ILEAFGNSATSMNNNASRFSQIVSLDFDQAGQVASAS 783
            .                           |||||||:.|..|:|:|||.:.:.::||.:|.::.|:
  Fly   287 VVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGAN 351

Zfish   784 IQTMLLEKLRVVKRPETESTFNVFYYMMAGADSTLRTELHFNHFAENSAF---GIVPQSKPEDKQ 845
            |:|.||||.|.:::.:.|.||::||.::|||....|.:...:. .::.||   |.:|....:|
  Fly   352 IETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDD-VKSYAFLSNGSLPVPGVDD-- 413

Zfish   846 KASQQFTKLQA---AMKVLGISSDEQKALWLILGAIYHLGAAGATKAEADEAGRKQFARHEWAQK 907
                 :.:.||   :|.::|::|::..:::.|:.|:...|:....:...::  :.....:..|||
  Fly   414 -----YAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNND--QATLPDNTVAQK 471

Zfish   908 AAYLLGCTLEELSSAIFKHQPKGTLQRSTSFRQGPDDAGTGDNSGPKITALE----CLEAMAAGL 968
            .|:|||.::.:::.|....:.|                 .|.:...|....|    .:||:|...
  Fly   472 IAHLLGLSVTDMTRAFLTPRIK-----------------VGRDFVTKAQTKEQVEFAVEAIAKAC 519

Zfish   969 YSELFTLVISLVNRALKSSQHSLCSLL-IVDTPGFQNPKLAKRERGATFEELCHNYAQERLQTLF 1032
            |..:|..:::.:||:|..::....|.: |:|..||:..:|      .:||:||.||..|:||.||
  Fly   520 YERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFEL------NSFEQLCINYTNEKLQQLF 578

Zfish  1033 HERTFVQELERYKEENIELALDDIESSTSLSVAAIDQASSQALVRTLARTDEARGLLWLMEEEAL 1097
            :...|:.|.|.|:.|.||....|.         .:|      |..|:...|:..|::.|::||..
  Fly   579 NHTMFILEQEEYQREGIEWKFIDF---------GLD------LQPTIDLIDKPGGIMALLDEECW 628

Zfish  1098 QPGGSEETLLERLFSYYS--PADGESKGPALLLKSD--KPHHFLLGHSHGTDWVEYDAGGWLSHA 1158
            .|..:::|.:::|.|.:|  |.         .:|:|  ....|.:.|..|.  |:|.|..||. .
  Fly   629 FPKATDKTFVDKLVSAHSMHPK---------FMKTDFRGVADFAIVHYAGR--VDYSAAKWLM-K 681

Zfish  1159 KQNPASQNAAILLQDSQKKNISSLFMGRSGGATVLSGSIAGLEGGSQLALRRATSMRKTFTTGVA 1223
            ..:|.::|...|||.||...:.:::..            |.:.|.:|.||        |.|...|
  Fly   682 NMDPLNENIVSLLQGSQDPFVVNIWKD------------AEIVGMAQQAL--------TDTQFGA 726

Zfish  1224 AVKK---KSLCIQVKLQVDALMDTVRRSRVHFVHCLLPKAETLSADVKVPGGESCDTGLMQLDVC 1285
            ..:|   :::....|.|:..||||:|.:..:||.|::|..|..:..:..|
  Fly   727 RTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAP--------------- 776

Zfish  1286 LLRAQLRGSKLLDALRIYRQGYPDHLVFSEFRRRFDVLTPHLTKKHGRNYIVTDEKRAVEELLES 1350
            |:..|||.:.:|:.:||.|||:|:.:.|.|||:|:::|||::..|.     ..|.|:|.|:::::
  Fly   777 LVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-----FMDGKKACEKMIQA 836

Zfish  1351 LELEKSSYHMGLSRVFFRAGVLAKLEENRDIQTRRNLTLFQAACRGYLARQAFKKRKIQDLAIRC 1415
            |||:.:.|.:|.|::||||||||.|||.||.:....:..|||.|||:|||:.::||..|..|||.
  Fly   837 LELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRI 901

Zfish  1416 IQKNIKKNRGVKGWPWWKLFTTVRPLIEVQLTEEQIRGKDEEIQLLKSKLE-------------- 1466
            ||:|......::.|.||:|:|.|:||:||...||::..|::|::.::.||:
  Fly   902 IQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQ 966

Zfish  1467 ---------------------KVEKERNELRLNSDRLESKITELSSELADERNT-----GE---- 1501
                                 :.|:.|:.|......||..:.||.:.:.:|...     ||
  Fly   967 QALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKL 1031

Zfish  1502 -----SASQLLESETSERLRLEKDMKDLQAKFDAMKKQTESMEME-------VMEARLI--RASE 1552
                 ...:.||.|.:.|.:|:.:...|.||   :||..|.:.:.       :.|.:|:  ||::
  Fly  1032 ELNIQDLEEQLEEEEAARQKLQLEKVQLDAK---IKKYEEDLALTDDQNQKLLKEKKLLEERAND 1093

Zfish  1553 LNGEMDDDDTG----GEWRLKYERAIREIEFTKKRLQQEFDDKLEVEQQNKRQLERKLTDLQAD- 1612
            |:..:.:::..    .:.:.|:|..|.|:|   :||.::...:.| ..::||::|.::.||:..
  Fly  1094 LSQTLAEEEEKAKHLAKLKAKHEATISELE---ERLHKDQQQRQE-SDRSKRKIETEVADLKEQL 1154

Zfish  1613 NE---EVQRVAQQLKKKCQRLTAELQDTKLHLEGQQSRNHDLEKKQRKFDSEQTQAQEEVQREKS 1674
            ||   :|..:..||.|:.:.||    .|.|.::.:.:.....:|.||:.:|:..:.||:::.||:
  Fly  1155 NERRVQVDEMQAQLAKREEELT----QTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKA 1215

Zfish  1675 QREKLSREKDMLTGEVFSLRQQLEDKDLEICAVNLKLEQMEAELQDLNSQESKDEASLAKIKKQL 1739
            .|.|..:.:..|:.|:.:|:.:|.| .|:..|...:|             .||.|..||.:||.|
  Fly  1216 ARAKAEKVRRDLSEELEALKNELLD-SLDTTAAQQEL-------------RSKREQELATLKKSL 1266

Zfish  1740 RDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERLRQTHSKEIESKEDEVEEIRQSCSKKLK 1804
                      |||.....|.              :..:|..||:|:.|..|::|.:|:: ...|:
  Fly  1267 ----------EEETVNHEGV--------------LADMRHKHSQELNSINDQLENLRKA-KTVLE 1306

Zfish  1805 QMEVQLEEEYEDKQKVLR---------EKRDMEAKLMSAQDQVSHRDVEAEKRLRKDL--KRTKA 1858
            :.:..||.|..|....||         ::|..:|:...|:.||...::|   |.|.:|  |.||.
  Fly  1307 KAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIE---RARSELQEKCTKL 1368

Zfish  1859 LLADAQIMLDHLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKSMEVEIEDLHVQMDDISKSKQ 1923
                              ::|...:.|||||:|...:||||:..:||.::.:....:::.::.|.
  Fly  1369 ------------------QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKL 1415

Zfish  1924 ALEEQLSRLQREKNDLQSRMEEDQEDMNELMKKHKAAVAQSSQNLAQI-------SDLQAQLEEA 1981
            .|..:|.:::.||..||.::|||    :|..:.::..:|:.:..:.:|       :||..:|||.
  Fly  1416 GLSSKLRQIESEKEALQEQLEED----DEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEG 1476

Zfish  1982 MKEKQDVQEKLTALQSQLE--FQEQSMVDKS---LVSRQEAKIRELETK----LEFEKTQVKRLE 2037
               |:.:.:.:.||:.|::  ..:...:|||   :.|..|....|||.:    ||.||.| |..:
  Fly  1477 ---KKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQ-KNFD 1537

Zfish  2038 SLVARLKENLEKLTEERDQRSASENREKE--------------------QNKRLLRQIRDIKEEM 2082
            .::|..|...|::.:||| .:..|.||||                    :|||     :.::.|:
  Fly  1538 KILAEEKAISEQIAQERD-TAEREAREKETKVLSVSRELDEAFDKIEDLENKR-----KTLQNEL 1596

Zfish  2083 AELAKKEAEASRKKHE-------LEMDIESLEAANQSLQADLKLA-----------------FKR 2123
            .:||..:..|.:..||       ||..:..|:|.|:.|:.||:|.                 |:|
  Fly  1597 DDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFER 1661

Zfish  2124 IGDLQAAIEDEMESDDNEDLINSLQDMVTKYQKR----------KNKIEG---ASDTDSEVEDRV 2175
              ||.|  ::|...:....|:..|:|:.|:..:.          |.|:||   ..:|..|:.::|
  Fly  1662 --DLLA--KEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKV 1722

Zfish  2176 --DGVKSWLSKNKGSAKN-LSDDGSLKSSRYAVNVDGKEGKEWEEGKEWKESGKAHPPAADAFAL 2237
              |.:|. ..|.:...|: |.|....|:::..:....||.:.           |.....|:...|
  Fly  1723 KEDALKH-AKKLQAQVKDALRDAEEAKAAKEELQALSKEAER-----------KVKALEAEVLQL 1775

Zfish  2238 TD--LTRKRKKKKRKGARAEAPTAHATNA 2264
            |:  .:.:|.::..:..|.|.....|.||
  Fly  1776 TEDLASSERARRAAETERDELAEEIANNA 1804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo18ab	XP_021322097.1	Atrophin-1	14..>529	CDD:331285	7/17 (41%)
		Myosin_head	554..2053	CDD:332202	454/1661 (27%)
		MYSc_Myo18	629..1368	CDD:276837	224/808 (28%)
		SMC_N	<1939..>2169	CDD:330553	75/302 (25%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/40 (25%)
		Myosin_head	133..854	CDD:278492	231/820 (28%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	224/808 (28%)
		Myosin_tail_1	931..2011	CDD:279860	226/975 (23%)
		Prefoldin	1431..1515	CDD:298833	22/90 (24%)
		FAM76	<1847..1926	CDD:292665

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810