DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myo18ab and Mhc

DIOPT Version :9

Sequence 1:XP_021322097.1 Gene:myo18ab / 559005 ZFINID:ZDB-GENE-080423-1 Length:2267 Species:Danio rerio
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1948 Identity:503/1948 - (25%)
Similarity:915/1948 - (46%) Gaps:388/1948 - (19%)


- Green bases have known domain annotations that are detailed below.


Zfish   521 SEQVEEDPVAILKADHAAAAHPKVKTEEQIAAEQAWYGSEK-VWLV-HKDGFSLATVVKTEAGSL 583
            :.|.:|||...|          .|..|::...:...|.|:| .|:. .|:|:.|.. :|...|.:
  Fly     6 ANQEDEDPTPYL----------FVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGE-IKATKGDI 59

Zfish   584 PEGKVKIKLEHDGTVLDVDEDDVEKANPPSFDRCEDLAALLYLNESSVMHSLRQRYGGNLIHTHA 648
                |.:.|: .|.|.|:..:.|||.|||.|::.||:|.:..||...|:|:|||||...||:|::
  Fly    60 ----VSVGLQ-GGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYS 119

Zfish   649 GPNMVIVNPISAPSMYSEKVMHMFKGCRREDTAPHIYAVAQSAYRNLLTTRQDQSIVLLGKSGSG 713
            |...|.:||.....:|:.:...|::|.||.:..|||:|::..||.::||...:||:::.|:||:|
  Fly   120 GLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAG 184

Zfish   714 KTTNCQHLVQYLVSIAGSTGKIFTAEKW------QAVYT--ILEAFGNSATSMNNNASRFSQIVS 770
            ||.|.:.::.|..:: |::.|...|.|.      |.|.|  :||||||:.|..|:|:|||.:.:.
  Fly   185 KTENTKKVIAYFATV-GASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIR 248

Zfish   771 LDFDQAGQVASASIQTMLLEKLRVVKRPETESTFNVFYYMMAGA-----DSTLRTELHFNHFAEN 830
            :.|...|::|.|.|:|.||||.||:.:...|.::::||.:|:|:     |..|.|:..::     
  Fly   249 IHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYD----- 308

Zfish   831 SAFGIVPQSKP-----EDKQKASQQFTKLQAAMKVLGISSDEQKALWLILGAIYHLGAAGATKAE 890
              :.||.|.|.     :|    :::|:....|..:||.:..|::.::.|..|:.|:|.     .:
  Fly   309 --YHIVSQGKVTVASIDD----AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGG-----MK 362

Zfish   891 ADEAGRKQFARHEWAQ---KAAYLLGCTLEELSSAIFKHQPKGTLQRSTSF-RQGPDDAGTGDNS 951
            ..:.||::.|..:..:   :.:.|.||...||    :|:..|..::....| .||.:.....::.
  Fly   363 FKQRGREEQAEQDGEEEGGRVSKLFGCDTAEL----YKNLLKPRIKVGNEFVTQGRNVQQVTNSI 423

Zfish   952 GPKITALECLEAMAAGLYSELFTLVISLVNRALKSSQHSLCSLLIVDTPGFQ----NPKLAKRER 1012
            |          |:..|::..||..::...|..|.:.|.....:.::|..||:    |        
  Fly   424 G----------ALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN-------- 470

Zfish  1013 GATFEELCHNYAQERLQTLFHERTFVQELERYKEENIELALDDIESSTSLSVAAIDQASSQALVR 1077
              .||:||.|:..|:||..|:...||.|.|.||.|.|:.|..|.....   :|.||      |: 
  Fly   471 --GFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDL---LACID------LI- 523

Zfish  1078 TLARTDEARGLLWLMEEEALQPGGSEETLLERLFSYYSPADGESKGPALLLKSDKP----HHFLL 1138
                 ::..|:|.::|||::.|..:::|..|:|.:.:.......:.|    |..||    .||.:
  Fly   524 -----EKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKP----KPPKPGQQAAHFAI 579

Zfish  1139 GHSHGTDWVEYDAGGWLSHAKQNPASQNAAILLQDSQKKNISSLF---MGRSGGATVLSGSIAGL 1200
            .|..|.  |.|:..|||...| :|.:.......:.||.|.:..:|   .|:|||.....|. .|.
  Fly   580 AHYAGC--VSYNITGWLEKNK-DPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGG-RGK 640

Zfish  1201 EGGSQLALRRATSMRKTFTTGVAAVKKKSLCIQVKLQVDALMDTVRRSRVHFVHCLLPKAETLSA 1265
            :||.             |.|..:|.|:         |:::||.|:|.::.|||.|::|.      
  Fly   641 KGGG-------------FATVSSAYKE---------QLNSLMTTLRSTQPHFVRCIIPN------ 677

Zfish  1266 DVKVPGGESCDTGLMQLDVCLLRAQLRGSKLLDALRIYRQGYPDHLVFSEFRRRFDVLTPHLTKK 1330
            ::|.||         .:|..|:..||..:.:|:.:||.|:|:|:.:::.:|:.|:.::.|.|.:.
  Fly   678 EMKQPG---------VVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQG 733

Zfish  1331 HGRNYIVTDEKRAVEELLESLELEKSSYHMGLSRVFFRAGVLAKLEENRDIQTRRNLTLFQAACR 1395
                  |..:|:|.|.:::.::|.:..|.:|.::||||||||.::||.||.:..:.::..||..|
  Fly   734 ------VEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792

Zfish  1396 GYLARQAFKKRKIQDLAIRCIQKNIKKNRGVKGWPWWKLFTTVRPLIEVQLTEEQIRGKDEEIQL 1460
            |||:|:.|||.:.|.:|::.:|:|::|...::.|||:||:..|:||:.|...|       :||..
  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE-------DEIAR 850

Zfish  1461 LKSKLEKVE-------KERNELRLNSDRLESKITELSSELADERNTGESASQLLESETSERLRLE 1518
            |:.|.:|.|       |.|.||...:.:|.::.|.|...|:.|:...:...:.....|:::..||
  Fly   851 LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLE 915

Zfish  1519 KDMKDLQAKF----DA-----------------MKKQTESMEMEVMEARLIRASE------LNGE 1556
            ..::|:|.:.    ||                 :||..|.:|:.|.:|...:|::      ||.|
  Fly   916 NQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDE 980

Zfish  1557 MDDDD-------------------TGGEWRLKYERAIREIEFTKKRLQQ---EFDDKLEVE---- 1595
            :...|                   ||.|.:.. |..|..:...|.:|:|   |.:|.||.|    
  Fly   981 IAHQDELINKLNKEKKMQGETNQKTGEELQAA-EDKINHLNKVKAKLEQTLDELEDSLEREKKVR 1044

Zfish  1596 ---QQNKRQLE--RKLT-----DLQADNEEVQRVAQQLKKKCQRLTAELQDTKLHLEGQQSRNHD 1650
               :::||::|  .|||     ||:.:.:|:::..|:..|:...:||:|:|.::.:...|.:..:
  Fly  1045 GDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKE 1109

Zfish  1651 LEKKQRKFDSE-QTQAQEEVQREKSQREKLSREKDML---------------------TGEVFSL 1693
            |:.:..:.:.| :.:.|...:.|| ||..|:||.:.|                     ..|:..|
  Fly  1110 LQARIEELEEEVEAERQARAKAEK-QRADLARELEELGERLEEAGGATSAQIELNKKREAELSKL 1173

Zfish  1694 RQQLEDKDL--EICAVNLK------LEQMEAELQDLNSQESKDEASLAKIKKQLRDLEAKV---- 1746
            |:.||:.::  |....||:      :.:|..::..||..::|.|....:...||.||.|.|    
  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHIT 1238

Zfish  1747 -----------------KDQEEELDEQAGTIQMLEQAKLRLEME-MERLRQTHSKEIESKEDEVE 1793
                             .:.:.:|||...|:...:.:|.:|.:| .:.|||.  :|.||:..::.
  Fly  1239 NEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQL--EEAESQVSQLS 1301

Zfish  1794 EIRQSCSKKLKQMEVQLEEEYEDKQKVLREKRDMEAKLMSAQDQVSHRDVEAEKRLRKDLKRTKA 1858
            :|:.|.:.:|:..:...:||..::..:|.:.|::|..|.:.::|| ..:.|.:..|::.|.:.. 
  Fly  1302 KIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQV-EEEAEGKADLQRQLSKAN- 1364

Zfish  1859 LLADAQIMLDHLKNNAPSK-REIAQLKNQLE----ESEFT-------CAAAVKARKSMEVEIEDL 1911
              |:||:.....:::..:: .|:.:.|.:|:    |:|.|       |....|.::.:..|:|||
  Fly  1365 --AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDL 1427

Zfish  1912 HVQMDDIS-------KSKQALEEQLSRLQREKNDLQSRMEEDQED----MNELMKKHKA------ 1959
            .:::|..:       |.::|.::.:...:.:.:||.:.::..|::    ..||.:...|      
  Fly  1428 QLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQE 1492

Zfish  1960 ---AVAQSSQNLA-QISDLQAQLEEAMKEKQDVQEKLTALQSQLEFQEQSMVDKSLVSRQEAKIR 2020
               ||.:.::||| ::.||..|:.|..:...::::    .:.:||.::..:         :|.:.
  Fly  1493 QLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEK----ARKRLEAEKDEL---------QAALE 1544

Zfish  2021 ELETKLEFEKTQVKRLESLVARLKENLEKLTEERDQRSASENREKEQNKRLLRQIRDIKEEMAEL 2085
            |.|..||.|:.:|.|.:..::::::.:::..:|:::.  .||..|...:.|......::.|    
  Fly  1545 EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEE--FENTRKNHQRALDSMQASLEAE---- 1603

Zfish  2086 AKKEAEASRKKHELEMDIESLE-------AANQSLQADLKLAFKRIGDLQAAIEDEMESDD---- 2139
            ||.:|||.|.|.:||.||..||       .||...|.::|...:::.|:|.|:|:|..:.|    
  Fly  1604 AKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDARE 1668

Zfish  2140 ----NEDLINSLQDMVTKYQKRKNKIEGASDTDSEVEDRVDGVKSWLSKNKGSAKNLSDDGS--- 2197
                :|...|:||:   :.::.:..:|.|.....:.|..:......|  |:.||:|.|...:   
  Fly  1669 QLGISERRANALQN---ELEESRTLLEQADRGRRQAEQELADAHEQL--NEVSAQNASISAAKRK 1728

Zfish  2198 LKSSRYAVNVD----GKEGKEWEEGKEWKESGKAHPPAADAFALTDLTR------KRKKKKRK 2250
            |:|....::.|    ..|.|..||        ||.....||..|.|..|      :.::|.||
  Fly  1729 LESELQTLHSDLDELLNEAKNSEE--------KAKKAMVDAARLADELRAEQDHAQTQEKLRK 1783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myo18abXP_021322097.1 Atrophin-1 14..>529 CDD:331285 3/7 (43%)
Myosin_head 554..2053 CDD:332202 437/1688 (26%)
MYSc_Myo18 629..1368 CDD:276837 214/771 (28%)
SMC_N <1939..>2169 CDD:330553 59/258 (23%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 12/42 (29%)
MYSc 81..777 CDD:214580 231/802 (29%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 214/771 (28%)
Myosin_tail_1 842..1897 CDD:279860 222/989 (22%)
V_Alix_like 1557..1877 CDD:187408 61/246 (25%)
ATP-synt_B <1671..1771 CDD:304375 27/112 (24%)
TMPIT 1739..>1825 CDD:285135 15/53 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.