Protein Alignment PRKCZ and pck1

DIOPT Version :10

• Sequence 1: XP_016857278.1
• Gene: PRKCZ / 5590
• HGNCID: 9412
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_593737.2
• Gene: pck1 / 2542293
• PomBaseID: SPAC17G8.14C
• Length: 988
• Species: Schizosaccharomyces pombe
• Alignment Length: 524
• Identity: 171/524 - (32%)
• Similarity: 261/524 - (49%)
• Gaps: 114/524 - (21%)

Human   103 PGLPC----------------------PGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCG 145
            |||.|                      ...:||.:  |..|:|     ..|.|:........:|.
pombe   438 PGLQCENCSFVCHKKCVTKVLASCIAQSNSEKSDF--GGLRYR-----IPHRFEPFNSLGAQWCA 495

Human   146 QCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQ---EPPVDDKNEDADLPSE 207
            .|...:....:..::|:.|.:..|.:|..|:|..|  .|.:.:..|   |..|..:.:..:||::
pombe   496 HCGFFLPLRRKDCFKCVECGITCHGQCAHLIPDYC--GMSNDLKHQLLTELEVSKRPKKPELPNQ 558

Human   208 E---TDGIAY---ISSSRKHDSI----------------------------KDDSEDLKP----- 233
            |   |:...|   :||....|::                            ||.|.::.|
pombe   559 ENKTTNEKVYRKPLSSQNTFDTLPTISQGLLAATQPVTSVLNTSPLPKTPEKDRSLNVTPSSSTP 623

Human   234 ----VIDGMDGIKISQG------------------LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQ 276
                |:.......:|..                  :.|.||..:.|:|:|::.||:|...|.|.:
pombe   624 TPASVLAPPSSASLSSSKDANRSVPESPRREKKNRVTLDDFTFLAVLGKGNFGKVMLAEYKVNKK 688

Human   277 IYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS--SNPFLVGLHSCFQTTSRLRRLSPCRLFLVIE 339
            .||:||:|||.:..:|:::.::|||||||.|:  .:|||:.|.:.|||::        |::.|:|
pombe   689 FYAIKVLKKEAILKNEELESLKTEKHVFEVANKEKHPFLLNLFASFQTST--------RVYFVME 745

Human   340 YVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYG 404
            |:.|||||.|:||| :...:.||||.||:|:||.:.||.||.||||||||:||..||||::.|||
pombe   746 YILGGDLMVHIQRQ-QFSVKRARFYGAEVCLALKYFHENGIAYRDLKLDNILLCPDGHIRIADYG 809

Human   405 MCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMN 469
            :|||.:..|:|||||||||.::|||||..::|...|||||.||||::|:.|:|||       ...
pombe   810 LCKENMLLGNTTSTFCGTPEFMAPEILLEQQYSKDVDWWAFGVLMYQMLLGQSPF-------KGE 867

Human   470 TEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLM 534
            .|:.:|..||......|..:...|..:|:|.|.:||.:|||..|:.. :::.:|.||.||.||.:
pombe   868 DEEEIFDAILSDEPLFPINMPADAVSLLRGLLTRDPNQRLGSGPKDA-NEVMAHPFFASIVWDDL 931

Human   535 HRQL 538
            :.:|
pombe   932 YNKL 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCZ	XP_016857278.1	PB1_aPKC	16..98	CDD:99725
		C1	129..183	CDD:412127	11/53 (21%)
		Protein Kinases, catalytic domain	236..537	CDD:473864	133/320 (42%)
pck1	NP_593737.2	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1	111..180	CDD:469609
		C2	212..316	CDD:472691
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	4/25 (16%)
		C1_ScPKC1-like_rpt2	477..535	CDD:410373	13/64 (20%)
		STKc_PKC	668..983	CDD:270722	130/285 (46%)