Protein Alignment PRKCZ and pkc-3

DIOPT Version :9

• Sequence 1: XP_016857278.1
• Gene: PRKCZ / 5590
• HGNCID: 9412
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_495011.1
• Gene: pkc-3 / 173914
• WormBaseID: WBGene00004034
• Length: 597
• Species: Caenorhabditis elegans
• Alignment Length: 609
• Identity: 311/609 - (51%)
• Similarity: 386/609 - (63%)
• Gaps: 54/609 - (8%)

Human    14 GRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTVSSQMELEE 78
            |.::||..:.|.:.:.........::....::|.|:.|::..:|:||:|.:|||.::.|||||:|
 Worm    11 GDIKLKTRFQGQVVVLYARPPLILDDFFALLKDACKQHKKQDITVKWIDEDGDPISIDSQMELDE 75

Human    79 AFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAY 143
            |.|.....::..|.||||...||.|||||.||||::||||||||:|:|..|||.|||||.|||..
 Worm    76 AVRCLNSSQEAELNIHVFVGKPELPGLPCQGEDKTVYRRGARRWKKIYLYNGHRFQAKRLNRRIQ 140

Human   144 CGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMD--SVMPSQEPPVDDKNEDADLPS 206
            |..|.:.|||:.|||:||::|:|.|||:||..|...|.:.:.  :::|........|...::..|
 Worm   141 CFICHDYIWGIGRQGFRCVDCRLCVHKKCHRHVRTHCGQALQGPNIIPMAPASGSLKGARSNTSS 205

Human   207 EETDGIAYISSSRKH----DSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVL 267
            ..|.....|.:...|    :|....|.|....::|....|  ..:.|.||.|:.||||||||||:
 Worm   206 STTRSGGGIDNGAFHEHEIESPGSTSHDASRAMNGNGSSK--WAVSLNDFRLLTVIGRGSYAKVV 268

Human   268 LVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLRRLSPC 332
            ........||||:|::|||:.::|||||||||||.|||.||:.||||||||||||.|
 Worm   269 QAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTES-------- 325

Human   333 RLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGH 397
            |||.|||:|.|||||||||:||||||||||||:.||.:||:|||.||||||||||||||:||:||
 Worm   326 RLFFVIEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGH 390

Human   398 IKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII 462
            |||||||||||.:..||.||||||||||||||||||:|||||||||||||||||||||||||||:
 Worm   391 IKLTDYGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIV 455

Human   463 -TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCR--PQTGFSDIKSHA 524
             ..|.:.||||||||:|||:.|||||.|||:||.:|||||||||.|||||:  ...|..|:|.|.
 Worm   456 GMQNSEENTEDYLFQIILERQIRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQ 520

Human   525 FFRS-IDW--------------------DLMHRQLRCTDARTTWTPRRCGRTDDMDAQTMWMHGR 568
            |||. |||                    ||.|...:.||.....:|      |:.|...
 Worm   521 FFRGFIDWEALEQKAVAPPYHPAVESDRDLTHFDHQFTDELPQLSP------DNPDVIA------ 573

Human   569 RRHTDDSSTDDSDARTPRRRGRTD 592
              ..|.|..|..:...|.:..|.|
 Worm   574 --RIDQSEFDGFEYVNPLQMSRED 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCZ	XP_016857278.1	None
pkc-3	NP_495011.1	PB1_aPKC	13..95	CDD:99725	26/81 (32%)
		C1_1	128..178	CDD:278556	27/49 (55%)
		S_TKc	253..522	CDD:214567	200/276 (72%)
		PKc_like	257..586	CDD:304357	215/350 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	423	1.000	Domainoid score	I345
eggNOG	1	0.900	-	-		E2759_KOG0695
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	701	1.000	Inparanoid score	I378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45540
OrthoDB	1	1.010	-	-		D133170at33208
OrthoFinder	1	1.000	-	-		FOG0003559
OrthoInspector	1	1.000	-	-		otm16250
orthoMCL	1	0.900	-	-		OOG6_104397
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2598
SonicParanoid	1	1.000	-	-		X2434
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910