Protein Alignment UNC45A and unc-45

DIOPT Version :10

• Sequence 1: NP_061141.2
• Gene: UNC45A / 55898
• HGNCID: 30594
• Length: 944
• Species: Homo sapiens
• Sequence 2: NP_524796.1
• Gene: unc-45 / 44910
• FlyBaseID: FBgn0288846
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 942
• Identity: 342/942 - (36%)
• Similarity: 548/942 - (58%)
• Gaps: 38/942 - (4%)

Human    19 SSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASK 83
            |.....:.:|||.||...:..|:..|.:|:...:..::.||.::||||.:|||..|:.|..:.::
  Fly    11 SDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTE 75

Human    84 AIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSS 148
            :::...||.|||:||:||.|.|.:.::|..|.......:|.||..|..|:.:...::|:....:.
  Fly    76 SLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNAK 140

Human   149 TDAKVEQMFQILLD---PEEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDM-GET 209
            |..||:||..:..|   |    .:|::.|:.||||||:|..|||.:::.:.:..:..|..: .:.
  Fly   141 TSTKVKQMMDLTFDLATP----IDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQ 201

Human   210 DLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACHLLQVMFDALKEGVKK 274
            |:.:..:..:..:|.....||...|:.||....:.:|..:.:.....|...||.:.:|| .|:|.
  Fly   202 DIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNAL-SGLKN 265

Human   275 GFRGK-EGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLW 338
            ....| |..:.....||:..|::.|:..:|:..:||..||..:.|:.:.|...:|:        |
  Fly   266 KPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNVHYTALE--------W 322

Human   339 ----VIDQGLKKILEVGGSLQDPPGELA--VTANSRMSASILLSKLFDDLKCDAERENFHRLCEN 397
                |..:||.::|:|...|:|...|.|  :|.:|...||:.|:::::::..|..:..|....:.
  Fly   323 AERLVEIRGLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDE 387

Human   398 YIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQEEEQLVAVEALI 462
            |||.......:..|:|....::.||.||.|.||:.:...|:::.::|:..::.|.:|.|:.|.||
  Fly   388 YIKDKLLAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLI 452

Human   463 HAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLA 527
            .|:.|..:|..:...||.:||.||. |:.|.||:|||||||||||.||.|.:::.|.:|:.||||
  Fly   453 AASSKKDKAKALCEQGVDILKRLYH-SKNDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLA 516

Human   528 KQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASA 592
            :.||::|.....|...||||.:||||||.||:.||:.:||.|::.||..|:|...:|.|:.|.:.
  Fly   517 EACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGGNQSCLYGVVTT 581

Human   593 LVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMVCMVKTESP 657
            .||..|:|:.:|..|:|:||||:||||:||:|..|...|:..|:..|...|:.:|:..:.||||
  Fly   582 FVNLCNAYEKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTES- 645

Human   658 VLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAAQALAKLTITSNPE 722
               .:.:||::||..|:....|.||.||.:||.:||:.:|||||:.|:..|.||||::.||.|||
  Fly   646 ---HNSQELIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPE 707

Human   723 MTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEE 787
            ::|.|:|..:|:|||::||..:|:.|:|||:||||||||.::|.:||:|:||:.|..||.|:.|:
  Fly   708 VSFSGQRSLDVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRIIKEQGVSKIEYYLMED 772

Human   788 HEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLQRAAAGGLAMLTSMRPTL 852
            |..:.|||.:|:|||.||::|..:||. .|||:|.|.|...::||....|.||.||::||:....
  Fly   773 HLYLTRAAAQCLCNLVMSEDVIKMFEG-NNDRVKFLALLCEDEDEETATACAGALAIITSVSVKC 836

Human   853 CSRIPQVTTHWLEILQALLLSSNQELQHRGAVVVLNMVEASREIASTLMESEMMEILSVLAKGDH 917
            |.:|..:.: ||:||..|:.:.:..:||||.|::|||:.|..|||..|.|:::||:||.|  |..
  Fly   837 CEKILAIAS-WLDILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGL--GQL 898

Human   918 SPVTRA-----AAACLDKAVEYGLIQPNQDGE 944
            ...|||     |..||..|..|.:|:.:.:.|
  Fly   899 PDDTRAKAREVATQCLAAAERYRIIERSDNAE 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC45A	NP_061141.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		1/1 (100%)
		TPR 1	21..54		8/32 (25%)
		TPR repeat	21..49	CDD:276809	8/27 (30%)
		NlpI	<28..>125	CDD:443815	33/96 (34%)
		TPR repeat	57..87	CDD:276809	11/29 (38%)
		TPR 2	58..91		11/32 (34%)
		TPR 3	92..125		12/32 (38%)
		TPR repeat	92..120	CDD:276809	11/27 (41%)
		UNC45-central	363..505	CDD:432011	47/141 (33%)
		armadillo repeat	768..803	CDD:293788	17/34 (50%)
		armadillo repeat	806..842	CDD:293788	14/35 (40%)
unc-45	NP_524796.1	3a0801s09	7..>127	CDD:273380	38/115 (33%)
		TPR repeat	16..41	CDD:276809	8/24 (33%)
		TPR repeat	46..79	CDD:276809	11/32 (34%)
		UNC45-central	351..494	CDD:432011	47/143 (33%)
		PLN03200	399..>700	CDD:215629	131/305 (43%)
		armadillo repeat	753..789	CDD:293788	18/35 (51%)
		armadillo repeat	795..826	CDD:293788	13/31 (42%)