Protein Alignment ASH1L and SET2

DIOPT Version :10

• Sequence 1: NP_001353106.1
• Gene: ASH1L / 55870
• HGNCID: 19088
• Length: 2969
• Species: Homo sapiens
• Sequence 2: NP_012367.2
• Gene: SET2 / 853271
• SGDID: S000003704
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 546
• Identity: 138/546 - (25%)
• Similarity: 236/546 - (43%)
• Gaps: 122/546 - (22%)

Human  2096 CNC-KKPDDDTRKGCVD--DCLNRMIFAECSPNTC-PCGEQCCNQRIQRHEWVQCLERFRAEEKG 2156
            |:| ::..|.....|.:  ||:||:...||..:.| .||..|.|||.|:.::.. :..|:.:.||
Yeast    68 CDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAP-IAIFKTKHKG 131

Human  2157 WGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDH-YCLNLDSGMVIDSYRMGNEARF 2220
            :|:|.::.::|.|||.||.|||:.|.|||:|:|:....|..| |.:.|.:|..||:...|:.|||
Yeast   132 YGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARF 196

Human  2221 INHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIG 2285
            .||||.||..:.||.|....|:|::|.:.:..|.|:|:|||...:..:.|: |.|....|.|.:|
Yeast   197 CNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQK-CYCEEPNCIGFLG 260

Human  2286 GKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEP---SENINTPTRLTPQL 2347
            ||:|     |.:.:..|.......|.:....|...||||    ||.||   :||.|........|
Yeast   261 GKTQ-----TDAASLLPQNIADALGVTVSMEKKWLKLKK----LSGEPIIKNENENINIEFLQSL 316

Human  2348 QMKPMSNRERNFVLKHHVFLVRNWEKIRQKQ----------EEVKHTSDNIHSASLYTRWNGICR 2402
            :::|:.:...  |.|....|::...||...:          :.::|.:..:|.   ||.::.:.:
Yeast   317 EVQPIDSPVD--VTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHG---YTCFSKMLK 376

Human  2403 DDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQAL 2467
                    :|:|:      ...|..:.....|::|         :..|.|.|.::....::|..:
Yeast   377 --------LFITE------QPQVDGKGNETEEDDI---------KFIKGILDFLLELPKTTRNGI 418

Human  2468 AAPLLN-----LPPK----KKNAD----------YYEKISDPLDLITIEKQILTGYYKTVEAFDA 2513
            .:..::     ||.|    |.|.|          .|::|:        :|.|.....|.:
Yeast   419 ESSQIDNVVKTLPAKFPFLKPNCDELLEKWSKFETYKRIT--------KKDINVAASKMI----- 470

Human  2514 DMLKVFRNAEKYYGRKSPVGRDVCRL--RKAYYNARHE-----------------ASAQIDEI-- 2557
            |:.:|          :.|.|.::...  |..||||..:                 ::.|::..
Yeast   471 DLRRV----------RLPPGWEIIHENGRPLYYNAEQKTKLHYPPSGSSKVFSSRSNTQVNSPSS 525

Human  2558 --VGETASEADSSETSVSEKENGHEK 2581
              :.:|....||.:..:|::|...:|
Yeast   526 SGIPKTPGALDSKKHKLSDEEYERKK 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASH1L	NP_001353106.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..143
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..525
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..583
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	824..845
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	878..966
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1100..1128
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1151..1231
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1281
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1489..1508
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1580..1711
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1741..1761
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1911..1991
		Catalytic domain	2069..2288		74/196 (38%)
		AWS	2092..2143	CDD:197795	18/50 (36%)
		SET_ASH1L	2146..2286	CDD:380951	54/140 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2288..2346		16/60 (27%)
		Bromo_ASH1	2443..2548	CDD:99955	24/125 (19%)
		PHD_ASH1L	2586..2628	CDD:277023
		BAH_polybromo	2665..2799	CDD:240068
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2825..2856
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2876..2919
SET2	NP_012367.2	AWS	64..119	CDD:197795	18/50 (36%)
		SET_SETD2	119..260	CDD:380949	54/142 (38%)
		WW_1	479..505	CDD:375933	6/25 (24%)
		TolA	545..>626	CDD:442298	2/7 (29%)
		SRI	627..703	CDD:462404