|
Human 22 SPSAISTGTLVSKREVELEKNTKEEEDLRKRNRER------NIEAGKDDGLTDAQQ---QFSVKE 77
:|..:......::||.|.....|::|: .|:.||: |..:|.:.|..|..| ||||||
Zfish 11 TPPPLPANAPPAEREKEGVGGKKDDEE-EKKKREKLRDGAQNEASGAESGTGDQPQQPTQFSVKE 74
Human 78 TNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRPAIKTTIKHP--------------------RKA 122
|::||||:||||||||||.|||||.|||||||||.:.|::|. ..:
Zfish 75 TSYSEGNVKLKIGLQAKRMKKPPKILENYVCRPAFRATVRHSGGRGGGRANRGAGASDANSNSTS 139
Human 123 LKSGKMTDEK----------------------------------NEHCPSKRDPSKLYKKADDVA 153
..:||..::| |.:.|:||.|.||..|::..|
Zfish 140 TSNGKEGEKKPSVNRGASQSAAAPAASTPSPSLPPASINTVTPVNGNAPAKRGPPKLACKSEGKA 204
Human 154 AIE--CQSEEVIRLH---SQGENNPLSKK--LSPVHSEMADYINATPSTLLGSRDPDL------- 204
.:: ..||:.:.|| ::.:::...|| :...:|..|....|.|......:||.:
Zfish 205 DVKSVASSEKPLNLHRPTTESKSHSSGKKNHVPQTNSAPAPSPPAVPPAATSQQDPKIDGILKTP 269
Human 205 ----------KDRALLNGGT-SVTEKLAQLIATCPPSKSSKTKPKKLGT----GTTAGLVSKDLI 254
::|.:.:.|| :||||||||||||||||..|.|.:|:.. .::..|:| :|.
Zfish 270 QCNFLEGQKEQERGISSWGTPTVTEKLAQLIATCPPSKCPKPKARKVSPAPAHSSSPPLIS-NLQ 333
Human 255 RKAGVGSVAGIIHKDLIKKPTISTAVGLVTKDPGKKPVFNAAVGLVNKDSVKKLGTGTTAVFINK 319
|. .:.:..:.|.|.||.|....|..:|. ....|..||||:.:..:||:....:.
Zfish 334 RP----------ERAMANRNTYSRAVHLAQPPPVSRPP-GRPYGSKNKDSILEKFSGTSKKEESD 387
Human 320 NLGK------KPGTITTVGLLSKDSGKKLGIGIVPGLVHKESGKKLGLGTVVGL-----VNKDLG 373
.|.| ...|.||...||::|.: |.|.... :|...|
Zfish 388 GLSKGVSGSSSTTTTTTSSALSQNSSR--------------------LTTTTSTNESTDINNTDG 432
Human 374 KKLGSTVGLVAKDCAKKIVASSAMGLVNKDIGKKLMSCPLAGLISKDAINLKAEALLPTQEPLKA 438
.|..|.:| .|.....:::| |.|.:...|.:.| .
Zfish 433 MKSQSRLG----HCPSHSSSAAA-------------SPPFSSSSSVERI---------------G 465
Human 439 SCSTNINNQESQELSESLKDSATSKTFEKNVVRQNKESILEKFSVRKEIINLEKEMFNEGTCIQQ 503
|.|.|| .|..|.||:. :...|.:|.||.:.:..:.||: .
Zfish 466 STSCNI----------GLPGSLTSRP-------KASPSRIEDFSEKDKERDREKD---------T 504
Human 504 DSFSSSEKGSYETSKHEKQPPVYCTSPDFKMGGASDVSTAKSPFSAVGESNLPSPSPTVSVNPLT 568
||.....||. .|......| |.:..:..:|.:..|:|: :|:.
Zfish 505 DSPRDLSKGI---------TPAITGKQD-----AKERCSLSAPRNDRGKSS----------SPVK 545
Human 569 RSP-PETSSQLAPNPLLLSSTTELIEEISESVGKNQFTSESTHLNVGHRSVGHSISIECKGIDKE 632
||| .|:.....|:| :|||...:.
Zfish 546 RSPNQESRVSGVPSP-----------------------AESTKCTIS------------------ 569
Human 633 VNDSKTTHIDIPRISSSLGKKPSLTSESSIHTITPSVVNFTSLFSNKPFLKLGAVSASDKHCQVA 697
|...|...:.| |.:.:.| ||:|.:....|
Zfish 570 -----------PSYPSGASRSP------------PPLCDDT-----------GAISPASPSEQ-- 598
Human 698 ESLSTSLQSKPLKKRKGRKPRWTKVVARSTCRSPKGLELERSELFKNVSCSSLSNSNSEPAKFMK 762
.|||||||:||:|||||.|:|:. .||..|.|
Zfish 599 -------DSKPLKKRRGRRPRWTKAVSRTH--------------------KSLHESPS------- 629
Human 763 NIGPPSFVDHDFLKRRLPKLSKSTAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIY--- 824
:|..:...:|.....::| :....|:| ||.|.....| |||:
Zfish 630 --------NHQQIPTPMPSGLSFSSP---IRESVEQP---------LSDSYTSPED--SDIFDSS 672
Human 825 KPKRGRPKSKEMPQLEGP-----PKRTLKIPASKVFS--LQSKEEQEPPILQPEIEIPSFKQGLS 882
..||||||:| ||:|:.| |. |:..||.|| |:|||||:||:|.||::....|.
Zfish 673 PKKRGRPKTK-MPRLDAPAHGCTPN---KLAPSKSFSSLLKSKEEQDPPVLHPEVDFNPPKM--- 730
Human 883 VSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLESESDNHRSSSDFFESEDQLQDPDD 947
..:||||||| .||.| ..:.|.|..
Zfish 731 ---MARKRGRPKR--------SPPTL------------------------------PQETQPPTL 754
Human 948 LDDSHRPSVCSMSDLEMEPDKKITKRNNGQL-MKTIIRKINKMKTLKRKKLLNQIL--------- 1002
..:|...|| .:|....:.|||| |||||.|||||||:|||:||:|||
Zfish 755 APESGEASV---------GEKPFRNKGNGQLIMKTIIGKINKMKTVKRKRLLSQILLGPKPAEEQ 810
Human 1003 SSSVESSNKGKVQSKLHNTVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGILSGSP 1067
..|..|...|...:....:::|||||||.|||.|||||||||||:||||||||||..|. ..|:|
Zfish 811 ECSRSSGPTGSPVATKPQSLTSLAATFGGKLGPQINVSKKGTIYMGKRRGRKPKTSTNP-SPGAP 874
Human 1068 T-----------------SLAVLEQTAQQAAGSALGQILPPLLPSSASSSEILPSPICSQSSGTS 1115
| .:..|:....| ||| ||:.|||..||| |
Zfish 875 TPPPEPFLSPNTSSPHHHQVQALQNQPHQ---------LPP--------SEVFPSPSLSQS---S 919
Human 1116 GGQSPVSSDAGFVEPSSVPY------LHLH----------------------SRQGSMIQTLAMK 1152
|||||: |||.||||.||.: .|.| |...|.......|
Zfish 920 GGQSPI-SDASFVEPGSVHFSSHPHCSHSHQVHHSFSFPPPTFSAPSARSVASAATSTAHPSQKK 983
Human 1153 KASKG-------------RRRLSPP-TLLPNSPSHLSELTSLKEATPSPISESHSDETIPSDSGI 1203
.:.:| .|:.||| .|||.||:.||| ||||||||:|||||:||:||||||
Zfish 984 SSCRGYHHHHHHYRQHYHYRKFSPPRPLLPTSPAPLSE---LKEATPSPVSESHSEETVPSDSGI 1045
Human 1204 GTDNNSTSDRAEK-----------------------------------FCGQKKRRHS----FEH 1229
||||||||||.|| ...:.:|||| .|.
Zfish 1046 GTDNNSTSDRGEKAGSANGLPGVGVSQGMAGGLLMPGVIGPGIGTGIGLSSRGRRRHSSSVLLER 1110
Human 1230 VSLIP--------PE--------TSTVLSSLKEKHKHKCKRRNHDYLSYDKMKRQKRKRKKKYPQ 1278
.|..| |: .|:.|...|||||||||||.|...||||:|||||||||||.|
Zfish 1111 PSPTPSPLGVRASPDPRRSHPAAPSSALVGHKEKHKHKCKRRGHGCPSYDKLKRQKRKRKKKYLQ 1175
Human 1279 LRN-RQDPDFIAELEELISRLSEIRITHRS----------------------------------- 1307
||: ||||||:|:|:|:..:||:|||:||:
Zfish 1176 LRSRRQDPDFLADLDEICVQLSDIRISHRTPTLRLGSSIGLGAGAGPGRGSGLGSTRPSSSLGGG 1240
Human 1308 -----HHFIPRDLLPTIFRINFNSFYT-HPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFM 1366
||::.||||||||||||:.:|: ||::|.|.|||:||||||||||||||:||:::|:||:
Zfish 1241 TNPPPHHYLHRDLLPTIFRINFSGYYSPHPAYPCDSLHYVRKPDLKKKRGRPPKLRESISEVPFV 1305
Human 1367 HSLSFPLSSTGFY-PSYGMPYSPSPLTAAPIGLGYYGRY--PPTLYPPP-------------PSP 1415
..|.|||||.||| ||||:|||.:|| |||||..| |..|||.| .||
Zfish 1306 PGLGFPLSSGGFYHPSYGVPYSSTPL-----GLGYYRGYTPPSALYPHPHHQAPHSGPSHHVHSP 1365
Human 1416 SFTTPLPPPSYM---HAGHLLLNPAKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAYGW 1477
||..| |||||: |..||||||:|:||||||||||| :|...|:.:| ||::..|:::||
Zfish 1366 SFPPP-PPPSYVHHHHPSHLLLNPSKFHKKKHKLLRQE-YLGGGRSSML----YPAMSSELSFGW 1424
Human 1478 MVEHKHRHRHKHREHRSSEQPQVSMDTG--------------------SSRSVLESLKRYRFGKD 1522
.|||:||||||:....|:.. |.| ..|..:|||:..|||:|
Zfish 1425 --HHKHKHRHKHRDRCGEEEGD---DGGGVLGGIGGRGVGGEGLGAGRGERGSVESLQHCRFGRD 1484
Human 1523 ----------------------AVGERYKHKEKHRCHMSCPHLSPSKSLINRE-------EQWVH 1558
:..||||.|| ..||| |.||:..:... :.|..
Zfish 1485 GSADSRTNKQSASANSPSSSSTSSAERYKRKE---ASMSC--LGPSRLSLGTASRGHHPVDSWFR 1544
Human 1559 REPSESSPLALG---------------LQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHTNLFT 1608
...|::....|. :|.| :|||||... ...:|..||..| .|||||.
Zfish 1545 MGSSDTDYSKLSRNQSFSGSGAFSEGHVQNP--VDCSESDEE---DAASPIEEPEIS-HHTNLFA 1603
Human 1609 SAIGSCRVSNPNSSGRKKLTDSPGLFSAQDTSLNRLHRKESLPSNERAVQTLAGSQPTSDKPSQR 1673
||:. |.| |.||:.....|.:.
Zfish 1604 SALS--RTS------------------------------------------LKGSRSKKGGPLES 1624
Human 1674 PSESTNCSPTRKRSSSESTSSTVNGVPSRSPRLVASGDDSVDSLLQRMVQNEDQEPMEKSIDAVI 1738
||.|......|:..|:.|....:..|.|...|:..|....|...|.....:....|:..|..|..
Zfish 1625 PSLSRLDRTVRRDRSTSSEKREIGNVSSLQNRVGQSSVPDVSEGLHHRHHHHHHPPLSLSHAASC 1689
Human 1739 ---ATASAPPSSSPGRSHSKDRTLGKPDSLLVPAVTSDSCNNSISLLSEKLTSSCSPHHIKRSVV 1800
.|...|.:::|.|..|:..:.....| .||...|| .|.|:....
Zfish 1690 LPHCTLDQPGNTAPLRPSSRQASPSTCSS--QPACCLDS----------------PPSHLSHRP- 1735
Human 1801 EAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRR-PGRPRKCPLQAVVSM 1864
..|.||.||||||:|||||||||||||.||:| ||||||.||.:..:.
Zfish 1736 -----------------PPKNNLLHVNKILRAKKLQRQARTGNNMVKKRGPGRPRKNPLPSPPAT 1783
Human 1865 QAFQAAQFVNPELNRDEEGAALHLSPDTVTDVIEAVVQSVNLNPEHKKGLKRKGWLL-------E 1922
...|.::..|..|.......|| ...|||.|.||||||: :.|||.|||.|.. |
Zfish 1784 PPPQTSEQDNHPLPERHRATAL-WEADTVVDAIEAVVQN-----QRKKGRKRKHWERETEGGDEE 1842
Human 1923 EQTRKKQKPLPEEEEQENNKSFNEAPV---EIPS--------------------------PSETP 1958
|:..::::.:.:|||:|:.:...::.. ::.| |..:|
Zfish 1843 EEDAEEERQVEDEEEEEDEEQEQQSAAREDDVMSRVRTEGSRQWLTQEEVHCFRSALEGKPDGSP 1907
Human 1959 AKP----SEPESTLQPVLSLIPREKKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYT 2019
.:| ||| |..|.:: ..|||:..||||||:||||||||||||.||:|:|:||||||||||
Zfish 1908 ERPGPATSEP--TPNPSVT-SQREKRVARPPKKKFQKAGLYSDVYKTDDPRSQLLQLKKEKLEYT 1969
Human 2020 PGEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVD 2084
||||:|||.|||||| |||||||||||||||||||.|||:||||:||||||||||||||||
Zfish 1970 PGEHDYGLLPAPIHV-----GKYLRQKRIDFQLPYDILWLWKHDQLYKRPDVPLYKKIRSNVYVD 2029
Human 2085 VKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLER 2149
||||||||||||||:.|||.:.|||.||||||||:|||||:||||.:||.|||||:|||||||||
Zfish 2030 VKPLSGYEATTCNCRLPDDSSEKGCQDDCLNRMIYAECSPSTCPCSDQCDNQRIQKHEWVQCLER 2094
Human 2150 FRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFR--------------------------NRM 2188
||||.||||||||:||:||||||||||||||||||| :||
Zfish 2095 FRAEGKGWGIRTKQPLRAGQFIIEYLGEVVSEQEFRKYIASDCRLHQVKIPMLGENKKQIGVSRM 2159
Human 2189 IEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAG 2253
:|||.:||.|||||||||||||||||||||||:||||:||||||||||||||||||:||||:.:|
Zfish 2160 MEQYFSHSGHYCLNLDSGMVIDSYRMGNEARFVNHSCEPNCEMQKWSVNGVYRIGLFALKDINSG 2224
Human 2254 TELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKS 2318
|||||||||||||.|:||:||||.|.|||||||||:|:||| .:|.:......::.||.||||||
Zfish 2225 TELTYDYNFHSFNTEEQQVCKCGSEGCRGIIGGKSKRINGL-PAKGAGSGGGARRLGRLKEKRKS 2288
Human 2319 KHKLKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKH 2383
||.|||| .||.|:: ::....|.|||||||||||||||.|||:|||||:|:|||.:|.
Zfish 2289 KHSLKKR----EEESSDS----SKFYQHLLMKPMSNRERNFVLKHRVFLLRNWEKMREKQELLKR 2345
Human 2384 TSDNIH---SASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARL 2445
..:... ..||||||.|:.|||||||||||:||||||||:||||||||||||||.||.|.|||
Zfish 2346 EGERERENSGLSLYTRWGGVIRDDGNIKSDVFLTQFSALQTSRSVRTRRLAAAEENTEVTRTARL 2410
Human 2446 AQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEA 2510
|.|||||||.|.||||||.|.|||||||||.:|:|..||||::|||||.||:||||:|:|||.||
Zfish 2411 AHIFKEICDMITSYKDSSGQPLAAPLLNLPSRKRNTQYYEKVTDPLDLSTIDKQILSGHYKTDEA 2475
Human 2511 FDADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEK 2575
||||||||||||||||||||.|||||||||||||.|||||:.||||||||||||||||:: .|:
Zfish 2476 FDADMLKVFRNAEKYYGRKSAVGRDVCRLRKAYYGARHEAAVQIDEIVGETASEADSSDS--LER 2538
Human 2576 EN----------GHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDP 2630
:: .|:|||||||||||:||||||||||:|||||||||||.:.:||||||||||||
Zfish 2539 DHAHHHHHDGGGSHDKDDDVIRCICGMYKDEGLMIQCEKCMVWQHCDCMRLEADVEHYLCEQCDP 2603
Human 2631 RPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHIN 2695
|||||||||:|:|.|||.|.:|:||||||||||.||||||||||||||.:|.|||||||||||||
Zfish 2604 RPVDREVPMVPQPSYAQSGFIYYICLLRDDLLLHQGDCVYLMRDSRRTTEGQPVRQSYRLLSHIN 2668
Human 2696 RDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCC 2760
|||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
Zfish 2669 RDKLDIFRIEKLWKNEKGERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCC 2733
Human 2761 VLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFS 2825
|||||||||||||||||||||||||||||||||||||||||||||||||||:||||:||||:|||
Zfish 2734 VLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFNHFPKRLTPKRDFS 2798
Human 2826 PHYVPDNYKRNGGRSSWKSERSKP-----------------PLKDLGQEDDALPLIEEVLASQEQ 2873
|||||||||||||||:|||||.|. |.: |.||.......:..|:||.
Zfish 2799 PHYVPDNYKRNGGRSAWKSERPKDEEPSSSSTSCERLSSSFPRE--GDEDGGRGAEGDAEAAQEG 2861
Human 2874 AANEIPSLEEPEREGATANVSEGEKKTEE---------------------SSQEP-QSTCTPE-- 2914
::...|....| .|..||. .|.|.:.|| .:||| .:.|:..
Zfish 2862 SSTPRPQRSSP-LESRTAG-EEDEAEEEEDRERRREMQEEEEEEGCREKAGAQEPIDAQCSSSIS 2924
Human 2915 ---------ERRHNQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRRTLFIPENSFRK 2969
.||..||||||:|||:||.:.|.||||||||||||||||:||||||.:.|...||
Zfish 2925 SSPLHPAILGRREAQRERLNKILLDLLHRAPTKNAIDVTYLLEEGSGRRLRRRTLGLSEFICRK 2988
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