DRSC/TRiP Functional Genomics Resources

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Protein Alignment ASH1L and ash1

DIOPT Version :9

Sequence 1:NP_001353106.1 Gene:ASH1L / 55870 HGNCID:19088 Length:2969 Species:Homo sapiens
Sequence 2:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster


Alignment Length:2555 Identity:685/2555 - (26%)
Similarity:1060/2555 - (41%) Gaps:682/2555 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   732 KGLELERSEL--FKNVSCSSLSNSNSEPAKFMKNIGPPSF--VDHDFLKRRLPKLSKSTAPSLAL 792
            |.||.:|::.  .:|....|:::.:|: :|.:|:....|.  .|.|.|:.|:    .:..|:|.:
  Fly    12 KVLETQRAQESGSENEETDSITDQSSQ-SKSIKSATQFSVQRSDTDGLRMRI----SAIRPTLGV 71

Human   793 LADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPKRGRPKSKEMPQLEGPPK--RTLKIPASKVF 855
            :|..:.|..:..:|....|....:.:....    |:.:.|.|::....|..|  :..|...|::.
  Fly    72 VATKKPPKSRKMSTQDTESGCSEAKNRAVS----KKVKVKRKKLASSSGISKSDKVSKSKKSQIS 132

Human   856 SLQSKEEQEPPILQPEIEIPSFKQGLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPS 920
            :..|..|.:.|:                         ...|.|:     |.||..|...|.:|.|
  Fly   133 AFSSDSEDDLPL-------------------------KVHQQRA-----PRVLLSAIIQAAQSAS 167

Human   921 KLESESDNHRSSSDFFESEDQLQDPDDLDDSHRPSVCSMSDLEMEPDKKITKRNNGQLMKTIIRK 985
            |  ...|...|||                |:..|::...:...:|.|.:.|      .::...||
  Fly   168 K--PTLDIGISSS----------------DNELPNLVQAAIKRVESDTEDT------TVEGSFRK 208

Human   986 INKMKTLKRKKLLNQILSSSVESSNKGKVQSKLHNTVSSLAATFGSKLGQQ-INVSKKGTI---- 1045
            ..|.|.|.:.:  :.:|...:|.:             ..|..|..:||.:: :..:|:.|:    
  Fly   209 AAKDKNLPQYQ--STLLQDFMEKT-------------QMLGQTVNAKLAEEKVAKAKEETLVQTA 258

Human  1046 YIGKRRGRKPKTVLNGILSGSPTSLAVLEQTAQQAAGSALGQILPPLLPSSASSSEILPSPICSQ 1110
            ...||||| ||.|:..:.:...:..|:     .::|.|.       ::.:::::....|||....
  Fly   259 VPRKRRGR-PKKVVPTVPAPGNSGPAI-----NESADSG-------VISTTSTTQSTTPSPKMQN 310

Human  1111 SSGTSGGQSPVSSDAGFVEPSSVPYL---HLHSRQGSMIQTLAMKKASKGRRRLSPPTLLPNSPS 1172
            .:....|..|::|       ||.|.:   :|..|..:..:.|.....|| ||:.:..|..  |.|
  Fly   311 ENAVPTGSLPIAS-------SSKPKIDMAYLDKRMYATERVLYPPPRSK-RRQNNKKTAC--SSS 365

Human  1173 HLSEL-------------------TSLKEATPSPISESHSDETIPSDSGIGTDNNSTSDRAEKFC 1218
            :..||                   .|:..|:.:..|.:...:.:.:.||..:|..|.        
  Fly   366 NKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSV-------- 422

Human  1219 GQKKRRHSFEHVSLIPPETSTVLSSLKEKHKHKCKRRNHDYLSYDKMKRQKR------------- 1270
              :.:|.|..|.|....:.|             ||.|   |.:...|.|:.|             
  Fly   423 --RHQRSSHNHNSGYKSDAS-------------CKSR---YSTKSCMSRRSRAKSCGYRSDCKES 469

Human  1271 -------KRKKKYPQLRNRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFY 1328
                   :||::...|......|.:.:.:  |.:|:.:.:...|.                    
  Fly   470 GKSGLRMRRKRRASMLLKSSADDTVEDQD--ILQLAGLSLGQSSE-------------------- 512

Human  1329 THPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTA 1393
                   :...||.||.||                    ||                    |.|:
  Fly   513 -------ESNEYISKPSLK--------------------SL--------------------PTTS 530

Human  1394 APIGLGYYGRYPPT--LYPPPPSPSFTTP-------------LPPPSYMHAGHLLLNPAKYHKKK 1443
            |....|...||..|  .:....|.|.|.|             .|.||                  
  Fly   531 ASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPS------------------ 577

Human  1444 HKLLRQEAFLTTSRTPLLSM-STYPSVPPEMAYGWMVEHKHRHRHKHREHRSSEQ------PQVS 1501
                :....:.:.|:...|| |:|.|....|        :.|||.|...|..|..      .::.
  Fly   578 ----KSSCKIKSRRSSAASMCSSYVSGVSRM--------RRRHRRKSFSHNKSLNIDSKLLTEIE 630

Human  1502 MDTGSSRSVLESLKRYRFGKDAV-GERYKHK-----EKHRCHMSCPHLSPSKSL-INREEQWVHR 1559
            :.|.:..|      |.|...|.: |...|.|     .|.:..::.|  ||::.| :|      ..
  Fly   631 IITSTFNS------RCRIQDDRLTGSSGKEKLLADANKLQATLAAP--SPAQQLTLN------GG 681

Human  1560 EPSE--SSPLALGLQ-----TPLQIDCSESSPSLSLGGFTPNSEPASSDEHTNLFTSAIGSCRVS 1617
            .|:.  |.||..||:     .|| :|.:..|.|.|   .|||..               ||   |
  Fly   682 GPASTLSKPLKRGLKKRKLSEPL-VDFAMLSASAS---GTPNGS---------------GS---S 724

Human  1618 NPNSSGRKKLTDSPGLFSAQDTSLNRLHRKESLPSNER----------------------AVQTL 1660
            |.|:..|.|.:.|....|..|..|....|...|...||                      |.::.
  Fly   725 NGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKST 789

Human  1661 AGS------------------------QPTS-----DKPSQRP------------------SEST 1678
            |.:                        ||||     ...|..|                  |.|:
  Fly   790 ASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSS 854

Human  1679 NCSPTRKR---SSSESTSSTVNGVPSRSPRLVASGDDSVDSLLQRMVQNEDQEPMEKSIDAVIAT 1740
            .||..::|   ::.:..|:..:.|..:||    :|......:.:..|:.|.|.|:.|..::||..
  Fly   855 LCSLKQQRRGGAAKQKVSAAKDLVQLQSP----AGSYPPPGVFEPSVELEIQIPLSKLNESVITK 915

Human  1741 ASAPPSSSPGRS--HSKDRTLGKPDSLLVPAVTSDSCNNSISLLSEKLTSSCSPHHIKRSVVEAM 1803
            |..   .||..|  ..|:.|..:....:|..:...:..|  .||..|...      |.|:....:
  Fly   916 AEV---ESPLLSALDIKEDTKKEVGQRVVETLLHKTGGN--LLLKRKRKK------INRTGFPTV 969

Human  1804 QRQARKMCNYDKILAT----KKNLDHVNKILKAKKLQRQARTGNNF-VKRRPGRP---------- 1853
            :|:.||:....:..|.    :...|..::.|::   .|:.|:.||. |:..|..|          
  Fly   970 RRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQS---LRETRSSNNVNVQAAPNPPLDCERVPQAG 1031

Human  1854 -----------RKCPLQAVVSMQAFQAAQFV--------NPELNRDEEGAALHLSPDTVTDVIEA 1899
                       :|.|..:||:::..|..|..        .|: ||::..||....|.:..::   
  Fly  1032 EARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPK-NREQAEAAPQPPPKSEPEI--- 1092

Human  1900 VVQSVNLNPEHKKGLKRKGWLLEE--------QTRKKQKP---LPEEEEQENNKSF--------- 1944
                   .|..|:|.:.|..:|||        |.:.|.:|   ||:..:...|.|.         
  Fly  1093 -------RPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKN 1150

Human  1945 --------NEAPVEIPS----PSETPAKPSEPESTLQPV-LSLIPREKKP--------PRPP--- 1985
                    .|.||:..:    |.|.|....|.::..:.. |..||.|..|        |.|.   
  Fly  1151 LEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYA 1215

Human  1986 ---------------------KKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPG-EHEYG-- 2026
                                 ||.|..|||:|:.||.:      :.....|:...|| |.:.|  
  Fly  1216 SCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQS------LMPPPAKVNKKPGLEEQVGPA 1274

Human  2027 -LFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPL--YKKIRSNVYVD-VKP 2087
             |.|.|.:     ..||||:..:||:|||||.|.:.:::|..:..||.  |:|||:|||.: |:|
  Fly  1275 SLLPPPPY-----CEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRP 1334

Human  2088 -LSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFR 2151
             |:|::..|||||...:   |.|:|:|||||::.||||:.||.||:|.||:||||.....:|||.
  Fly  1335 NLAGFDHPTCNCKNQGE---KSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFM 1396

Human  2152 AEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGN 2216
            ..:||||:|||.|:..|.:|:||:||||:|:||:.||...|.|.:.||||:||.|:|||..|||:
  Fly  1397 TADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGS 1461

Human  2217 EARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCR 2281
            :.||:||||:||||||||||||:.|:.|:|.:.:..|.||||||||..||..:.|.|:|...:||
  Fly  1462 DCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526

Human  2282 GIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQ 2346
            |:||||||||..|       |....|.||.....|..:.:.:|.:.|...:..::|::...:.  
  Fly  1527 GVIGGKSQRVKPL-------PAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVA-- 1582

Human  2347 LQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSAS---LYTRWNGIC--RDDGN 2406
             :::|:|.:|:..|.:.:.|||||:||||:.  :.|..||...:||   |.|. ||..  |....
  Fly  1583 -KLQPLSEKEKKLVRQFNTFLVRNFEKIRRC--KAKRASDAAATASSPALGTT-NGDIPGRRPST 1643

Human  2407 IKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPL 2471
            ..|.....|.|||.:.|:::||.|..|..:.|:.:.|::|.:.::||..:.:.|.|.       |
  Fly  1644 PSSPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSD-------L 1701

Human  2472 LNLPPKKKNADYYEKISDPL---------DLITIEKQILTGYYKTVEAFDADMLKVFRNAEKYYG 2527
            |.....||.......:|..|         :..:|:.|:..|:|||.:.||..|.::|..|::.:|
  Fly  1702 LTTVSSKKKKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHG 1766

Human  2528 RKSPVGRDVCRLRKAYYNARHEASAQIDEIVGET------------ASEADSSETSVSEKENGHE 2580
            ......:.:..|:.:|...:..:..|:.||:|::            :||.:..:.:|.:.....|
  Fly  1767 DDEGKEKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKE 1831

Human  2581 K---------------------DDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYL 2624
            :                     |:|||||||||||||||||||.|||||||.:|...:.|.::|.
  Fly  1832 RDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQ 1896

Human  2625 CEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPV----R 2685
            ||:|:||.||||:|:   ..:.:.|..|::.|:|.||.:||||.||::||.....:...|    :
  Fly  1897 CERCEPREVDREIPL---EEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTKK 1958

Human  2686 QSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEII 2750
            .:|..:..|:..:.||||:|.|||||..:||.||||:.|||||.|.||||||.||:.||.|||::
  Fly  1959 HTYETIGAIDYQECDIFRVEHLWKNELGKRFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVV 2023

Human  2751 PLEAVVGTCCVLDLYTYCKGRPKGVKEQD-VYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHF 2814
            |:|.|:|.|.|||..|:|||||....::| .|||:.|:||:|..|.|...| :|.|||.|||..|
  Fly  2024 PIELVIGRCWVLDRTTFCKGRPMECNDEDHCYICELRVDKTARFFSKAKAN-HPACTKSYAFRKF 2087

Human  2815 PKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIP 2879
            |:|:...|.::||.|..        |..|:.:.|..| |:|.....:   .:|...|||...::.
  Fly  2088 PEKIKISKSYAPHDVDP--------SLLKTRKQKTEL-DVGAGPTTM---HKVSGRQEQHQAKMV 2140

Human  2880 SLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRE-RLNQILLNL-LEKIPGKNA-- 2940
            . .:|....|.|:.:.....|         ...|.::...:|: ||..:|:.: |:.:..:.|  
  Fly  2141 G-RKPRGISAPADATAVHVVT---------PVAPNKQMLKKRKSRLENVLITMKLKCLDAQTAQE 2195

Human  2941 --IDVTYLLEEGSGRKLRRR 2958
              ||::|||   |||..|:|
  Fly  2196 QPIDLSYLL---SGRGARQR 2212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASH1LNP_001353106.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..525
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..583
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..845 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..966 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1231 19/98 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1281 10/57 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1489..1508 3/24 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1711 38/202 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1741..1761 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1911..1991 30/144 (21%)
Catalytic domain 2069..2288 121/222 (55%)
AWS 2092..2143 CDD:197795 28/50 (56%)
SET 2146..2266 CDD:214614 69/119 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2346 13/57 (23%)
Bromo_ASH1 2443..2548 CDD:99955 26/113 (23%)
PHD_ASH1L 2586..2628 CDD:277023 29/41 (71%)
BAH_polybromo 2665..2799 CDD:240068 69/138 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2825..2856 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2876..2919 5/42 (12%)
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 28/50 (56%)
SET 1392..1512 CDD:214614 70/119 (59%)
Bromo_ASH1 1680..1787 CDD:99955 26/113 (23%)
PHD_ASH1L 1858..1900 CDD:277023 29/41 (71%)
BAH_polybromo 1929..2073 CDD:240068 72/143 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157989
Domainoid 1 1.000 149 1.000 Domainoid score I4444
eggNOG 1 0.900 - - E2759_KOG1083
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.721928 Normalized mean entropy S5577
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 1 1.000 - - FOG0007422
OrthoInspector 1 1.000 - - oto91436
orthoMCL 1 0.900 - - OOG6_106446
Panther 1 1.100 - - LDO PTHR46147
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X5557
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.690

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